Papillary Lesions of the Male Breast

Zhong, Elaine; Cheng, Esther; Goldfischer, Michael; Hoda, Syed A.

doi:10.1097/pas.0000000000001340

Cited by 16 publications

(5 citation statements)

References 54 publications

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“…Papillary in situ and invasive carcinomas are not uncommon in the male breast, unlike the female breast. Zhong [48] finds in a review that papillary lesions of the male breast papillary carcinomas span a wide clinicopathological spectrum, and both invasive and noninvasive papillary carcinomas have a favorable prognosis, as it is also reported by Avau [49].…”

Section: Pathologymentioning

confidence: 59%

An Update on the General Features of Breast Cancer in Male Patients- a Literature Review

Ionescu¹,

Nicolescu²,

Marincaş³

et al. 2022

Preprint

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Male breast cancers are uncommon, as men account for less than 1 percent of all breast carcinomas. Among the predisposing risk factors for male breast cancer, the following appear to be significant: a) breast/chest radiation exposure, b) estrogen use, diseases associated with hyper-estrogenism, such as cirrhosis or Klinefelter syndrome, and c) family health history. Furthermore, there are clear familial tendencies, with a higher incidence among men who have a large number of female relatives with breast cancer and d) major inheritance susceptibility. Moreover, in families with BRCA mutations, there is an increased risk of male breast cancer, although the risk appears to be greater with inherited BRCA2 mutations than with inherited BRCA1 mutations. Due to diagnostic delays, male breast cancer is more likely to present at an advanced stage. A core biopsy or a fine needle aspiration must be performed to confirm suspicious findings. Infiltrating ductal cancer is the most prevalent form of male breast cancer, while invasive lobular carcinoma is extremely uncommon. Male breast cancer is almost always positive for hormone receptors. A worse prognosis is associated with a more advanced stage at diagnosis for men with breast cancer. And randomized controlled trials which recruit both female and male patients should be developed in order to gain more consistent data on the optimal clinical approach.

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Section: Pathologymentioning

confidence: 59%

An Update on the General Features of Breast Cancer in Male Patients- a Literature Review

Ionescu¹,

Nicolescu²,

Marincaş³

et al. 2022

Preprint

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“…Solid-papillary carcinom is more commonly found in post-menopausal women, however cases have been reported in men. [10][11][12] Dysplastic cells originate from the ductal epithelium with 50% of cases presenting as retroareolar or subareolar masses with bloody nipple discharge. 90% of lesions present as localized tumors with 8% presenting with locoregional disease and 0.4% distant metastasis.…”

Section: Discussionmentioning

confidence: 99%

Axillary chest wall solid-papillary carcinoma: A case report on presentation and management

Niver

Strom

2023

Rare Tumors

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Papillary breast carcinomas comprise <1% of all breast cancers. They are notorious among surgical pathologists for posing diagnostic difficulty, especially with small sample sizes, such as a core-needle biopsy and carry potential for overtreatment. Solid-papillary carcinoma is a subtype of papillary breast carcinomas that affects elderly females and generally has a favorable diagnosis in its in-situ form. This report focuses on the unique and clinically aggressive presentation and treatment of invasive solid-papillary carcinoma that was discovered along the axillary chest wall after an ipsilateral mastectomy for multifocal ductal carcinoma in situ.

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“…However, there are no specific clinical and imaging features that can distinguish EPC from other papillary lesions. 5 Fine-needle aspiration cytology and core biopsy are usually performed before performing surgery. However, the false negative results with fine-needle aspiration or biopsy are relatively frequent.…”

Section: Discussionmentioning

confidence: 99%

“…Papillary ductal carcinoma in situ is the most common subtype (75%). 4,5 Encapsulated papillary carcinoma (EPC) only accounts for a small proportion of papillary carcinomas (12%). EPC is characterized morphologically by fine fibrovascular cores covered by neoplastic epithelial cells of low or intermediate nuclear grade and surrounded by a fibrous capsule.…”

Section: Introductionmentioning

confidence: 99%

Cystic Encapsulated Papillary Carcinoma in the Male Breast: An Unusual Feature With a Diagnostic Challenge

Saluja

Mai

et al. 2021

Int J Surg Pathol

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Papillary carcinoma in the male breast is uncommon. Here, we report a case of a large encapsulated papillary carcinoma (EPC) in a 62-year-old male. The patient presented with a left breast mass of 1-year duration and bloody nipple discharge for several days. Mammography and breast ultrasonography showed a large left breast mass. The initial biopsy demonstrated fat necrosis with acute and chronic inflammation only. Due to clinical suspicion, a repeat biopsy was performed and revealed scant fragments of papillary carcinoma in a background of inflammation. The patient underwent left total mastectomy. Grossly, the breast contained a 9.0 cm entirely cystic lesion lined by a hemorrhagic thick fibrotic wall. No solid area was identified in the cyst. The entire cyst wall was examined under microscopy; only a few sections with papillary carcinoma were identified. The lesion was confined to the cyst wall; so, a diagnosis of EPC was made. Compared to the previously reported EPC cases of male breast, the lesion of this case was unusually cystic, which making the diagnosis challenging. Therefore, awareness of this unusual feature, repeat biopsy when the pathology result is discordant, and extensive sampling of the lesion are essential for making the correct diagnosis and guiding patient management.

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Papillary Lesions of the Male Breast

Cited by 16 publications

References 54 publications

An Update on the General Features of Breast Cancer in Male Patients- a Literature Review

An Update on the General Features of Breast Cancer in Male Patients- a Literature Review

Axillary chest wall solid-papillary carcinoma: A case report on presentation and management

Cystic Encapsulated Papillary Carcinoma in the Male Breast: An Unusual Feature With a Diagnostic Challenge

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