Papillary meningioma: A malignant variant of meningioma

Ludwin, Samuel K.; Rubinstein, Lucien J.; Russell, Dorothy S.

doi:10.1002/1097-0142(197510)36:4<1363::aid-cncr2820360427>3.0.co;2-z

Cited by 145 publications

(49 citation statements)

References 14 publications

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“…1,3,4,[6][7][8][9][11][12][13][14]16,19) The risk of CSF dissemination of this tumor is not clear. Twelve of these 18 patients had undergone two or more surgical procedures.…”

Section: Discussionmentioning

confidence: 99%

Malignant Intracranial Meningioma With Spinal Metastasis -Case Report-

Kuroda

Kashimura

Ogasawara

et al. 2009

Neurol. Med. Chir.(Tokyo)

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A 48-year-old woman presented with a left cerebellopontine angle mass. Over a 93-month period, the patient underwent seven surgeries, two radiosurgeries, and one external beam radiotherapy. The tumor was histologically benign at the first operation, but exhibited unusually aggressive behavior after failed radiosurgery and demonstrated clinical characteristics of malignancy such as spinal metastasis. The patient underwent gamma knife radiosurgery (GKR) for recurrence after the first operation, despite the tumor being located in a resectable region. The tumor did not respond. Six months after the sixth surgery, the patient presented with progressive lower extremity paraparesis and sensory disturbance below the T11 dermatome. Magnetic resonance imaging revealed multiple intradural mass lesions located at the T2, T11-T12, and L2 levels. She died 4 months after the diagnosis of spinal metastases. Retrospectively, we speculate that if a tumor is located in a resectable region and Simpson grade I or II tumor resection is possible, direct surgery may be a safer option than GKR.

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“…1,3,4,[6][7][8][9][11][12][13][14]16,19) The risk of CSF dissemination of this tumor is not clear. Twelve of these 18 patients had undergone two or more surgical procedures.…”

Section: Discussionmentioning

confidence: 99%

Malignant Intracranial Meningioma With Spinal Metastasis -Case Report-

Kuroda

Kashimura

Ogasawara

et al. 2009

Neurol. Med. Chir.(Tokyo)

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“…Regarding the clinical behavior of PM, the study by Ludwin et al (13) indicated that these tumors frequently display an aggressive clinical behavior, which is marked by a high rate of local recurrence and/or development of distant metastases. Jiang et al (16) reported a case of intraparenchymal PM of the brainstem.…”

Section: A B C Dmentioning

confidence: 92%

“…In addition, 25% of the tumors assessed occurred in patients within the first two decades of their life, with a slightly increased incidence in females (female to male ratio, 3:2). Furthermore, Ludwin et al (13) identified that a relatively large proportion of PM cases in their study (8/17 patients) occurred in children, while Pasquier et al (14) reported seven cases of PM that occurred in patients between the ages of 21 and 69 years.…”

Section: A B C Dmentioning

confidence: 99%

Papillary meningioma of the jugular foramen: A case report

Wang

et al. 2015

Oncology Letters

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Abstract. Papillary meningioma (PM) is a rare histological variant of intracranial meningioma, which displays an aggressive behavior and its management is difficult. The present study reported the case of a 21-year-old male patient, who presented with headaches and dizziness. Upon neurological examination, left hypoglossal nerve palsy and left cerebellar signs were observed. Computed tomography and magnetic resonance imaging scans of the brain revealed a high-density mass in the left jugular foramen area. Following an uneventful complete surgical resection of the tumor, a definitive diagnosis of Grade III PM was determined based on the histopathological findings, according to the World Health Organization classification. CT scanning one day after surgery confirmed that the tumor had been completely resected, and after four years of follow-up, no evidence of transformation or recurrence was observed.

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“…The single most important factor in the clinical outcome of meningiomas is probably the localisation and resectability of the tumour [18]. However, some histological findings have been associated with a higher risk of recurrences [15,16,21]: invasion of the underlying brain tissue, a high degree of cellularity and cytological features of malignancy, including aneuploidy, mitotic figures, large prominent nucleoli and the presence of necrotic areas [5,7,9,22].…”

Section: Introductionmentioning

confidence: 99%

Expression of β2 integrins and macrophage-associated antigens in meningeal tumours

Mosnier¹,

Perret

Scoazec

et al. 2000

Virchows Archiv

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This study assessed the expression of leukocyte integrins and macrophage-associated antigens in meningiomas. Fourteen benign meningiomas, ten atypical/anaplastic meningiomas, two hemangiopericytomas and one solitary fibrous tumour (SFT) were included. Frozen sections were immunostained using antibodies directed against leukocyte integrins, CD68, CD14, CD2, CD1a, DRC1 and CD34. Their expression was evaluated semi-quantitatively. Ki67 positive cells were counted. Arachnoid membranes served as controls. Arachnoid cells expressed the beta2-integrin subunit and KP1. Beta2 was detected in the tumour cells of 14 meningiomas. In nine cases, this was associated with an alpha-integrin subunit. There was no statistical difference in the expression of beta2 between benign and atypical/anaplastic meningiomas. KP1 was constantly expressed by the tumour cells of meningiomas. It was not expressed by other meningeal tumours. CD34 was detected in the fibrous meningiomas, hemangiopericytomas and the SFT. In each tumour, macrophages were more numerous than T lymphocytes. There was no statistical difference in the density of macrophages and T lymphocytes between the benign and atypical/anaplastic meningiomas. There was no correlation between the Ki67 proliferation index and macrophage infiltration. Meningiomas, through the expression of leukocyte antigens, have a very particular phenotype. The expression of beta2 integrins could play a role in the attraction of immunocompetent cells in the stroma of meningiomas.

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Papillary meningioma: A malignant variant of meningioma

Cited by 145 publications

References 14 publications

Malignant Intracranial Meningioma With Spinal Metastasis -Case Report-

Malignant Intracranial Meningioma With Spinal Metastasis -Case Report-

Papillary meningioma of the jugular foramen: A case report

Expression of β2 integrins and macrophage-associated antigens in meningeal tumours

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