Papillary Morphology in Adult Human Kidneys and in Baby and
Adult Pig Kidneys

Thomsen, Henrik S.; Larsen, Svend; Talner, Lee B.

doi:10.1159/000474075

Cited by 20 publications

(9 citation statements)

References 16 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In a recent retrospective study in humans, Thompson Although the porcine kidney is anatomically similar to the human kidney, it is very unlikely that this is the same in regards to renal function. 19 We believe that establishing the occurrence of ultrastructural cellular alterations because of different renal WIT may help to achieve a better understanding of this process and, possibly, more accurately compare the animal models to human beings. Additionally, long-term studies of renal function after temporary WI are lacking.…”

Section: Efficacy Of Two Renal Cooling Techniques 447mentioning

confidence: 99%

Cold Renal Ischemia: Comparison of Efficacy Between Two Techniques of Cooling, in a Swine Model

Guerra

Leonardi

Otsuka

et al. 2010

Journal of Endourology

View full text Add to dashboard Cite

Objectives: In a swine model of renal ischemia, we compared the effectiveness of the transureteral retrograde cold saline perfusion technique to the traditional method of renal cooling with ice slush, in achieving adequate parenchymal temperatures for functional preservation of the organ. Physiological and histological effects were also assessed. Methods: Twenty-four domestic male pigs were sampled into four groups to be submitted to a 60-minute ischemia of the left kidney without cooling, with either one of the two cooling techniques (cold saline retrograde perfusion or ice slush), or sham surgery. All of them had also a concomitant right nephrectomy. Renal cortical and medullary temperatures were recorded throughout the experiment. Urinary output was measured, and serum renal function tests were carried on, pre-and postoperatively. After 5 days, the animals were euthanized and their kidneys were submitted to histological analysis. Results: Mean renal temperature fell in both groups submitted to kidney cooling. With ice slush, a faster drop was observed and a lower minimum temperature was achieved (5.08C in the cortex and 6.38C in the medulla, vs. 25.48C and 24.98C with retrograde cooling). In the other groups, temperature was unchanged. Urinary output and serum creatinine worsened after the experiment, but without significant differences among groups. The histological analysis showed no differences among the four groups, for the studied ischemia time. Conclusions: Ice slush and retrograde perfusion of cold saline are both effective for cooling the kidney during ischemia. Ice slush is faster in doing so, and it allows much lower temperatures to be achieved in the renal parenchyma. With ischemia time of 60 minutes, no significant differences on the occurrence of functional and histological alterations were detected, even for the group without a cooling procedure.

show abstract

Section: Efficacy Of Two Renal Cooling Techniques 447mentioning

confidence: 99%

Cold Renal Ischemia: Comparison of Efficacy Between Two Techniques of Cooling, in a Swine Model

Guerra

Leonardi

Otsuka

et al. 2010

Journal of Endourology

View full text Add to dashboard Cite

show abstract

“…Porcine renal anatomy is similar to that of humans in that it is a multipyramidal system with an undivided cortex, with each medullary pyramid forming a separate papilla along with the formation of some compound papillae. 1,2 Porcine renal physiology is also similar to that of humans in regard to maximal urine concentration (porcine 1,080 vs human 1,160 mOsm/L), glomerular filtration rate (porcine 130 vs human 126-175 mL/min per 70 kg), and total renal blood flow (porcine 4.0 vs human 3.0-4.4 mL/min · g). 3 Thus, the anatomic and physiologic renal similarities between sows and humans make the porcine model a promising model for the study of urolithiasis.…”

Section: Introductionmentioning

confidence: 95%

Dietary Induction of Long-Term Hyperoxaluria in the Porcine Model

Patel

Penniston²,

Iwicki³

et al. 2012

Journal of Endourology

View full text Add to dashboard Cite

show abstract

“…Comparing porcine and human kidneys, anatomic similarities include an undivided renal cortex, multiple medullary pyramids that each form a separate papilla or occasionally a complex papilla, especially in the upper pole [96]. Pigs in general have 8e12 papillae compared to humans which usually have 4e18 [97].…”

Section: Anatomic/physiologic Comparison Between Pigs and Humansmentioning

confidence: 99%

Animal models of urinary stone disease

Tzou

Taguchi

Chi

et al. 2016

International Journal of Surgery

View full text Add to dashboard Cite

h i g h l i g h t sMultiple methods induce animal hyperoxaluria and calcium oxalate crystal formation. Knockout mice models have been shown to produce hypercalciuria and cystinuria. Drosophila melanogaster represents a powerful genetic model for stone disease. a r t i c l e i n f o a b s t r a c tThe etiology of stone disease remains unknown despite the major technological advances in the treatment of urinary calculi. Clinically, urologists have relied on 24-h urine collections for the last 30e40 years to help direct medical therapy in hopes of reducing stone recurrence; yet little progress has been made in preventing stone disease. As such, there is an urgent need to develop reliable animal models to study the pathogenesis of stone formation and to assess novel interventions. A variety of vertebrate and invertebrate models have been used to help understand stone pathogenesis. Genetic knockout and exogenous induction models are described. Surrogates for an endpoint of stone formation have been urinary crystals on histologic examination and/or urinalyses. Other models are able to actually develop true stones. It is through these animal models that real breakthroughs in the management of urinary stone disease will become a reality.

show abstract

Papillary Morphology in Adult Human Kidneys and in Baby and Adult Pig Kidneys

Cited by 20 publications

References 16 publications

Cold Renal Ischemia: Comparison of Efficacy Between Two Techniques of Cooling, in a Swine Model

Cold Renal Ischemia: Comparison of Efficacy Between Two Techniques of Cooling, in a Swine Model

Dietary Induction of Long-Term Hyperoxaluria in the Porcine Model

Animal models of urinary stone disease

Contact Info

Product

Resources

About