Papillary squamous cell carcinoma of the oral mucosa: immunohistochemical comparison with other carcinomas of oral mucosal origin.

Takeda, Yasunori; Satoh, Masanobu; Nakamura, Shinichi; Yamamoto, Hirotsugu

doi:10.2334/josnusd.43.165

Cited by 16 publications

(11 citation statements)

References 10 publications

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“…Other sites of involvement include the oral cavity, oropharynx, sinonasal tract, and nasopharynx [3,4]. In the oral cavity cases have been reported on the alveolar ridge, oral mucosa, floor of the mouth, ventral tongue, and rarely other areas [5][6][7][8]. Within head and neck PSCCA, a relationship has been established with the human papillomavirus (HPV) to varying degrees [4,9].…”

Section: Introductionmentioning

confidence: 99%

Papillary Variant of Squamous Cell Carcinoma Arising on the Gingiva: 61 Cases Reported from Within a Larger Series of Gingival Squamous Cell Carcinoma

Fitzpatrick

Neuman

Cohen

et al. 2013

Head and Neck Pathol

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Papillary squamous cell carcinoma (PSCCA) is a rarely occurring variant of squamous cell carcinoma (SCCA) with distinctive exophytic and papillary features and a more favorable prognosis than conventional SCCA. The larynx is the most commonly affected site in the head and neck. The oral cavity, oropharynx, sinonasal tract, and nasopharynx are also affected. Within the oral cavity cases have been reported on the alveolar ridge, oral mucosa, floor of the mouth, ventral tongue, and rarely other areas. We identified 61 cases of gingival PSCCA within the parameters of a larger study of 519 cases of gingival SCCA. We evaluated the clinical and histologic features of these lesions. The average age of the PSCCA patient was 74 years, with a very slight male predominance of 1.2:1. The mandible was affected nearly twice as often (64 %, n = 39) as the maxilla (35 %, n = 21, and 1 % of cases unspecified), and the most common location by far was the mandibular posterior region (52 %, n = 32). Most lesions were reportedly present over 2 months in duration (48 %, n = 29) prior to biopsy but a significant amount of clinicians were unsure of the duration of the lesion as well (36 %, n = 22). Only 10 cases (16 %) were reportedly present less than 2 months. The most common clinical presentation was that of an erythematous or mixed white and red exophytic mass (74 %, n = 45). 62 % (n = 38) of submitting clinicians considered a malignant or premalignant lesion in their differential diagnosis, but other clinical impressions included papillomas, reactive gingival lesions, and fungal infections. Histologically, 88 % (n = 52 of 59 cases graded) of the lesions were either well or moderately-well differentiated. PSCCA is a rare subtype of SCCA which has been reported infrequently involving the gingiva or alveolar ridges but should be considered by clinicians for the differential diagnosis of papillary gingival masses.

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Section: Introductionmentioning

confidence: 99%

Papillary Variant of Squamous Cell Carcinoma Arising on the Gingiva: 61 Cases Reported from Within a Larger Series of Gingival Squamous Cell Carcinoma

Fitzpatrick

Neuman

Cohen

et al. 2013

Head and Neck Pathol

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“…3,8 In the rest of the cases, the majority of patients presented phonation problems, including hoarseness, 7,13 followed by mass or exophytic proliferation. 5,15 Other symptoms included progressive dyspnea, 14 hemoptysis, 7,14 cough, 7,13 lump in the neck, 17 and sensation of a strange body (in our case).…”

Section: Clinical Manifestationsmentioning

confidence: 59%

“…3,7,8 The most common site involved was the larynx (3 cases in Cardesa et al, 5 17 cases in Suarez et al, 8 1 case in Ereño et al, 13 and 1 case in Shanon et al 14 ), followed by the alveolar ridge (20 cases in Ishiyama et al 3 ). The other sites affected were buccal mucosa (13 cases in Ishiyama et al 3 and 2 cases in Takeda et al 15 ), sinonasal tract (11 cases in Suarez et al 8 and 1 case in Judd et al 16 ), nasopharynx, 5 and oropharynx. 5,10,17…”

Section: General Characteristicsmentioning

confidence: 98%

Review Article: Relationship of Human Papillomavirus With Papillary Squamous Cell Carcinoma of the Upper Aerodigestive Tract: A Review

2008

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The purpose of this review is to evaluate case reports of papillary squamous cell carcinoma (PSCC) of the upper aerodigestive tract (UADT) to assess its relationship with human papillomavirus (HPV). The medical literature was searched for case reports of this condition. A total of 115 cases of PSCC were found that described the condition in sufficient detail. HPV detection was performed in only 22 of the 115 cases of PSCC (19%), and 11 of the 22 cases (50%) are related to this virus. The majority of cases related to HPV are produced by low-risk HPV type 6 followed by high-risk HPV type 16. Today, the association of HPV with PSCCs seems unclear because in the majority of patients tests were not performed for the detection of the HPV. This association should be clearly established to make a correct diagnosis and propose the best therapeutic strategies, such as new vaccines.

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“…15,16 These studies concentrated on determining whether these neoplasms contained the DNA of human papillomaviruses such as HPV-11 or HPV-6. This was found not to be true for PSCC lesions except in one case reported by Judd et al 15 In a study by Takeda et al, 17 PSCC was found to share the same prevalence for the immunohistochemic marker Ki-67 as other SCC lesions.…”

Section: Verrucous Carcinomamentioning

confidence: 87%

Papillary Squamous Cell Carcinoma Presenting on the Gingiva

Khan

Gossweiler

Zunt

et al. 2005

Journal of Periodontology

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Papillary squamous cell carcinoma of the oral mucosa: immunohistochemical comparison with other carcinomas of oral mucosal origin.

Cited by 16 publications

References 10 publications

Papillary Variant of Squamous Cell Carcinoma Arising on the Gingiva: 61 Cases Reported from Within a Larger Series of Gingival Squamous Cell Carcinoma

Papillary Variant of Squamous Cell Carcinoma Arising on the Gingiva: 61 Cases Reported from Within a Larger Series of Gingival Squamous Cell Carcinoma

Review Article: Relationship of Human Papillomavirus With Papillary Squamous Cell Carcinoma of the Upper Aerodigestive Tract: A Review

Papillary Squamous Cell Carcinoma Presenting on the Gingiva

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