Papillary Thyroid Carcinoma

Noguchi, Shiro; Murakami, Nobuo; Yamashita, Hiroto; Toda, Masakatsu; Kawamoto, Hitoshi

doi:10.1001/archsurg.133.3.276

Cited by 191 publications

(57 citation statements)

References 42 publications

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“…While the number of lymph nodes removed at neck dissection is not related to the recurrence rate of PTC [28], LCLNM affects the prognosis in proportion to the primary tumor size [29]. Lateral neck extension is thought to be associated with high rates of recurrence and distant metastasis in MPTC [11, 30, 31]. Radioactive iodine therapy has a limited role in eradicating evident metastasis, where surgical resection is necessary [31].…”

Section: Discussionmentioning

confidence: 99%

“…Lateral neck extension is thought to be associated with high rates of recurrence and distant metastasis in MPTC [11, 30, 31]. Radioactive iodine therapy has a limited role in eradicating evident metastasis, where surgical resection is necessary [31]. Therefore, the detection and management of LCLNM is necessary to improve the treatment outcome in MPTC.…”

Section: Discussionmentioning

confidence: 99%

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Ultrasonographic findings relating to lymph node metastasis in single micropapillary thyroid cancer

et al. 2014

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BackgroundIn thyroid cancer, preoperative ultrasonography (US) is performed to detect the primary tumor and lymph node metastasis (LNM), which are related to prognosis. This study examined the relationships between specific US findings and LNM in micropapillary thyroid cancer (MPTC).MethodsData on 220 patients with solitary MPTC who underwent total thyroidectomy and neck dissection between 2008 and 2009 were evaluated retrospectively. We classified the US findings according to the nature, shape, echogenicity, extent, margin, and calcification of the primary tumor and evaluated the correlations between these findings and those of LNM.ResultsHypoechogenicity (odds ratio = 2.331, P = 0.025) and marked hypoechogenicity (OR = 4.032, P = 0.016) of MPTC were risk factors for central LNM. All of the patients with lateral cervical LNM showed hypoechogenicity or marked hypoechogenicity. Hypoechogenicity (odds ratio = 5.349, P = 0.047) and other types of calcification (odds ratio = 2.495, P = 0.010) were significant risk factors for lateral cervical LNM.ConclusionsSpecific sonographic findings (hypoechogenicity or marked hypoechogenicity, and calcification) suggest LNM.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Ultrasonographic findings relating to lymph node metastasis in single micropapillary thyroid cancer

et al. 2014

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“…Although it remains unclear whether lymph node metastasis is associated with mortality, the risk of lymph node recurrence is thought to be increased when cervical lymph node metastasis is found at the time of diagnosis [1,9-11,13-15]. Re-operation for disease recurrence in the neck contributes to increased operative morbidity and medical costs [16-18].…”

Section: Discussionmentioning

confidence: 99%

“…To reduce the risk of recurrence, various types of lateral neck dissection (LND) have been introduced in patients with clinically positive nodes [1,9,10]. Although many surgeons in other countries do not perform prophylactic LND, this method is preferred by Japanese surgeons [11]. Less invasive neck dissection in PTC patients may avoid perioperative morbidity and improve patient quality of life.…”

Section: Introductionmentioning

confidence: 99%

Solitary lateral neck node metastasis in papillary thyroid carcinoma

et al. 2014

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BackgroundPapillary thyroid carcinoma (PTC) is associated with a high incidence of regional node metastasis, but the patterns of lateral neck node metastasis (LNM) vary. Occasionally, a solitary LNM (SLNM) is seen in PTC patients. We therefore assessed whether selective single level node dissection is appropriate in PTC patients with SLNM.MethodsWe retrospectively reviewed the medical records of 241 PTC patients who underwent total thyroidectomy with central neck dissection plus ipsilateral internal jugular node dissection (level II to IV) between January 2010 and December 2011. Of these patients, 51 had SLNM and 190 had multiple LNM (MLNM). The clinicopathologic characteristics of the two groups were compared.ResultsAge, gender ratio, and numbers of lateral neck nodes harvested (29.4 ± 11.0 versus 30.3 ± 9.5; P = 0.574) were similar in the SLNM and MLNM groups. Mean primary tumor size was significantly smaller in the SLNM than in the MNLM group (1.03 cm versus 1.35 cm; P = 0.037). The proportion of patients with primary tumor ≤ 1 cm was significantly greater in the SLNM group (60.8% versus 38.4%; P = 0.006), whereas the proportion with maximal node size ≤ 0.7 cm (28.9% versus 73.3%; P <0.001) and the proportion with capsular invasion (62.7% versus 83.7%, P = 0.002) were significantly lower in the SLNM than in the MLNM group.ConclusionsSelective single level neck dissection can be considered as an alternative to systemic lateral neck dissection in PTC patients with SLNM, maximal metastatic node size ≤ 0.7 cm, and no extrathyroidal invasion.

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“…In Japan, cervical lymph node dissection on the affected side is the standard procedure [15]. It has been reported that a local recurrence may be reduced by this procedure [16].…”

Section: Treatment Modalities For Large Papillary Carcinomas Of the Tmentioning

confidence: 99%

Nationwide Survey on the Treatment Policy for Well-differentiated Thyroid Cancer - Results of a Questionnaire Distributed at the 37th Meeting of The Japanese Society of Thyroid Surgery -

et al. 2005

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Abstract. The treatment policy for patients with well-differentiated thyroid cancer varies among institutions. Although surgery has been the mainstay of treatment for this cancer, there is no consensus concerning the optimal extent of thyroid resection or the extent of lymph node dissection. Furthermore, controversy remains with regard to the indications for radiation therapy and hormonal therapy in surgical or non-surgical cases and the treatment modalities for cancer recurrence. To determine the actual status of treatment policies for thyroid cancer in Japan, a questionnaire was distributed to all physicians who participated in the 37th meeting of the Japanese Society of Thyroid Surgery, to inquire into treatment options for well-differentiated thyroid cancer in relation to clinical stages in actual situations. The replies to this questionnaire were analyzed in this study.

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Papillary Thyroid Carcinoma

Cited by 191 publications

References 42 publications

Ultrasonographic findings relating to lymph node metastasis in single micropapillary thyroid cancer

Ultrasonographic findings relating to lymph node metastasis in single micropapillary thyroid cancer

Solitary lateral neck node metastasis in papillary thyroid carcinoma

Nationwide Survey on the Treatment Policy for Well-differentiated Thyroid Cancer - Results of a Questionnaire Distributed at the 37th Meeting of The Japanese Society of Thyroid Surgery -

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