Papillary thyroid carcinoma in children with Hashimoto’s thyroiditis – a review of the literature between 2000 and 2020

Sur, Maria Lucia; Gaga, Remus; Lazăr, Călin; Lazea, Cecilia; Aldea, Cornel; Sur, Daniel

doi:10.1515/jpem-2020-0383

Cited by 24 publications

(18 citation statements)

References 37 publications

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“…With regard to paediatric patients, the correlation between AIT and TC is still under discussion. Based on a review of reports published in the years 2000–2020, Sur et al concluded that the development of PTC in children with HT appeared to be higher than in the healthy population [ 38 ]. In Poland, a tenfold increase in the coexistence of AIT and TC was observed in children in the years 2001–2015 in comparison to the 15-year period before the year 2000 [ 39 ].…”

Section: Discussionmentioning

confidence: 99%

Elastographic Evaluation of Thyroid Nodules in Children and Adolescents with Hashimoto’s Thyroiditis and Nodular Goiter with Reference to Cytological and/or Histopathological Diagnosis

Borysewicz-Sańczyk

Sawicka

Bossowski

et al. 2022

JCM

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There are data indicating the coexistence of papillary thyroid carcinoma and autoimmune thyroiditis (AIT) in children. The aim of the study was elastographic evaluation of thyroid nodules in children and adolescents with AIT and nodular goiter in relation to cytological and/or histopathological diagnosis. We examined 215 children (57 boys and 158 girls) with 261 thyroid nodules (143 non-AIT and 118 AIT). All study participants underwent a conventional ultrasound examination with elastography followed by fine needle aspiration biopsy (FNAB). Abnormal Strain Ratio (SR ≥ 5) was observed in 36 non-AIT nodules and 15 AIT nodules. Papillary thyroid carcinoma was diagnosed in 5 patients (2% of all investigated nodules). SR of malignant thyroid nodules was statistically higher in comparison to SR of benign nodules both in the group of non-AIT (6 ± 4 vs. 3.67 ± 2.62, p = 0.024) and AIT nodules (6.3 ± 0.01 vs. 2.92 ± 1.89, p = 0.047). Comparison of non-AIT and AIT benign nodules revealed that SR was higher in non-AIT nodules (3.67 ± 2.62 vs. 2.92 ± 1.89, p = 0.01). We observed a strong positive correlation (R = 1) between TSH concentration and SR ratio in the group of all malignant thyroid nodules. Autoimmune inflammatory process of the thyroid gland does not limit the use of elastography in the diagnosis of thyroid nodules in children.

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Section: Discussionmentioning

confidence: 99%

Elastographic Evaluation of Thyroid Nodules in Children and Adolescents with Hashimoto’s Thyroiditis and Nodular Goiter with Reference to Cytological and/or Histopathological Diagnosis

Borysewicz-Sańczyk

Sawicka

Bossowski

et al. 2022

JCM

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“…She did not have risk factors for thyroid malignancy; hence, a clinical diagnosis of thyroid malignancy was not entertained. Whilst Hashimoto's thyroiditis (HT) is the commonest risk factor associated with paediatric PTC [ 7 ], the patient did not report any history of autoimmune disease. Furthermore, histopathological assessment of thyroid did not reveal background HT.…”

Section: Discussionmentioning

confidence: 99%

Metastatic Papillary Thyroid Carcinoma in a Paediatric Patient

Mothata

Morulana

Tshifularo

et al. 2021

Case Reports in Endocrinology

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Papillary thyroid carcinoma is the most common endocrine cancer in the paediatric population. Although the disease is diagnosed at a later stage, the prognosis is favourable. When these patients present with lymph nodal and/or pulmonary metastases, they may be initially confused for infectious diseases such as tuberculosis. Therefore, thorough clinical assessment including radiology and microbiological and histopathological assessment is important for early and correct diagnosis. We report an 11-year-old female patient who presented with cervical lymphadenopathy and the histopathological assessment confirmed metastatic papillary thyroid carcinoma. Subsequent radiological investigation revealed further metastasis to the lung. This manuscript highlights the difficulties that might be encountered in the initial management of paediatric PTC which present atypically.

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“…[43], МФ разом з іншими ознаками пухлини є незалежним і важливим чинником, що визначає прогноз виживання пацієнтів з ДРЩЗ. При ПРЩЗ МФ пухлини є незалежним чинником ризику рецидиву [24,23,115], пов'язана з агресивнішим перебігом і гіршим прогнозом [41].…”

Section: таким чином попри високу роздільну здатність сучасних апарат...unclassified

“…У дитячому віці ТХ асоціюється з підвищеною частотою ПРЩЗ [115,135]. Однак при оцінці зв'язку між агресивністю ДРЩЗ у дітей з ТХ та без нього не виявлено статистично значущих відмінностей між групами як за частотою МФ, так і за демографічними даними, ЕТП, лімфоваскулярною інвазією, метастазами у ЛВ чи легені, рецидивом захворювання або РЙТ, але пацієнти з ТХ та ДРЩЗ частіше мали МФ, менші пухлини та мікрокальцифікати [133].…”

Section: більшість досліджень демонструють що ож призводить до агреси...unclassified

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Multifocal papillary thyroid cancer in children and adults. Lecture

Tovkai¹,

Palamarchuk²,

Hryshchenko³

et al. 2022

CE&ES

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Thyroid cancer is the 9th most common cancer in the world. Thus, in the year 2020, 586.000 cases of thyroid cancer were registered worldwide. The incidence rate among women is 10.1 per 100 thousand population, and among men — 3.1 per 100 thousand population. In Ukraine, in 2019, the standardized rate of incidence of thyroid cancer (world standard) was 6.9 per 100.000 population (2.8 among men, 10.5 among women). In the structure of the incidence of malignant neoplasms of the cervical spine, thyroid cancer ranks first place among women aged 18 — 29 (19.9 %), fourth among both men aged 18 — 29 (8.3 %, and women aged 30 — 54 (8.1 %). Over the past 40 years, increased incidence of thyroid cancer (in particular, papillary thyroid cancer) is observed in most countries, which can be explained by various factors, for example, overdiagnosis, a change in the prevalence of modified risk factors. In Ukraine, in the period from 1989 to 2012, the rate of incidence of papillary thyroid cancer among men increased by 115 %, among women — by 137 %, the annual increase in incidence of papillary thyroid cancer for men and women was 5 and 6 %, respectively. Multifocality in papillary thyroid cancer is a characteristic feature that is much more common in pediatric patients than in adults, but the number of studies in children is limited, which is associated with a lower prevalence of the disease in children. The results of investigations on the multifocality predictors and its role in influencing relapse, persistence, and survival in patients with papillary thyroid cancer are conflicting in both adults and pediatric population. Among the risk factors of multifocality, a smaller number of controversies concerns the links of metastasis in the lymphatic nodes, radiation in the anamnesis, childhood age, and for bilaterality — multifocality of the primary lobe and the presence of contralateral benign nodes (in adults). Other factors as predictors of multifocality have controversial significance and deserve attention in further research. The identification of reliable predictors of multifocality, especially with the help of preoperative data analysis, as well as multifocality risk stratification will facilitate the complex decision‑making process for the correct treatment tactics of children and adults with papillary thyroid cancer.

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Papillary thyroid carcinoma in children with Hashimoto’s thyroiditis – a review of the literature between 2000 and 2020

Cited by 24 publications

References 37 publications

Elastographic Evaluation of Thyroid Nodules in Children and Adolescents with Hashimoto’s Thyroiditis and Nodular Goiter with Reference to Cytological and/or Histopathological Diagnosis

Elastographic Evaluation of Thyroid Nodules in Children and Adolescents with Hashimoto’s Thyroiditis and Nodular Goiter with Reference to Cytological and/or Histopathological Diagnosis

Metastatic Papillary Thyroid Carcinoma in a Paediatric Patient

Multifocal papillary thyroid cancer in children and adults. Lecture

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