Papillary thyroid carcinoma is a risk factor for severe osteoporosis

Notsu, Masakazu; Yamauchi, Mika; Nawata, Kiyoko; Sugimoto, Toshitsugu

doi:10.1007/s00774-019-01053-5

Cited by 9 publications

(10 citation statements)

References 27 publications

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“…Further exacerbating its toll on society, PTC is frequently diagnosed in minors and young adult populations [ 3 ]. What is more, PTC has also been previously indicated as a potential cause of osteoporosis [ 4 ]. Exposure to iodine represents the most prominent pathogenesis of severe PTC [ 5 ].…”

Section: Introductionmentioning

confidence: 99%

Transcription Factor E2F1 Exacerbates Papillary Thyroid Carcinoma Cell Growth and Invasion via Upregulation of LINC00152

Yang

Ying

Zeng

et al. 2022

Analytical Cellular Pathology

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Background. Papillary thyroid carcinoma (PTC) is the most common thyroid neoplasm, whereas transcription factor E2F1 has been previously implicated in PTC progression. The current study sought to elucidate the underlying mechanism of E2F1 in PTC cell biological activities via regulation of long intergenic noncoding RNA 152 (LINC00152). Methods. Firstly, the expression patterns of LINC00152 and E2F1 in PTC were determined. Besides, TPC-1 and IHH-4 cells were adopted to carry out a series of experiments. Cell proliferation was detected by means of a cell counting kit-8 assay and colony formation assay, while cell migration and invasion abilities were assessed using a Transwell assay. Next, the interaction between E2F1 and LINC00152 was certified. Lastly, xenograft transplantation was carried out to validate the effects of E2F1 depletion on PTC. Results. Both LINC00152 and E2F1 were highly expressed in PTC cells. Knockdown of LINC00152 led to reduced cell activity, while LINC00152 overexpression brought about the opposing trends. Likewise, E2F1 knockdown quenched cell proliferation, migration, and invasion. However, the combination of E2F1 knockdown and LINC00152 overexpression resulted in augmented cell growth. In addition, E2F1 induced LINC00152 overexpression, which accelerated cell proliferation, migration, and invasion by activating the PI3K/AKT axis, whereas the administration of LY294002, the inhibitor of PI3K, led to reversal of the same. Finally, xenograft transplantation validated that E2F1 inhibition could suppress LY294002, thereby discouraging tumor growth. Conclusion. Our findings highlighted that E2F1 augmented PTC cell proliferation and invasion by upregulating LINC00152 and the PI3K/AKT axis. Our discovery provides therapeutic implications for PTC alleviation.

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Section: Introductionmentioning

confidence: 99%

Transcription Factor E2F1 Exacerbates Papillary Thyroid Carcinoma Cell Growth and Invasion via Upregulation of LINC00152

Yang

Ying

Zeng

et al. 2022

Analytical Cellular Pathology

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“…In a population-based US study ( n = 3706), the HRs of osteoporosis were higher 1–5 years after thyroid cancer diagnoses and 5–10 years after thyroid cancer diagnoses in both the age groups <40 years and >40 years than in the control group [ 8 ]. In a small Japanese case-control study ( n = 35), the prevalence of severe osteoporosis was significantly higher in the papillary thyroid carcinoma group than in the control group (33.3% vs. 11.4%, p < 0.05) [ 10 ]. Possible causes for the association between thyroid cancer and osteoporosis are listed below.…”

Section: Discussionmentioning

confidence: 99%

“…Third, autoimmunity may link thyroid cancer and osteoporosis by activating bone resorption. PTC patients with severe osteoporosis have a higher prevalence of TPO-Ab than patients without severe osteoporosis [ 10 ]. The presence of TPO-Ab is associated with osteoporotic fractures in euthyroid postmenopausal women [ 26 ].…”

Section: Discussionmentioning

confidence: 99%

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Analyses of the Association between Thyroid Cancer and Osteoporosis/Fracture Histories: A Cross-Sectional Study Using KoGES HEXA Data

Jin

Song

Park

et al. 2021

IJERPH

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(1) Background: The purpose of this study was to determine the association among thyroid cancer, osteoporosis and fracture history. (2) Methods: The data collected from 2004 through 2016 for the Korean Genome and Epidemiology Study were retrieved. For a total of 1349 participants with thyroid cancer and 163,629 control participants, the odds ratios (ORs) with 95% confidence intervals (CIs) of osteoporosis and fracture history were evaluated using a logistic regression model. (3) Results: The adjusted ORs of osteoporosis comparing thyroid cancer with the control group were 1.41 (95% CI = 1.18–1.70, p < 0.001) for all participants and 1.43 (95% CI = 1.19–1.71, p < 0.001) for women. The adjusted ORs of fracture history comparing these two groups were not significantly associated within the entire group of participants, men only or women only. (4) Conclusions: The adjusted OR of osteoporosis was significantly higher than 1, comparing thyroid cancer with the control group, especially in women. The adjusted OR of fractures was not significantly higher than 1, comparing the thyroid cancer group with the control group.

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“…OncoTargets and Therapy 2021:14 are changes in thyroid-stimulating hormone, which is closely associated with osteogenesis. [40][41][42][43] The ECM plays an important role in the process of tumor shedding, adhesion, movement, degradation, and hyperplasias, such as prostate cancer, 44 gastric cancer, 45 breast cancer, 46 and anaplastic thyroid cancer. 47 The phosphoinositide 3-kinase-protein kinase B/AKT (PI3KPKB/AKT) pathway is one of the most prominent molecular signaling pathways implicated in cellular growth, proliferation, apoptosis, and metabolism.…”

Section: Dovepressmentioning

confidence: 99%

Identification of the EMT-Related Genes Signature for Predicting Occurrence and Progression in Thyroid Cancer

Li¹,

Jiang²,

Feng³

et al. 2021

OTT

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Background:The detection rate of thyroid cancer (TC) has been continuously improved due to the development of detection technology. Epithelial-mesenchymal transition (EMT) is thought to be closely related to the malignant progression of tumors. However, the relationship between EMT-related genes (ERGs) characteristics and the diagnosis and prognosis of TC patients has not been studied. Methods: Four datasets from Gene Expression Omnibus (GEO) were used to perform transcriptomic profile analysis. The overlapping differentially expressed ERGs (DEERGs) were analyzed using the R package "limma". Then, the hub genes, which had a higher degree, were identified by the protein-protein interaction (PPI) network. Gene expression analysis between the TC and normal data, the disease-free survival (DFS) analysis of TC patients from The Cancer Genome Atlas Thyroid Cancer (TCGA-THCA) cohort, function analysis, and immunohistochemistry (IHC) were performed to verify the importance of the hub genes. Finally, a prognostic risk scoring was constructed to predict DFS in patients with the selected genes. Results: A total of 43 DEERGs were identified and 10 DEERGs were considered hub ERGs, which had a high degree of connectivity in the PPI network. Then, the differential expressions of FN1, ITGA2, and KIT between TC and normal tissues were verified in the TCGA-THCA cohort and their protein expressions were also verified by IHC. DFS analysis indicated upregulations of FN1 expression (P<0.01) and ITGA2 expression (P<0.01) and downregulation of KIT expression (P=0.01) increased risks of decreased DFS for TCGA-THCA patients. Besides, by building a prognostic risk scoring model, we found that the DFS of TCGA-THCA patients was significantly worse in high-risk groups. Conclusion: In summary, these hub ERGs were potential biomarkers for diagnosis and prognosis of TC, which can provide a basis for further exploring the efficacy of EMT in patients with TC.

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Papillary thyroid carcinoma is a risk factor for severe osteoporosis

Cited by 9 publications

References 27 publications

Transcription Factor E2F1 Exacerbates Papillary Thyroid Carcinoma Cell Growth and Invasion via Upregulation of LINC00152

Transcription Factor E2F1 Exacerbates Papillary Thyroid Carcinoma Cell Growth and Invasion via Upregulation of LINC00152

Analyses of the Association between Thyroid Cancer and Osteoporosis/Fracture Histories: A Cross-Sectional Study Using KoGES HEXA Data

Identification of the EMT-Related Genes Signature for Predicting Occurrence and Progression in Thyroid Cancer

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