HPV infections are caused by human papillomaviruses. These viruses create cutaneous or mucous membrane tumors, including some warts. Warts are extremely common and easy to recognize, but when the location is atypical, histological confirmation is required. We report a HPV infection case localized in the ear's external auditory canal in a 30-year-old young that is admitted to the ENT department of the Ziguinchor Peace Hospital. The examination found: auricular pruritus, a full ear feeling and a mass of the right ear's external auditory canal, evolving for about 3 months. Histological examination confirms the papilloma by showing a specific cytopathogenic effect in keratinocytes (koilocytes). Our patient underwent surgical resection of the mass with no relapse after 3 months.