Papillomatosis of the Bladder: New Conceptions of Etiology and Treatment

Kirwin, Thomas J.

doi:10.1016/s0022-5347(17)70514-9

Cited by 12 publications

(2 citation statements)

References 5 publications

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“…Several investigators have suggested a role for papovaviruses in bladder tumors. Soon after the discovery of the Shope papilloma virus in rabbits, Kirwin speculated that a similar virus may be responsible for urinary bladder cancer in man (Kirwin, 1943). Olson has reported the isolation of bovine wart virus from naturally occurring bladder tumors of cattle (Olson et al, 1965).…”

Section: Discussionmentioning

confidence: 99%

The occurrence of SV40‐neutralizing antibodies in sera of patients with genitourinary carcinoma

Shah

Palma

Murphy

1971

Journal of Surgical Oncology

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Neutralizing antibodies to simian virus 40 (SV40) were detected in sera of seven of 182 patients studied a t the Roswell Park Memorial Institute. Four of 91 (4.4%) bladder tumor patients, two of 24 (8.3%) patients with prostatic carcinoma, and one of four patients with testicular tumors had antibodies. Neutralizing antibodies were demonstrable in repeated bleedings over a 5-11 month period. T antibodies were not detected in any of the sera. None of the antibody-positive patients gave a history of immunization with (potentially SV40-contaminated) poliovirus vaccines, the only known source of major human exposure to SV40 in the United States. These findings suggest that the seven antibody-positive donors were infected with a virus cross-reacting with SV40 or that infection with SV40 may have occurred in some unknown manner.

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Section: Discussionmentioning

confidence: 99%

The occurrence of SV40‐neutralizing antibodies in sera of patients with genitourinary carcinoma

Shah

Palma

Murphy

1971

Journal of Surgical Oncology

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“…

Tumour cell implantation is widely believed to be a factor in the aetiology of multiple urothelial tumours (Kirwin, 1943; Hinman, 1960;Boyd and Burnand, 1974). If implantation is a factor and if the number of tumour cells floating free within the bladder is increased as a result of cystodiathermy, then the destruction of these cells should reduce the incidence of recurrent tumour formation.This paper reports a prospective randomised trial in which the cytotoxic agent thiotepa (triethylene thio-phosphoramide) was introduced into the bladder immediately after cystodiathermy.

…”

mentioning

confidence: 99%

Single Dose Intravesical Thiotepa as an Adjuvant to Cystodiathermy in the Treatment of Transitional Cell Bladder Carcinoma

Burnand

Boyd

Mayo

et al. 1976

British Journal of Urology

130

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Tumour cell implantation may be a factor in the aetiology of recurrent well-differentiated superficial bladder tumours. A prospective trial is reported in which single dose intravesical thiotepa was administered to a group of randomly selected patients immediately after cystodiathermy. A control group of patients was treated by cystodiathermy alone and tumour recurrence in the 2 groups was compared. Significantly fewer patients in the thiotepa-treated group developed recurrent tumour and there was also a significantly reduced incidence of pure vault recurrence in this group. The beneficial effects of adjuvant thiotepa were apparent after 1 treatment. In this series of patients no benefit resulted from the continued use of adjuvant thiotepa once a patient developed a recurrent tumor.

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Primary benign and malignant tumors of the ureter

Abeshouse

1956

The American Journal of Surgery

142

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Papillomatosis of the Bladder: New Conceptions of Etiology and Treatment

Cited by 12 publications

References 5 publications

The occurrence of SV40‐neutralizing antibodies in sera of patients with genitourinary carcinoma

The occurrence of SV40‐neutralizing antibodies in sera of patients with genitourinary carcinoma

Single Dose Intravesical Thiotepa as an Adjuvant to Cystodiathermy in the Treatment of Transitional Cell Bladder Carcinoma

Primary benign and malignant tumors of the ureter

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