Papillomaviral Carcinogenesis. Major Achievements and Certain Challenges Part 2. HPV-Associated Cancers in Russia. Preventive HPV Vaccines

Волгарева, Г. М.

doi:10.17650/1726-9784-2019-19-2-31-38

Cited by 4 publications

(1 citation statement)

References 35 publications

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“…К настоящему времени для предупреждения распространенного онкологического заболевания женщин -рака шейки матки (РШМ) -созданы 3 вакцины, способные, предположительно, предупредить от 70 до 90 % случаев РШМ; судя по первым результатам, эти вакцины успешно используются для профилактики аногенитальных бородавок и предраковых изменений в эпителии шейки матки; они рекомендованы для прививок не только девочек, но и мальчиков [3][4][5][6]. Две из этих вакцин рекомендованы к применению в России.…”

Section: Introductionunclassified

Oncogenic papillomaviruses: reproductive problems in infected males

Волгарева

2021

Rossijskij bioterapevtičeskij žurnal

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Human papillomaviruses (HPV) of the high-risk types cause carcinomas in cervix uteri, vulva, vagina, penis, anus, as well as in certain sites of head and neck – oral cavity, oropharynx, tonsils, larynx. HPV of types 16 and 18 are the most widespread ones. Papillomaviruses of low oncogenic risk, HPV of types 6 and 11, cause recurrent respiratory papillomatosis and anogenital warts. Preventive vaccinations against HPV are not included into the National mandatory immunization schedule in Russia; however, they are being executed in several country areas in a form of regional programs. Substantial contingents are not embraced by the procedures as yet. A family can make decision of its own whether to vaccinate the adolescent child on paid basis. To make decision in favor of vaccination complete awareness is needful on the HPV infection consequences. As far as viruses of the given group became primarily known as cervical cancer etiological agents certain risk persists of “feminization” of notions about unfavorable effects of the HPV infection thus resulting in debates on usefulness of boys’ preventive vaccination.In this connection the purpose of the review was consideration of HPV effects on male reproductive potential. Oncogenic HPVs are frequently found in healthy donors’ sperm. HPV DNA can penetrate from sperm into oocyte under experimental conditions. Seminal fluid of HPV-positive males is a storage tank of the virus as well as the source of its distribution throughout population. DNA of oncogenic HPV was detected in endosomes of seminal lymphocytes. The latter fact opposes the canonic notion of strict HPV epitheliotropy. Correlation exists between the seminal fluid HPV-positivity of a certain man and his fertility drop. Reproductologists believe failures of some married couples when using assisted reproductive technologies may result from partner’s seminal HPV positivity. The successful attempt is known of semen parameters’ normalization in men with reduced fertility after inoculation with the quadrivalent Gardasil vaccine.It seems reasonable to consider the data on unfavorable effects of HPV infection on male reproductive potential as an argument for boys’ preventive HPV vaccination. It would help not only to prevent the HPV-associated oncological diseases in men but the distribution of the given infection around the population as a whole; it would contribute to more successes in solving demographic problems.

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Section: Introductionunclassified

Oncogenic papillomaviruses: reproductive problems in infected males

Волгарева

2021

Rossijskij bioterapevtičeskij žurnal

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Hygienic requirements regarding to population safety for cancirogenic factors of biological nature (a review)

Chekhomov,

Eliseev

2024

Saratov J Med Sci Res

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Objective: to identify the main trigger mechanisms of carcinogenic factors of biological nature and develop, on their basis, preventive measures to prevent the development of cancer in the population. Methodology for writing a review. A review 50 scientific papers posted in the databases Web of Science, Scopus, PubMed, CyberLeninka, eLibrary.ru were analyzed. The electronic search was carried out using a combination of keywords: "carcinogenic factors of biological nature", "viruses", "bacteria", "trematodes", "preventive work", "sanitary service", "oncological morality". The depth of searches in electronic databases and citation lists amounted to more than a 10-year period from 2013 to the middle of 2024. Conclusion. An analysis of the scientific literature showed that the trigger mechanisms in the pathogenesis of the formation of EIT caused by carcinogenic factors of biological nature lie in the ability of infectious pathogens to cause inflammatory reactions, turning into chronic infections that provoke the development of cancer among the infected population. Preventive measures, in the absence of specific vaccination, can be presented in the form of a set of preventive measures aimed at ensuring the sanitary, hygienic and anti-epidemiological well-being of the population.

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Papillomaviral Carcinogenesis. Significant Achievements and Specific Challenges. Part 3. Three Levels of Cervical Cancer Prevention and Treatment

Волгарева

2020

Rossijskij bioterapevtičeskij žurnal

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Efficient prophylactic vaccines have been developed to prevent cervical cancer, a frequent female oncological disease caused by carcinogenic human papillomaviruses. World Health Organization worked out the program for prophylaxis of cervical cancer and control of the disease. It includes preventive adolescent vaccinations, screening of precancerous cervical lesions in women as well as cervical cancer treatment if originated. Cervical cancer diagnostics is being improved, development of therapeutic human papillomaviruses vaccines is in progress. The review deals with major achievements and certain challenges in the field of cervical cancer prevention.Part I see: Volgareva G.M. Papillomaviral carcinogenesis. Major achievements and certain challenges. Part I. General notions of papillomaviruses. Human papillomavirusesassociated cancers. Russian Journal of Biotherapy 2020;19(1):6–12.Part 2 see: Volgareva G.M. Papillomaviral carcinogenesis. Major achievements and certain challenges. Part 2. HPV-associated cancers in Russia. Preventive HPV vaccines. Russian Journal of Biotherapy 2020;19(2):31–8.

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Papillomaviral Carcinogenesis. Major Achievements and Certain Challenges Part 2. HPV-Associated Cancers in Russia. Preventive HPV Vaccines

Cited by 4 publications

References 35 publications

Oncogenic papillomaviruses: reproductive problems in infected males

Oncogenic papillomaviruses: reproductive problems in infected males

Hygienic requirements regarding to population safety for cancirogenic factors of biological nature (a review)

Papillomaviral Carcinogenesis. Significant Achievements and Specific Challenges. Part 3. Three Levels of Cervical Cancer Prevention and Treatment

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