Papillomavirus-Associated Diseases

Torres, Sheila M. F.; Koch, Sandra N.

doi:10.1016/j.cveq.2013.08.003

Cited by 26 publications

(61 citation statements)

References 24 publications

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“…Seven equine papillomaviruses (EcPV1–7) have been identified and their genomes sequenced . Most equine PVs have been consistently associated with one of three characteristic clinical presentations, which are commonly referred to as classic viral papillomatosis (EcPV1), genital papillomas (EcPV2) and aural plaques (EcPV3–6) . One virus, EcPV7, was identified in swabs of penile masses in a single horse .…”

Section: Introductionmentioning

confidence: 99%

Generalized papillomatosis in three horses associated with a novel equine papillomavirus (EcPV8)

Linder

Bizikova

Luff

et al. 2017

Veterinary Dermatology

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Section: Introductionmentioning

confidence: 99%

Generalized papillomatosis in three horses associated with a novel equine papillomavirus (EcPV8)

Linder

Bizikova

Luff

et al. 2017

Veterinary Dermatology

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“…Viral papillomatosis is common in horses and frequently observed in young horses of less than 3 years [10]. The resulting warts are most common on the muzzle, genitalia, ears and distal legs.…”

Section: Discussionmentioning

confidence: 99%

“…Because the viruses cannot actively penetrate the skin of their hosts, abrasion is one of the prerequisites for PV infection [10]. The autoimmune skin disease of the stallion led to abundant skin lesions and provided an appropriate primary surface for viral infection.…”

Section: Discussionmentioning

confidence: 99%

“…To date, almost 200 distinct papilloma viruses have been cloned, sequenced, and allocated to various genera, including seven viruses termed EcPV1-7 that were identified in equine papillomas [7][8][9]. The papillomavirus genome is organized in 3 regions: a) a region coding for early (E) and functional proteins (E1-E7), b) a region encoding the late (L) capsid proteins (L1 and L2), and c) a region required for genome replication and transcription (LCR (long control region)) [10]. Papillomavirus group-specific antigens have been detected in papillomas by the peroxidase-antiperoxidase (PAP) technique in retrospective studies on equine tumors [11,12].…”

Section: Introductionmentioning

confidence: 99%

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Investigation of a Putative Novel Papillomavirus that causes InvertedPapillomas in Horses

Ertelt¹,

Kershaw²,

Förster³

et al. 2017

Virol Mycol

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The Papillomaviridae family comprises a large number of viruses that can infect a broad range of hosts giving rise to benign lesions of the skin or mucosal membranes. Until today, seven viruses termed EcPV1-7 were identified in equine papillomas.Two trotter stallion siblings at the age of two were referred to the Equine Clinic of Free University of Berlin, because of erythema, alopecia and crusting. After a diagnosis of immune-mediated skin disease, the horses underwent long-term treatment with glucocorticoids and azathioprine. Two months later, both horses developed hundreds of small wart-like proliferations on the head, neck, chest and trunk. Six healthy horses, housed in the same stable, were used to assess the occurrence of the virus in healthy skin.Biopsies were obtained for histopathology and for amplification and cloning of the papillomavirus genome as well as for sequence analysis.Histopathology revealed well demarcated cup-shaped epidermal proliferations. Foci were covered by parakeratotic, or abnormally formed, keratin. In deeper layers, numerous enlarged cells with cytoplasmic eosinophilic inclusion-like structures and occasional intranuclear basophilic inclusion bodies were striking, existing beside cells with a peripheral cytoplasmic clearing (koilocytes). Histopathological findings were consistent with endophytic papilloma similar to the Le Net-type described in immunosuppressed dogs caused by a distinct canine papillomavirus. Furthermore, papillomavirus DNA was detected in tissue samples using a broad range PCR analysis. Preliminary phylogenetic analysis of a partial sequence from the L1 gene indicated a putative new papillomavirus that has not been described in horses so far. Biopsies of the control horses showed no abnormalities in histopathology and were tested negative for the putative novel papilloma virus DNA.

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“…Until recently, attention focused on possible oncogenic effects of chronic inflammation, UV exposure and smegma accumulation [80]. The discovery of a novel papilloma virus, EcPV-2 [79] and its association with equine penile SCC [79,80] along with the histopathological finding that benign penile papillomas (from which EcPV-2 has also been isolated) can transition to SCC [107][108][109] suggest a causal role for papillomavirus in this cancer.…”

Section: (C) Associations Between Benign and Malignant Neoplasiasmentioning

confidence: 99%

Infection and cancer in multicellular organisms

Ewald

2015

Phil. Trans. R. Soc. B

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Evolutionary considerations suggest that oncogenic infections should be pervasive among animal species. Infection-associated cancers are well documented in humans and domestic animals, less commonly reported in undomesticated captive animals, and rarely documented in nature. In this paper, we review the literature associating infectious agents with cancer to evaluate the reasons for this pattern. Non-malignant infectious neoplasms occur pervasively in multicellular life, but oncogenic progression to malignancy is often uncertain. Evidence from humans and domestic animals shows that non-malignant infectious neoplasms can develop into cancer, although generally with low frequency. Malignant neoplasms could be difficult to find in nature because of a low frequency of oncogenic transformation, short survival after malignancy and reduced survival prior to malignancy. Moreover, the evaluation of malignancy can be ambiguous in nature, because criteria for malignancy may be difficult to apply consistently across species. The information available in the literature therefore does not allow for a definitive assessment of the pervasiveness of infectious cancers in nature, but the presence of infectious neoplasias and knowledge about the progression of benign neoplasias to cancer is consistent with a widespread but largely undetected occurrence.

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Papillomavirus-Associated Diseases

Cited by 26 publications

References 24 publications

Generalized papillomatosis in three horses associated with a novel equine papillomavirus (EcPV8)

Generalized papillomatosis in three horses associated with a novel equine papillomavirus (EcPV8)

Investigation of a Putative Novel Papillomavirus that causes InvertedPapillomas in Horses

Infection and cancer in multicellular organisms

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