Papillomavirus‐associated multicentric squamous cell carcinoma <i>in situ</i> in a cat: an unusually extensive and progressive case with subsequent metastasis

Ravens, Philippa A.; Vogelnest, Linda; Tong, Lydia; Demos, Lauren E.; Bennett, Mark D.

doi:10.1111/vde.12080

Cited by 26 publications

(30 citation statements)

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“…PCR and sequence analysis using DNA extracted from shavings of the PEFF biopsy material is a valuable technique to confirm a diagnosis of this disease. Similar conclusions could be drawn from the Devon Rex cat described in the paper by Ravens et al (2013), where an early case of feline papillomavirus-induced Bowenoid in situ carcinoma was probably misdiagnosed, and later progressed to SCC, and ultimately a fatal outcome.…”

Section: Discussionsupporting

confidence: 80%

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Progressive cutaneous viral pigmented plaques in three Hungarian Vizslas and the response of lesions to topical tigilanol tiglate gel

Hansen

Nicholas²,

Pack³

et al. 2017

Veterinary Medicine & Sci

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Cutaneous pigmented viral plaques is a disorder of epidermal growth caused by canine papillomavirus type 4 (CPV‐4). There is currently no standard of care for managing this condition and it has not been reported in the Hungarian Vizsla. This case series documents the clinical features of canine pigmented viral plaques in Hungarian Vizsla dogs and the treatment of a severe case using a novel topical agent tigilanol tiglate (EBC‐46). A 4‐year‐old spayed Hungarian Vizsla in Australia was presented for multiple cutaneous pigmented plaques extending from the ventral cervical region. Lesions were neither painful nor pruritic. The number and size of these sessile plaques increased over time, with the largest lesions eventually taking on an exophytic (wart‐like) appearance. These lesions did not affect the dog's wellbeing. Two much less severe cases in a 5‐year‐old Vizsla from the UK and a 7‐year‐old Vizsla from New Zealand were also diagnosed. Histology was consistent with papillomavirus‐induced pigmented plaques and CPV‐4 DNA sequences were amplified from paraffin‐embedded formalin‐fixed tissue using the polymerase chain reaction from the most severely affected patient. Topical imiquimod was ineffective although used for only a short time. Two topical applications of novel anti‐neoplastic diterpene ester tigilanol tiglate as a gel, 9 days apart, greatly reduced the size and number of lesions in a limited portion of skin treated, over the lateral hock. While CPV‐4 has been previously reported to cause pigmented plaques, most commonly on pug dogs, but sporadically on other breeds, this is the first report of this virus causing plaques in Hungarian Vizslas. The cases illustrate some of the difficulties in diagnosing papillomavirus‐induced disease in dogs, especially in its early stages. Topical tigilanol tiglate is a potentially useful topical therapy for this viral‐induced disorder of cell growth and represents a treatment deserving of further investigation.

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Section: Discussionsupporting

confidence: 80%

“…Similar conclusions could be drawn from the Devon Rex cat described in the paper by Ravens et al . (), where an early case of feline papillomavirus‐induced Bowenoid in situ carcinoma was probably misdiagnosed, and later progressed to SCC, and ultimately a fatal outcome.…”

Section: Discussionmentioning

confidence: 99%

Progressive cutaneous viral pigmented plaques in three Hungarian Vizslas and the response of lesions to topical tigilanol tiglate gel

Hansen

Nicholas²,

Pack³

et al. 2017

Veterinary Medicine & Sci

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“…Devon Rex, and the closely related Sphinx, cats may be predisposed to BISCs, and BISCs in cats of these breeds are often rapidly progressive. 15 A 17-year-old female Domestic Shorthair cat was presented to the primary care veterinarian because of a slightly raised 0.5 cm in diameter interscapular skin mass of uncertain duration.…”

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confidence: 99%

The detection of Felis catus papillomavirus 3 DNA in a feline bowenoid in situ carcinoma with novel histologic features and benign clinical behavior

2016

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Brief CommunicationPapillomaviruses (PVs) are highly species-specific epitheliotropic DNA viruses. As part of their normal replication, PVs produce oncoproteins that disrupt normal cell regulation. 1 The vast majority of PV infections either do not result in the development of a visible lesion or cause a self-resolving hyperplastic wart. 7 However, the oncogenes produced by a small number of PV types can predispose an infected cell to neoplastic transformation. 1Disease resulting from PV infection is considered uncommon in cats. 8 To date, the disease that is most strongly associated with PV infection in cats is bowenoid in situ carcinoma (BISC; papillomavirus-associated squamous cell carcinoma in situ). 9,13 This neoplasm typically occurs as single or multiple scaly or crusting lesions within haired skin, especially around the head and neck. 4 Cats with BISCs may require euthanasia either because of the development of multiple BISCs or because of progression of a BISC to a squamous cell carcinoma (SCC). Devon Rex, and the closely related Sphinx, cats may be predisposed to BISCs, and BISCs in cats of these breeds are often rapidly progressive. 15A 17-year-old female Domestic Shorthair cat was presented to the primary care veterinarian because of a slightly raised 0.5 cm in diameter interscapular skin mass of uncertain duration.No tests were performed at this time, and a post-injection inflammatory reaction was suspected because the cat had received multiple subcutaneous injections at this location for the management of previously diagnosed diabetes mellitus and chronic renal failure. The mass was reported to have enlarged slowly, and 18 months later had doubled in size to 1 cm in diameter. The cat had no other skin lesions. The mass was surgically removed with 1-cm margins and submitted for histologic examination.On histologic examination, normal epidermis merged abruptly with a well-demarcated focus of marked, irregular epidermal hyperplasia. There were multiple, broad, downward-projecting rete pegs confined by the basement membrane and accompanying mild parakeratosis, hyperkeratosis, and variable melanization. The epidermal hyperplasia also Abstract. Bowenoid in situ carcinoma (BISC; papillomavirus-associated squamous cell carcinoma in situ) is an uncommon skin neoplasm of cats that can result in euthanasia because of the development of multiple lesions or because of progression to invasive squamous cell carcinoma. BISCs are currently thought to be caused by Felis catus papillomavirus 2 (FcaPV-2). The presently described cat developed a single 0.5 cm in diameter interscapular mass. Over the following 18 months, the mass doubled in size; no additional lesions developed. The mass was surgically excised and histologically diagnosed as a BISC. However, in contrast to previously reported BISCs, neither prominent thickening of the deep aspects of the follicular infundibula nor marked cell dysplasia were present. Furthermore, ~50% of the keratinocytes in the affected epidermis had prominent PV cytopathic changes that...

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“…FcaPV3 is another Taupapillomavirus , first isolated from a cutaneous in situ carcinoma (Munday et al., ). FcaPV2, a Dyothetapapilomavirus , was isolated from a cutaneous pigmented plaque (Lange et al., ), but was later associated with cutaneous SCC (Ravens et al., ; Munday, ; Altamura et al., ). Recently FcaPV‐2 was detected in a single oral SCC.…”

Section: Papillomavirus In Companion Animals: Which Viruses Cause Whimentioning

confidence: 99%

An Update on Canine, Feline and Bovine Papillomaviruses

Costa

Peleteiro

Pires

et al. 2016

Transbound Emerg Dis

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Over recent years, a growing number of papillomaviruses have been identified, which cause a wide range of lesions in domestic and wild animals. Papillomavirus-induced lesions may have a great impact on animal health, and some diseases observed in farm animals are associated with significant economic losses. This concise review brings together recent advancements on animal papillomavirus research, providing the scientific community and veterinary practitioners with an update on this rapidly evolving field. Among others, bovine, canine and feline papillomaviruses (BPV, CPV and FcaPV) are most extensively discussed, in view of the recent discovery of new viral types and their worldwide importance for animal health. Feline papillomaviruses 2 is an emerging, highly prevalent pathogen in domestic cats, associated with a subset of malignant skin lesions. Aspects related to cross-species infection by BPV and its environmental co-factors are also addressed. Animal papillomaviruses are also fascinating models for studying molecular and cell biology and have recently inspired some major breakthroughs. Overall, it is clear that additional, international and systematic efforts are needed to clarify which lesions are caused by which viral types and to develop experimental models for studying animal papillomavirus.

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Papillomavirus‐associated multicentric squamous cell carcinoma in situ in a cat: an unusually extensive and progressive case with subsequent metastasis

Abstract: This case represents an unusual presentation of papillomavirus-associated MSCCIS with extensive lesions, atypical initial histopathology and progression to SCC with distant metastases.

Cited by 26 publications

References 12 publications

Progressive cutaneous viral pigmented plaques in three Hungarian Vizslas and the response of lesions to topical tigilanol tiglate gel

Progressive cutaneous viral pigmented plaques in three Hungarian Vizslas and the response of lesions to topical tigilanol tiglate gel

The detection of Felis catus papillomavirus 3 DNA in a feline bowenoid in situ carcinoma with novel histologic features and benign clinical behavior

An Update on Canine, Feline and Bovine Papillomaviruses

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