Papillomavirus, p53 Alteration, and Primary Carcinoma of the Vulva

Pilotti, Silvana; D'Amato, Lucia; G, Della Torre; Donghi, R.; Longoni, Alberto; Giarola, Monica; Sampietro, Gianluca; G, De Palo; Ma, Pierotti; Rilke, F

doi:10.1097/00019606-199512000-00003

Cited by 40 publications

(18 citation statements)

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“…In other carcinomas, the Bcl‐2 protein has been shown to correlate inversely with p53 protein expression, suggesting p53 transcriptionally represses the Bcl‐2 gene (15) . However, no Bcl‐2 expression was found in the samples in this study, a result consistent with other studies of vulvar lesions (16) .…”

Section: Discussionsupporting

confidence: 92%

Cell cycle proteins as molecular markers of malignant change in vulvar lichen sclerosus

Rolfe¹,

Eva²,

Maclean³

et al. 2001

Int J Gynecol Cancer

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Lichen sclerosus (LS) has a known association with the development of squamous cell carcinoma of the vulva. The purpose of this study was to investigate molecular markers, which could indicate premalignant changes. Multiple sequential vulvar biopsies were taken over a period of 11 years from a patient with longstanding LS. Immunohistochemical staining was used to demonstrate a range of molecular markers. Increased expression of p53 and Ki67 was found in areas of squamous hyperplasia (SH) and differentiated vulvar intraepithelial neoplasia (dVIN) which correlated with the subsequent development of invasive squamous cell carcinoma (SCC). Molecular changes have been found to accompany histologic changes in the progression of vulvar LS to malignancy. Such markers may prove a useful addition in the clinical management of these conditions.

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Section: Discussionsupporting

confidence: 92%

Cell cycle proteins as molecular markers of malignant change in vulvar lichen sclerosus

Rolfe¹,

Eva²,

Maclean³

et al. 2001

Int J Gynecol Cancer

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“…A meta‐analysis and literature review revealed a low percentage of aberrant p53 in VIN, namely 7% in lone VIN and 25% in VIN associated with SCC 15 . p53 staining in lone VIN ranged from 0% 16,17 to 12% 14 and in VIN associated with vulvar SCC from 5 to 52% (for review see 15 ). Mutations of the p53 gene occur late in the progression of vulvar tumorigenesis.…”

Section: Discussionmentioning

confidence: 99%

p53 immunostaining in lichen sclerosus is related to ischaemic stress and is not a marker of differentiated vulvar intraepithelial neoplasia (d‐VIN)

Liegl

Regauer

2006

Histopathology

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“…Further mutations, perhaps involving p53 , or exposure to HPV may then precipitate the development of definitive neoplasia. Increased levels of p53 have been found in vulval SCC, vulval LS, and VIN3, 18–20 but do not seem to be directly linked to HPV positivity. 21 …”

Section: Discussionmentioning

confidence: 92%