Papillomaviruses in ruminants: An update

Daudt, Cíntia; Silva, F. R. C. Da; Lunardi, Michele; Alves, C. B. D. T.; Weber, Matheus Nunes; Cibulski, Samuel Paulo; Alfieri, Amauri Alcindo; Canal, Cláudio Wageck

doi:10.1111/tbed.12868

Cited by 61 publications

(60 citation statements)

References 91 publications

(237 reference statements)

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“…A total of 57% of the samples analysed showed similarity with viral type BPV2, which is associated with tumours in the urinary tract (Borzacchiello et al, 2007;Balcos et al, 2008;Resendes et al, 2011). This viral type has the greatest geographic distribution and has been reported in countries such as Germany, Brazil, New Zealand, Japan, India, Italy, Turkey and Korea and isolated from cutaneous papillomas, pulmonary fibromatosis, bladder, semen, blood, milk and urine (Daudt et al, 2018). These samples related to BPV2 Figure 2.…”

Section: Resultsmentioning

confidence: 94%

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First report of bovine papillomavirus genotypes in cutaneous lesions by polymerase chain reaction (PCR) and direct sequencing in Panama

GonzÃ¡lez¹,

Murillo²,

Castillo³

et al. 2019

Afr. J. Biotechnol.

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Bovine papillomavirus (BPV) causes benign tumours in the mucosal and cutaneous epithelium and is characterized by the presence of warts. The present study includes the molecular identification of BPV strains in samples of warts using degenerate polymerase chain reaction (PCR) primers FAP59/64. Skin biopsies were taken from crossbred cattle from two experimental farms of Instituto de Investigación Agropecuaria de Panamá (IDIAP) during the period from July 2016 to February 2018. Fourteen samples were positive by PCR amplification and sequenced at the laboratory of the Institute of Legal Medicine and Forensic Sciences (IMELCF). The analysis of the sequences allowed the identification of strains related to seven viral types; this was the first time that this type of study was carried out in Panama. The present study showed that PCR amplification with the primers FAP59/64, which partially amplify the L1 gene, followed by direct sequencing was useful for genotyping BPV. This study possibly identified local strains of BPV2 and BBA2; however, it is necessary to carry out more studies to establish the diversity and distribution of this virus in the country. The results in this study are important for the development of prophylactic and therapeutic measures that contribute to reducing the economic losses associated with BPV in Panama.

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Section: Resultsmentioning

confidence: 94%

“…BPV1 and BPV2 have also been identified from equine sarcoids in horses as a result of transmission between species (Ataseven et al, 2016;Daudt et al, 2018).…”

Section: Introductionmentioning

confidence: 99%

First report of bovine papillomavirus genotypes in cutaneous lesions by polymerase chain reaction (PCR) and direct sequencing in Panama

GonzÃ¡lez¹,

Murillo²,

Castillo³

et al. 2019

Afr. J. Biotechnol.

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“…The Xipapillomavirus genus has two species: Xipapillomavirus 1 (BPV-3, BPV-4, BPV-6, BVP-9, BPV-10, BPV-11, and BPV-15) and Xipapillomavirus 2 (BPV-12). The other two genus are Epsilonpapillomavirus 1 (BPV-5 and BPV-8) and Dyoxypapillomavirus 1 (BPV-7) [ 1 , 10 , 11 , 12 , 13 ]. Lastly, two recently described types (BPV-17) and BPV-20) are still unclassified as species.…”

Section: Introductionmentioning

confidence: 99%

Molecular Characterization and Developing a Point-of-Need Molecular Test for Diagnosis of Bovine Papillomavirus (BPV) Type 1 in Cattle from Egypt

El‐Tholoth

Mauk

Elnaker

et al. 2020

Animals

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Bovine papillomatosis is a viral disease of cattle causing cutaneous warts. A diagnosis of this viral infection is very mandatory for combating the resulting economic losses. Given the limited data available about bovine papillomavirus (BPV) in Egypt, the present study involved the molecular diagnosis of bovine papillomavirus type-1 (BPV-1), -2, -4, -5, and -10 in cattle presenting cutaneous warts on the head and neck from New Valley Province, Egypt. The phylogenetic analysis of the detected types of BPV was also performed, followed by developing a point-of-need molecular assay for the rapid identification of identified BPV types. In this regard, a total of 308 cattle from private farms in Egypt were clinically examined, of which 13 animals presented cutaneous warts due to suspected BPV infection. The symptomatic animals were treated surgically, and biopsies from skin lesions were collected for BPV-1, -2, -4, -5, and -10 molecular identification using polymerase chain reaction (PCR). The presence of BPV-1 DNA was confirmed in 11 collected samples (84.6%), while BPV-2, -4, -5, and -10 were not detected. Sequencing of the PCR products suggested the Egyptian virus is closely related to BPV found in India. An isothermal nucleic acid amplification test (NAAT) with labeled primers specific for the BPV-1 L1 gene sequence, and based on recombinase polymerase amplification (RPA), in combination with a lateral flow strip assay for the detection of RPA products, was developed and tested. The point-of-need molecular assay demonstrated a diagnostic utility comparable to PCR-based testing. Taken together, the present study provides interesting molecular data related to the occurrence of BPV-1 in Egypt and reveals the genetic relatedness of the Egyptian BPV-1 with BPV-1 found in buffalo in India. In addition, a simple, low-cost combined test was also validated for diagnosis of the infection. The present study suggests the necessity of future investigations about the circulating strains of the virus among the cattle in Egypt to assess their genetic relatedness and better understand the epidemiological pattern of the disease.

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“…Almost half of these genomes are of animal origin, including those of viruses from cervid species. Most of these viruses are species-specific [5,6], but cross-infections have also been reported [5,[7][8][9]. It was reported that some animal species are often infected by PVs belonging to different taxonomic groups [10][11][12].…”

Section: Introductionmentioning

confidence: 99%

“…PVs are responsible for skin and mucosa infections of humans and various animals, in which they can appear asymptomatic or cause different neoplastic changes, ranging from self-limited warts to cancers [5,10,12,13]. In cervids, most of the detected PVs belong to the Deltapapillomavirus genus and cause neoplastic changes described as fibromas, papillomas, fibropapillomas or warts [15].…”

Section: Introductionmentioning

confidence: 99%

A Comprehensive Study of Cutaneous Fibropapillomatosis in Free-Ranging Roe Deer (Capreolus capreolus) and Red Deer (Cervus elaphus): from Clinical Manifestations to Whole-Genome Sequencing of Papillomaviruses

Kmetec

Kuhar

Fajfar

et al. 2020

Viruses

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Papillomaviruses (PVs) are an extremely large group of viruses that cause skin and mucosa infections in humans and various animals. In roe deer and red deer, most PVs belong to the Deltapapillomavirus genus and cause neoplastic changes that are generally described as fibropapillomas. Despite the wide distribution of roe and red deer throughout Europe and beyond, the data in the scientific literature regarding the widespread distribution of PVs and the genetic variability of PV genomes in these species are rather scarce. This study describes cutaneous fibropapillomatosis cases in roe and red deer with clinical manifestations that are typical of infections with PVs. In all cases, the presence of PV DNA was confirmed using PCR, followed by Sanger sequencing of the partial L1 gene. The complete PV genomes were determined in all the investigated samples using next-generation sequencing technology, revealing infections of roe deer with the CcaPV1-type and red deer with the CePV1v-type variant. A comparison of the complete CcaPV1-type and CePV1v-type variant genome sequences reported here with already available complete genome sequences in GenBank revealed their great genetic stability across time and space.

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Papillomaviruses in ruminants: An update

Cited by 61 publications

References 91 publications

First report of bovine papillomavirus genotypes in cutaneous lesions by polymerase chain reaction (PCR) and direct sequencing in Panama

First report of bovine papillomavirus genotypes in cutaneous lesions by polymerase chain reaction (PCR) and direct sequencing in Panama

Molecular Characterization and Developing a Point-of-Need Molecular Test for Diagnosis of Bovine Papillomavirus (BPV) Type 1 in Cattle from Egypt

A Comprehensive Study of Cutaneous Fibropapillomatosis in Free-Ranging Roe Deer (Capreolus capreolus) and Red Deer (Cervus elaphus): from Clinical Manifestations to Whole-Genome Sequencing of Papillomaviruses

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