Papilomatosis respiratoria recurrente en paciente pediátrico: reporte de un caso

Abstract

Introduction: Genetic variability related to the host immune system has been proposed as one of the most influential factors in the development of diseases caused by HPV. Clinical case: We report the case of a 5-year-old child in whom chronic laryngeal papillomatosis, probably acquired vertically during labor, was detected. The diagnosis of laryngeal papillomatosis was confirmed with a biopsy after a first surgery to remove the papillomas. The Derkay classification system was used to assess the severity of papillomatosis. Biopsy genotyping was performed by demonstrating HPV-6. Later, HLAD-QA1*0505, -DQB1*0301, -DRB1*1101 alleles were homozygous for HLA allele typing. Conclusions: Further studies are needed to identify the most prevalent HLA alleles in the Latino population and their potential association with genetic susceptibility in Recurrent Respiratory Papillomatosis.

Exploring Recurrent Respiratory Papillomatosis: A Mini-Review

“…Available literatures have shown diverse results in terms of sex predilection in RRP. Most studies have concluded Juvenile Onset RRP to affect males and females in equal predominance but the Adult Onset RRP affects males than females [1][2][3][4]. A different picture is depicted in the adult form of RRP where males are more affected than females.…”

“…Recurrent Respiratory Papillomatosis is a rare disease characterized by recurrent growth of benign papillomatous lesions in the respiratory tree of both adults and children with the exclusive aetiology being Human papillomavirus [1][2][3][4]. Such lesions may occur anywhere in the upper aerodigestive tract [5] though in most occasions affect the larynx and that's why some literatures describe such disease condition to be "Recurrent laryngeal papillomatosis".…”