Pápulas, vesículas y ampollas en paciente con leucemia linfática crónica

Eosinophilic Panniculitis and Insect Bite‐Like Eruption in a Patient with Chronic Lymphocytic Leukaemia: A Spectrum of the Same Entity

“…Cutaneous findings are relatively common in patients with hematologic disorders [ 3 – 6 ]. In 1965, Weed described a peculiar cutaneous eruption in haematological patients and termed it “exaggerated delayed hypersensitivity to mosquito bites in CLL”.…”

“…He demonstrated positive results in an intradermal test made with mosquito antigen and considered that these patients had an abnormal response to insect bites [ 7 ]. Since then, this disorder has been reported in the literature with different names, such as “insect bite-like reaction in hematologic neoplasm” [ 3 , 8 , 9 ]. However, most of these reports had not history, clinical picture, nor response to treatment or preventive measures suggestive of insect bite [ 5 – 8 , 10 ], and terms like “eosinophilic dermatosis of myeloproliferative diseases” or “eosinophilic eruption of haematoproliferative diseases” were proposed [ 4 , 9 ].…”

“…Systemic steroids are effective in suppressing eruptions, but lesions often recur when the dose is reduced. Chemotherapy regimens may also improve the lesions in some patients, but this is probably due to the fact that steroids are included in the regimen used [ 3 , 8 ]. Dapsone and phototherapy can also prevent recurrences but cutaneous manifestations only disappear when the hematologic disease is controlled.…”