Par-4-mediated recruitment of Amida to the actin cytoskeleton leads to the induction of apoptosis

Boosen, Meike; Vetterkind, Susanne; Koplin, Ansgar; Illenberger, Susanne; Preuß, Ute

doi:10.1016/j.yexcr.2005.09.010

Cited by 22 publications

(23 citation statements)

References 57 publications

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“…Similar to the findings with ectopic Par-4, endogenous Par-4 confers apoptosis by a mechanism that requires PKA phosphorylation of its T155 residue as well as nuclear translocation for inhibition of NF-nB transcription activity (18). Par-4 action may be also mediated by interactions via its leucine zipper domain with partner proteins, such as~protein kinase C (19) or Amida (20) in the cytoplasm and WT1 (21), THAP (22), or ZIPK/Daax (23) in the nucleus. Endogenous Par-4, however, is phosphorylated and inactivated by AKT and sequestered by 14-3-3 in the cytoplasm (24), thereby explaining why cancer cells survive in the presence of endogenous Par-4.…”

Section: Introductionmentioning

confidence: 57%

Par-4-Dependent Apoptosis by the Dietary Compound Withaferin A in Prostate Cancer Cells

Srinivasan¹,

Ranga²,

et al. 2007

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Section: Introductionmentioning

confidence: 57%

Par-4-Dependent Apoptosis by the Dietary Compound Withaferin A in Prostate Cancer Cells

Srinivasan¹,

Ranga²,

et al. 2007

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“…Unc-5 homolog B is a netrin receptor that plays a role in morphogenesis of the vascular system (Lu et al 2004) and oligodendrocyte precursor motility (Jarjour et al 2003). PAWR is a pro-apoptotic protein containing a leucine zipper and death domain, and is important for cell sensitization to apoptotic stimuli (Boosen et al 2005). Transforming growth factor (TGF)b3 is a growth factor that is a growth inhibitor and present in the testis and involved in spermatogenesis (Jarjour et al 2003, Lui et al 2003.…”

Section: Discussionmentioning

confidence: 99%

Regulation of the gonadal transcriptome during sex determination and testis morphogenesis: comparative candidate genes

Clement

Anway²,

Uzumcu³

et al. 2007

Reproduction

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Gene expression profiles during sex determination and gonadal differentiation were investigated to identify new potential regulatory factors. Embryonic day 13 (E13), E14, and E16 rat testes and ovaries were used for microarray analysis, as well as E13 testis organ cultures that undergo testis morphogenesis and develop seminiferous cords in vitro. A list of 109 genes resulted from a selective analysis for genes present in male gonadal development and with a 1.5-fold change in expression between E13 and E16. Characterization of these 109 genes potentially important for testis development revealed that cytoskeletal-associated proteins, extracellular matrix factors, and signaling factors were highly represented. Throughout the developmental period (E13-E16), sexenriched transcripts were more prevalent in the male with 34 of the 109 genes having testis-enriched expression during sex determination. In ovaries, the total number of transcripts with a 1.5-fold change in expression between E13 and E16 was similar to the testis, but none of those genes were both ovary enriched and regulated during the developmental period. Genes conserved in sex determination were identified by comparing changing transcripts in the rat analysis herein, to transcripts altered in previously published mouse studies of gonadal sex determination. A comparison of changing mouse and rat transcripts identified 43 genes with species conservation in sex determination and testis development. Profiles of gene expression during E13-E16 rat testis and ovary development are presented and candidate genes for involvement in sex determination and testis differentiation are identified. Analysis of cellular pathways did not reveal any specific pathways involving multiple candidate genes. However, the genes and gene network identified influence numerous cellular processes with cellular differentiation, proliferation, focal contact, RNA localization, and development being predominant. Reproduction (2007) 134 455-472

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“…FB1 is a novel protein with no strong homology with known proteins [10] and is present in the nucleus predominantly [15]. Rat FB1, called Amida, causes both apoptosis and cell cycle arrest in COS-7 cells [12,13].…”

Section: Discussionmentioning

confidence: 99%

“…Rat FB1, called Amida, causes both apoptosis and cell cycle arrest in COS-7 cells [12,13]. Since Aimda is involved in the apoptosis induced by Par-4, which was reported to play a role in prostate cancer apoptosis [15], FB1 has potential to modulate the sensitivity of prostate cancer cells to apoptotic agents. However, FB1 had little effect on the apoptotic activity of U19/EAF2 in different cell lines, including HeLa and prostate cancer cell line PC3 (data not shown).…”

Section: Discussionmentioning

confidence: 99%

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FB1, an E2A fusion partner in childhood leukemia, interacts with U19/EAF2 and inhibits its transcriptional activity

Jiang¹,

Ai²,

Xiao³

et al. 2007

Cancer Letters

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Background: U19/EAF2 is a potential tumor suppressor exhibiting frequent down-regulation and allelic loss in advanced human prostate cancer specimens. U19/EAF2 has also been identified as ELL-associated factor 2 (EAF2) based on its binding to ELL, a fusion partner of MLL in acute myeloid leukemia. U19/EAF2 is a putative transcription factor with a transactivation domain and capability of sequence-specific DNA binding.Methods: Yeast-two-hybrid-screening was used to identify U19/EAF2-binding partners. Co-immunoprecipitation and mammalian 1-hybrid assay were used to characterize a U19/EAF2-binding partner.Results: FB1, an E2A fusion partner in childhood leukemia, was identified as a binding-partner of U19/EAF2. FB1 also binds to EAF1, the only homologue of U19/EAF2. FB1 also interacts and co-localizes with ELL in the nucleus. Interestingly, FB1 inhibited the transcriptional activity of U19/EAF2 but not EAF1.Conclusions: FB1 is an important binding partner and a functional regulator of U19/EAF2, EAF1, and/or ELL.

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Par-4-mediated recruitment of Amida to the actin cytoskeleton leads to the induction of apoptosis

Cited by 22 publications

References 57 publications

Par-4-Dependent Apoptosis by the Dietary Compound Withaferin A in Prostate Cancer Cells

Par-4-Dependent Apoptosis by the Dietary Compound Withaferin A in Prostate Cancer Cells

Regulation of the gonadal transcriptome during sex determination and testis morphogenesis: comparative candidate genes

FB1, an E2A fusion partner in childhood leukemia, interacts with U19/EAF2 and inhibits its transcriptional activity

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