Parabens and Their Relation to Obesity

Kolátorová, Lucie; Šrámková, Monika; Vítků, Jana; Včelák, Josef; Lischkova, Olga; Stárka, L; Dušková, Michaela

doi:10.33549/physiolres.934004

Cited by 52 publications

(25 citation statements)

References 29 publications

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“…The direct and inverse associations between parabens and adiposity-related traits which we observed in this study did not reach significance. A recent study by Kolatorova et al showed higher concentrations of MeP and PrP in serum of obese compared to normal-weight individuals 65 , supporting the findings in a large Korean cohort 66 . Yet, a large cross-sectional study including 4,730 adults from NHANES found inverse associations between parabens and adiposity 36 .…”

Section: Discussionmentioning

confidence: 52%

Exposure to Endocrine Disrupting Chemicals in the Dutch general population is associated with adiposity-related traits

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Faassen

Beek

et al. 2020

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endocrine Disrupting chemicals (eDcs) have been linked to a variety of cardiometabolic diseases. Yet, few studies have investigated the exposure to eDcs and cardiometabolic health taking lifestyle into account. We aimed to assess exposure to five parabens, three bisphenols and thirteen metabolites of in total eight phthalates in a general Dutch population and to investigate their association with cardiometabolic traits. In 662 adult subjects from the population-based Lifelines cohort, 21 EDC analytes were measured in 24-hour urine collected in 2012, using LC-MS/MS. Association analyses between cardiometabolic traits and eDc concentrations were performed using multivariate linear models adjusting for age, sex, education, smoking, diabetes, physical activity and caloric intake. Quartile analyses were performed to assess linearity. Bisphenol A, four parabens and eight phthalate metabolites were detected in 84-100% of the samples. Adjusted associations for MiBP and MBzP and adiposity-related traits were robust for multiple testing (Beta's, BMI: 1.12, 2.52; waist circumference: 0.64, 1.56, respectively; FDR < 0.009). Associations for triglyceride, HDL-cholesterol, glucose and blood pressure were not. Linearity was confirmed for significant associations. Exposure to EDCs in the Dutch population is ubiquitous. We found direct associations between phthalates and adiposity-related traits. Prospective studies are needed to confirm these findings. During the past decades, cardiovascular diseases (CVD) and type 2 diabetes (T2D) have risen to epidemic proportions 1,2. These diseases are responsible for severe complications including myocardial infarction, stroke, blindness, lower limb amputation and renal failure, and are strongly correlated with a collection of asymptomatic cardiometabolic abnormalities such as (central) obesity, impaired glucose tolerance, elevated triglycerides, a low HDL-cholesterol, and hypertension 3,4. A combination of at least three of the above stated cardiovascular abnormalities defines the metabolic syndrome (MetS) 1. Risk factors include a combination of genetic predisposition and lifestyle (e.g. lack of physical activity, imbalanced diet). Meanwhile, a wide variety of synthetic chemicals have been introduced in our environment, some of which have been shown to cause metabolic disruptions in animal and human studies 5. Endocrine Disrupting Chemicals (EDCs) such as parabens, phenols and phthalates have been shown to be associated with the MetS 6,7 , obesity 8,9 and T2D 10,11. These EDCs have in common that they are widely used as preservatives and plasticizers and can therefore be found in a wide variety of consumer products. Exposure occurs through ingestion, inhalation, and dermal contact 12,13. Although parabens, phenols and phthalates have in common that they are metabolized and excreted fairly quickly (i.e. half-lives <24 h) and therefore are considered non-persistent 14-16 , exposure is ubiquitous throughout life and reported to be global 17-20. However, to date little is known about exposure...

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Section: Discussionmentioning

confidence: 52%

Exposure to Endocrine Disrupting Chemicals in the Dutch general population is associated with adiposity-related traits

Meer

Faassen

Beek

et al. 2020

Sci Rep

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“…Previous studies examining prenatal paraben exposure have reported inconsistent associations with fetal growth, with varying estimated directions and magnitude of effect (24)(25)(26)(64)(65)(66). More broadly, however, parabens are suspected to have effects on body composition and altered weight (67)(68)(69)(70)(71). For example, a study in the National Health and Nutrition Examination Survey (NHANES) reported that higher urinary parabens were associated with lower BMI in both children and adults (69).…”

Section: Discussionmentioning

confidence: 99%

Prenatal exposure to consumer product chemical mixtures and size for gestational age at delivery

Bommarito

Welch

Keil

et al. 2021

Preprint

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Background: While fetal growth is a tightly regulated process, it is sensitive to environmental exposures that occur during pregnancy. Many commonly used consumer products contain chemicals that can disturb processes underlying fetal growth. However, mixtures of these chemicals have been minimally examined. We investigated associations between prenatal exposure to 33 consumer product chemicals (nine organophosphate ester flame retardant [OPE] metabolites, 12 phthalate metabolites, and 12 phenols) and the odds of small- or large-for-gestational age (SGA and LGA) births.Methods: This case-control study was comprised of SGA (N = 31), LGA (N = 28), and appropriate for gestational age control (N = 31) births selected from the larger LIFECODES cohort. Biomarkers of exposure to consumer product chemicals were quantified in maternal urine collected from up to three study visits during pregnancy. In a single-pollutant approach, odds ratios (OR) and 95% confidence intervals (CI) of SGA and LGA associated with an interquartile range (IQR)-increase in exposure biomarkers were estimated using multinomial logistic regression. In a multi-pollutant approach, quantile g-computation was used to jointly estimate the OR (95% CI) of SGA and LGA per simultaneous one quartile-change in all biomarkers belonging to each chemical class. Results: Among the 33 biomarkers analyzed, 20 were detected in at least 50% of the participants. After adjusting for potential confounders, we observed reduced odds of LGA in association with higher urinary concentrations of several exposure biomarkers. For example, an IQR-increase in the OPE metabolite, diphenyl phosphate, was associated with lower odds of LGA births (OR: 0.40 [95% CI: 0.18, 0.87]). Using quantile g-computation, we estimated lower odds of an LGA birth for higher OPE metabolite concentrations (OR: 0.49 [95% CI: 0.27, 0.89]) and phthalate metabolite concentrations (OR: 0.23 [95% CI: 0.07, 0.73]). Associations between consumer product chemicals and SGA were largely null. Conclusions: Joint exposure to OPEs and phthalates was associated with lower odds of delivering LGA. Associations with LGA could indicate a specific impact of these exposures on the high end of the birth weight spectrum. Future work to understand this nuance in the associations between consumer product chemical mixtures and fetal growth is warranted.

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“…Previous studies examining prenatal paraben exposure have reported inconsistent associations with fetal growth, with varying estimated directions and magnitude of effect (19)(20)(21)(54)(55)(56). More broadly, however, parabens are suspected to have effects on body composition and altered weight (57)(58)(59)(60)(61). For example, a study in the National Health and Nutrition Examination Survey (NHANES) reported that higher urinary parabens were associated with lower BMI in both children and adults (59).…”

Section: Discussionmentioning

confidence: 99%

Prenatal exposure to consumer product chemical mixtures and size for gestational age at delivery

Bommarito

Welch

Keil

et al. 2020

Preprint

View full text Add to dashboard Cite

Background While fetal growth is a tightly regulated process, it is sensitive to environmental exposures that occur during pregnancy. Many commonly used consumer products contain chemicals that can disturb processes underlying fetal growth. However, mixtures of these chemicals have been minimally examined. We investigated associations between prenatal exposure to 33 consumer product chemicals (nine organophosphate ester flame retardant [OPE] metabolites, 12 phthalate metabolites, and 12 phenols) and the odds of small- or large-for-gestational age (SGA and LGA) births. Methods This case-control study was comprised of SGA (N = 31), LGA (N = 28), and appropriate for gestational age control (N = 31) births selected from the larger LIFECODES cohort. Biomarkers of exposure to consumer product chemicals were quantified in maternal urine collected from up to three study visits during pregnancy. In a single-pollutant approach, odds ratios (OR) and 95% confidence intervals (CI) of SGA and LGA associated with an interquartile range (IQR)-increase in exposure biomarkers were estimated using multinomial logistic regression. In a multi-pollutant approach, quantile g-computation was used to jointly estimate the OR (95% CI) of SGA and LGA per simultaneous one quartile-change in all biomarkers belonging to each chemical class. Results Among the 33 biomarkers analyzed, 20 were detected in at least 50% of the participants. After adjusting for potential confounders, we observed reduced odds of LGA in association with higher urinary concentrations of several exposure biomarkers. For example, an IQR-increase in the OPE metabolite, diphenyl phosphate, was associated with lower odds of LGA births (OR: 0.40 [95% CI: 0.18, 0.87]). Using quantile g-computation, we estimated lower odds of an LGA birth for lower OPE metabolites (OR: 0.49 [95% CI: 0.27, 0.89]) and phthalate metabolites (OR: 0.23 [95% CI: 0.07, 0.73]). Associations between consumer product chemicals and SGA were largely null. Conclusions Joint exposure to OPEs and phthalates was associated with lower odds of delivering LGA. Associations with LGA could indicate a specific impact of these exposures on the high end of the birth weight spectrum. Future work to understand this nuance in the associations between consumer product chemical mixtures and fetal growth is warranted.

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Parabens and Their Relation to Obesity

Cited by 52 publications

References 29 publications

Exposure to Endocrine Disrupting Chemicals in the Dutch general population is associated with adiposity-related traits

Exposure to Endocrine Disrupting Chemicals in the Dutch general population is associated with adiposity-related traits

Prenatal exposure to consumer product chemical mixtures and size for gestational age at delivery

Prenatal exposure to consumer product chemical mixtures and size for gestational age at delivery

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