Parabens preferentially accumulate in metastatic breast tumors compared to benign breast tumors and the association of breast cancer risk factors with paraben accumulation

Downs, Craig A.; Amin, Mohammad Mehdi; Tabatabaeian, Maryam; Chavoshani, Afsane; Amjadi, Elham; Afshari, Alireza; Kelishadi, Roya

doi:10.1016/j.envadv.2022.100325

Cited by 10 publications

(3 citation statements)

References 147 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Parabens, such as methylparaben (MeP), ethylparaben (EtP), propylparaben (PrP), and butylparaben (BuP), are a group of alkyl esters of the para-hydroxybenzoic acid esters [ 171 ] that can mimic estrogen in the body [ 172 ]. These chemicals are used as broad-spectrum antimicrobial preservatives in lotions/creams, skin foundation, eye makeup products, deodorants/perfumes, hair care products, shaving products, toothpastes, shampoos/conditioners, pharmaceuticals, textiles, clothes, and processed foods [ 173 , 174 ]. Parabens are absorbed by the dermal route or ingested and are systematically distributed and metabolized, being detected in human normal and tumoral tissues [ 175 ], hair [ 176 ], blood [ 171 ], saliva [ 177 ], breast milk [ 178 , 179 ], placenta [ 180 ], and urine [ 181 ].…”

Section: Exposure To Endocrine-disrupting Chemicals (Edcs)mentioning

confidence: 99%

“…Parabens are absorbed by the dermal route or ingested and are systematically distributed and metabolized, being detected in human normal and tumoral tissues [ 175 ], hair [ 176 ], blood [ 171 ], saliva [ 177 ], breast milk [ 178 , 179 ], placenta [ 180 ], and urine [ 181 ]. Parabens can be found intact in the human breast [ 175 ] and preferentially accumulate in metastatic breast tumors compared to benign breast tumors [ 174 ]. Tapia et al (2023) reported altered ER target gene expression and cell viability that was paraben- and cell line-specific [ 172 ].…”

Section: Exposure To Endocrine-disrupting Chemicals (Edcs)mentioning

confidence: 99%

See 1 more Smart Citation

Breast Cancer Exposomics

Neagu,

Jayaweera,

Corrice

et al. 2024

Life

View full text Add to dashboard Cite

We are exposed to a mixture of environmental man-made and natural xenobiotics. We experience a wide spectrum of environmental exposure in our lifetime, including the effects of xenobiotics on gametogenesis and gametes that undergo fertilization as the starting point of individual development and, moreover, in utero exposure, which can itself cause the first somatic or germline mutation necessary for breast cancer (BC) initiation. Most xenobiotics are metabolized or/and bioaccumulate and biomagnify in our tissues and cells, including breast tissues, so the xenobiotic metabolism plays an important role in BC initiation and progression. Many considerations necessitate a more valuable explanation regarding the molecular mechanisms of action of xenobiotics which act as genotoxic and epigenetic carcinogens. Thus, exposomics and the exposome concept are based on the diversity and range of exposures to physical factors, synthetic chemicals, dietary components, and psychosocial stressors, as well as their associated biologic processes and molecular pathways. Existing evidence for BC risk (BCR) suggests that food-borne chemical carcinogens, air pollution, ionizing radiation, and socioeconomic status are closely related to breast carcinogenesis. The aim of this review was to depict the dynamics and kinetics of several xenobiotics involved in BC development, emphasizing the role of new omics fields related to BC exposomics, such as environmental toxicogenomics, epigenomics and interactomics, metagenomics, nutrigenomics, nutriproteomics, and nutrimiRomics. We are mainly focused on food and nutrition, as well as endocrine-disrupting chemicals (EDCs), involved in BC development. Overall, cell and tissue accumulation and xenobiotic metabolism or biotransformation can lead to modifications in breast tissue composition and breast cell morphology, DNA damage and genomic instability, epimutations, RNA-mediated and extracellular vesicle effects, aberrant blood methylation, stimulation of epithelial–mesenchymal transition (EMT), disruption of cell–cell junctions, reorganization of the actin cytoskeleton, metabolic reprogramming, and overexpression of mesenchymal genes. Moreover, the metabolism of xenobiotics into BC cells impacts almost all known carcinogenic pathways. Conversely, in our food, there are many bioactive compounds with anti-cancer potential, exerting pro-apoptotic roles, inhibiting cell cycle progression and proliferation, migration, invasion, DNA damage, and cell stress conditions. We can conclude that exposomics has a high potential to demonstrate how environmental exposure to xenobiotics acts as a double-edged sword, promoting or suppressing tumorigenesis in BC.

show abstract

Section: Exposure To Endocrine-disrupting Chemicals (Edcs)mentioning

confidence: 99%

Section: Exposure To Endocrine-disrupting Chemicals (Edcs)mentioning

confidence: 99%

Breast Cancer Exposomics

Neagu,

Jayaweera,

Corrice

et al. 2024

Life

View full text Add to dashboard Cite

show abstract

“…However, there is controversy about the safety of p-hydroxybenzoic acid in human health, as there is no evidence of its toxicity in humans [ 138 ]. In this sense, Downs et al (2023) [ 139 ] evaluated the relation between accumulation of p-hydroxybenzoic acid and methyl, ethyl, propyl, and butyl esters and the incidence of both malignant and benign breast tumors in patients. The authors concluded that propyl and butyl paraben concentrations are higher on metastatic tissue compared to non-metastatic breast cancer tissue.…”

Section: Phytochemistrymentioning

confidence: 99%

Ethnobotany, Biological Activities and Phytochemical Compounds of Some Species of the Genus Eryngium (Apiaceae), from the Central-Western Region of Mexico

et al. 2023

View full text Add to dashboard Cite

There are approximately 250 species of Eryngium L. distributed throughout the world, with North America and South America being centers of diversity on this continent. In the central-western region of Mexico there may be around 28 species of this genus. Some Eryngium species are cultivated as leafy vegetables, ornamental, and medicinal plants. In traditional medicine they are used to treat respiratory and gastrointestinal conditions, diabetes, and dyslipidemia, among others. This review addresses the phytochemistry and biological activities, as well as traditional uses, distribution, and characteristics of the eight species of Eryngium reported as medicinal in the central-western region of Mexico: E. cymosum, E. longifolium, E. fluitans (or mexicanum), E. beecheyanum, E. carlinae, E. comosum, E. heterophyllum, and E. nasturtiifolium. The extracts of the different Eryngium spp. have shown biological activities such as hypoglycemic, hypocholesterolemic, renoprotective, anti-inflammatory, antibacterial, and antioxidant, among others. E. carlinae is the most studied species, and phytochemical analyses, performed mainly by high-performance liquid chromatography (HPLC) and gas chromatography coupled with mass spectrometry (GC-MS), have shown its content of terpenoids, fatty acids, organic acids, phenolic acids, flavonoids, sterols, saccharides, polyalcohols, and aromatic and aliphatic aldehydes. According to the results of this review on Eryngium spp., they constitute a relevant alternative as a source of bioactive compounds for pharmaceutical, food, and other industries. However, there is a lot of research to be conducted regarding phytochemistry, biological activities, cultivation, and propagation, in those species with few or no reports.

show abstract