Parabrachial complex glutamate receptors modulate the cardiorespiratory response evoked from hypothalamic defense area

Díaz-Casares, Amelia; López-González, Manuel Víctor; Peinado-Aragonés, Carlos Antonio; González-Barón, S; Dawid-Milner, Marc Stefan

doi:10.1016/j.autneu.2012.06.001

Cited by 17 publications

(23 citation statements)

References 46 publications

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“…Electrical stimulation allowed us to regulate tightly the onset and offset of HDA activation. We selected the most usual stimulation parameters used in previous studies (Lara et al 1994, 2002; Dawid‐Milner et al 1995, 2001, 2003; Silva‐Carvalho et al 1995 b ; Díaz‐Casares et al 2009, 2012).…”

Section: Discussionmentioning

confidence: 99%

“…In previous studies, we have demonstrated a role of the parabrachial complex in the cardiorespiratory response evoked on electrical stimulation of the HDA (Díaz‐Casares et al 2009, 2012). We have also demonstrated the participation of the A5 region in the cardiorespiratory responses evoked on parabrachial electrical and chemical stimulation (Dawid Milner et al 2003).…”

Section: Introductionmentioning

confidence: 98%

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Neurons of the A5 region are required for the tachycardia evoked by electrical stimulation of the hypothalamic defence area in anaesthetized rats

López-González¹,

Díaz-Casares²,

Peinado-Aragonés³

et al. 2013

Experimental Physiology

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New Findings r What is the central question of this study?As the parabrachial complex plays a role in the cardiorespiratory response evoked from the hypothalamic defence area (pressor response and tachycardia) and the A5 region is involved in the responses evoked from the parabrachial complex, a possible interaction between the hypothalamic defence area and A5 is suggested. Accordingly, the present study was carried out to assess this hypothesis in rats. r What is the main finding and its importance?The neuromorphological, neuropharmacological and electrophysiological results of our study demonstrate, for the first time, that the A5 region is an important component of those brainstem pathways known to be involved in mediating the autonomic changes associated with the electrically evoked defence response. In order to assess the possible interactions between the pontine A5 region and the hypothalamic defence area (HDA), we have examined the pattern of double staining for c-Fos protein immunoreactivity (c-Fos-ir) and tyrosine hydroxylase, throughout the rostrocaudal extent of the A5 region in spontaneously breathing anaesthetized male Sprague-Dawley rats during electrical stimulation of the HDA. Activation of the HDA elicited a selective increase in c-Fos-ir with an ipsilateral predominance in catecholaminergic and non-catecholaminergic A5 somata (P < 0.001 in both cases). A second group of experiments was done to examine the importance of the A5 region in modulating the cardiorespiratory response evoked from the HDA. Cardiorespiratory changes were analysed in response to electrical stimulation of the HDA before and after ipsilateral microinjection of muscimol within the A5 region. Stimulation of the HDA evoked an inspiratory facilitatory response, consisting of an increase in respiratory rate (P < 0.001) due to a decrease in expiratory time (P < 0.01). The respiratory response was accompanied by a pressor response (P < 0.001) and tachycardia (P < 0.001). After muscimol microinjection within the A5 region, pressor and heart rate responses to HDA stimulation were reduced (P < 0.01 and P < 0.001, respectively). The respiratory response persisted unchanged. Finally, to confirm functional interactions between the HDA and the A5 region, extracellular recordings of putative A5 neurones were obtained during HDA stimulation. Seventy-five A5 cells were recorded, 35 of which were affected by the HDA (47%). These results indicate that

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 98%

Neurons of the A5 region are required for the tachycardia evoked by electrical stimulation of the hypothalamic defence area in anaesthetized rats

López-González¹,

Díaz-Casares²,

Peinado-Aragonés³

et al. 2013

Experimental Physiology

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“…Kynurenic acid, a nonspecific ionotropic glutamate receptor antagonist, microinjected into the lPB and mPB abolishes the tachycardia and decreased the pressor response to HDA electrical stimulation (Figure 5A and B). The respiratory response is only abolished when kynurenic acid is microinjected into the lPB ( Figure 5A) [116]. These results suggest that ionotropic glutamate receptors located within the lPB region are involved in both the respiratory-and the cardiovascular-evoked responses from the HDA, whereas ionotropic glutamate receptors located in mPB seem to be only involved in the modulation of the cardiovascular response.…”

Section: Dorsolateral Pons In Cardiorespiratory Hypothalamic Defense mentioning

confidence: 80%

“…Studies related to glutamate receptors suggest that this neurotransmitter plays a crucial role in mediating the functional relation between the PBc and the HDA [116]. Glutamate activates metabotropic and ionotropic (NMDA and non-NMDA) receptors [117].…”

Section: Dorsolateral Pons In Cardiorespiratory Hypothalamic Defense mentioning

confidence: 99%

“…The pattern of the cardiorespiratory response evoked from HDA is modified by the microinjection of different glutamate antagonists into the PBc [116]. Kynurenic acid, a nonspecific ionotropic glutamate receptor antagonist, microinjected into the lPB and mPB abolishes the tachycardia and decreased the pressor response to HDA electrical stimulation (Figure 5A and B).…”

Section: Dorsolateral Pons In Cardiorespiratory Hypothalamic Defense mentioning

confidence: 99%

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Role of the Dorso- and Ventrolateral Pons in Cardiorespiratory Hypothalamic Defense Responses

Díaz-Casares¹,

López-González²,

Dawid-Milner³

2018

Hypothalamus in Health and Diseases

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Stimulation of discrete sites throughout the hypothalamus elicits autonomic and somatic responses. This chapter will stand out the cardiorespiratory changes evoked from stimulation of specific areas within the caudal hypothalamus: the perifornical area and the dorsomedial nucleus. The stimulation of these regions, known as the hypothalamic defense area (HDA), produces a pattern of visceral and somatic changes characteristic of the defense reaction, which includes tachypnea, tachycardia and a pressor response. A close review of the literature demonstrates that the changes observed during this defensive behavioral response are partially mediated by the interactions with pontine regions. These include the parabrachial complex, located in the dorsolateral pons, and the A5 region, located in the ventrolateral pons. Specific glutamatergic stimulation of cell bodies located within the parabrachial complex and A5 region evokes cardiorespiratory responses similar to those observed during stimulation of the HDA. This functional interaction suggests a possible role of glutamate pontine receptors in the modulation of the HDA response. This chapter describes the most important evidences confirming the implication of the dorso-and ventrolateral pons in the control of cardiorespiratory autonomic responses evoked from the perifornical and dorsomedial hypothalamus and the role of glutamate in this interaction.

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Brainstem and Autonomic Nervous System Dysfunction: A Neurosurgical Point of View

Martín-Gallego

González-García

Carrasco-Brenes

et al. 2017

Acta Neurochirurgica Supplement

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Central autonomic control nuclei and pathways are mainly integrated within the brainstem, especially in the medulla oblongata. Lesions within these structures can lead to central dysautonomia.Central autonomic control structures can be damaged by tumors, during surgery, or by other neurosurgical pathologies. These may elicit clinical or subclinical autonomic complications that can constitute a serious clinical problem.The authors present a broad review of the central autonomic nervous system, its possible dysfunctions, and the relation between neurosurgery and this "not-well-known system". Preliminary results of an autonomic study of brainstem lesions that is currently being carried out by the authors are also shown.

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Parabrachial complex glutamate receptors modulate the cardiorespiratory response evoked from hypothalamic defense area

Cited by 17 publications

References 46 publications

Neurons of the A5 region are required for the tachycardia evoked by electrical stimulation of the hypothalamic defence area in anaesthetized rats

Neurons of the A5 region are required for the tachycardia evoked by electrical stimulation of the hypothalamic defence area in anaesthetized rats

Role of the Dorso- and Ventrolateral Pons in Cardiorespiratory Hypothalamic Defense Responses

Brainstem and Autonomic Nervous System Dysfunction: A Neurosurgical Point of View

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