Parabrachial neurons promote nociplastic pain

Palmiter, Richard D.

doi:10.1016/j.tins.2024.07.002

Trends in Neurosciences

2024

DOI: 10.1016/j.tins.2024.07.002

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Parabrachial neurons promote nociplastic pain

Richard D. Palmiter

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2024

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Cited by 3 publications

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Lateral parabrachial nucleus: the commander-in-chief for nocifensive behavior expression in cold allodynia

Hor,

Duan

2024

Pain

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Lateral parabrachial nucleus: the commander-in-chief for nocifensive behavior expression in cold allodynia

Hor,

Duan

2024

Pain

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Involvement of the parabrachial nucleus in emergence from general anesthesia

Li,

Zhu,

Xiang

et al. 2024

Front. Neurosci.

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The parabrachial nucleus (PBN), located in the dorsolateral pons, is involved in many important biological functions, such as sensory signaling, feeding, defensive behaviors, fear, anxiety, and sleep–wake cycles. General anesthesia shares the classical feature of reversible loss of consciousness with natural sleep, and accumulating evidence has indicated that general anesthesia and sleep–wake behaviors share some common underlying neural mechanism. In recent years, emerging studies have investigated the involvement of PBN in emergence from general anesthesia, but divergence exists in terms of different types of general anesthetics or different durations of treatment with the same group of general anesthetics. Here, we reviewed the current literature and summarized the evidence about the contribution of PBN to general anesthesia.

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A perspective: neuraxial therapeutics in pain management: now and future

DeAndres,

Dickenson,

Hayek

et al. 2024

Front. Pain Res.

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The neuraxial delivery of drugs for the management of pain and other spinal pathologies is widely employed and is the subject of a large volume of ongoing research with several thousand papers appearing in the past 5 years alone on neuraxial delivery. Several learned texts have been recently published. A number of considerations have contributed to this widespread interest in the development of the use of neuraxial therapeutics to manage pain. In the following section, major topics relevant to spinal encoding and in the use of neuraxial therapeutics are considered by the Frontiers in Pain Research editors of the research topic: “Neuraxial Therapeutics in Pain Management: Now and Future”. This paper seeks to serve as a perspective to encourage the submission of manuscripts reflecting research in this exciting area.

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Parabrachial neurons promote nociplastic pain

Cited by 3 publications

References 120 publications

Lateral parabrachial nucleus: the commander-in-chief for nocifensive behavior expression in cold allodynia

Lateral parabrachial nucleus: the commander-in-chief for nocifensive behavior expression in cold allodynia

Involvement of the parabrachial nucleus in emergence from general anesthesia

A perspective: neuraxial therapeutics in pain management: now and future

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