Paracetamol misusing to dental pain: a case-report and recommandations for treatment

Abstract

Introduction: The paracetamol is the most widely used painkiller to dental pain. Patients self-medicating with paracetamol for dental pain had 12.8 more times lead to overdose than patients with other pains. The aim of this work was to propose a standardized management in case of paracetamol overdose from a clinical case report. Observation: A 56-year-old man was referred to the General Emergency Department because he had ingested 32 grams of paracetamol in less than 24 hours due to a dental pain. He was in a state of haemodynamic and hypothermic shock. He was placed on the liver transplant list due to fulminant hepatitis. The dental check-up found juxta-pulpal carious lesions on the four wisdom teeth which were removed before the transplantation. Conclusion: Paracetamol overdose is one of the leading causes of liver failure. The estimated toxic dose was 150 mg/kg/day or about 10 g/day. N-acetylcysteine treatment should be leaded early, between 8 and 10 hours after ingestion. The paracetamol-aminotransferase, as a risk prediction tool, reproductibles methods and biomarkers can identify overdoses and lead to a faster medical care. Information campaigns and warning articles on overdosing risk must be continued to strengthen the prevention message for the population.

Characterization and biodegradation of paracetamol by biomass of Bacillus licheniformis strain PPY-2 isolated from wastewater

“…It is among the top ten drugs consumed by countries worldwide. In 2016, the United States consumed around 49-kilo metric tons, followed by China in the second place with 34.6-kilo metric tons and Europe with 48.4-kilo metric tons (Debortoli et al 2021 ). APAP actively treats a wide range of symptoms such as flu, cough, cold, fever, allergy, pain, and sleep disorders; therefore, during the Coronavirus disease-2019 (COVID-19) disaster, this molecule was included as a significant component of the therapeutic plans and was widely consumed globally (Poddar et al 2022 ).…”