Paracetamol Versus Ondansetron for Prevention of Postoperative Shivering in Liposuction Surgeries Under Combined General Epidural Anaesthesia: A Randomized Controlled Trial

Efficacy of intravenous acetaminophen on postoperative shivering: A meta-analysis of randomized controlled trials

“…A low risk of the overall risk of bias for included 9 trials. [11–18] All 9 included trials provided a detailed description of randomization. The Cochrane Handbook for Systematic Reviews of Interventions was used to evaluate the risk of bias of the RCTs.…”

“…The Cochrane Handbook for Systematic Reviews of Interventions was used to evaluate the risk of bias of the RCTs. Eight studies [11,13–18] were double-blinded. Four trials [11,13,17] reported allocation concealment.…”

“…Eight studies [11,13–18] were double-blinded. Four trials [11,13,17] reported allocation concealment. Most of the studies reviewed lacked sufficient details in allocation concealment, in such cases, we were conservative in our risk of bias evaluation by tending to classify trials as having an “unclear risk of bias.” In addition, all studies reported the completion of the trial without withdrawals, and all the studies reported all the endpoints mentioned in the Methods section (reporting bias).…”

“…Acetaminophen versus placebo on POS: 9 trials, [11–18] the incidence of POS (pooled RR 0.43, 95% CI: 0.35–0.52) in the acetaminophen group was significantly lower than that in the control group (Fig. 3), the reduction effect in severe shivering was also very significant (Fig.…”

“…Other adverse effects: PON (postoperative nausea) or postoperative vomiting (POV): There were 3 studies in 9 trials [11,13,17] reporting PON or POV. Compared with placebo, the experimental group did not show improvement in POS compared to that in the control group, with low heterogeneity (pooled RR 1.23, 95% CI: 0.61–2.48) (Fig.…”