Paracetamol vs. Intravenous Morphine Plus Diclofenac in Renal Colic Pain: A Randomized Clinical Trial

Vahdati, Samad Shams; Robaei, Navideh; Habibollah, Paria; Jafari-Rouhi, Asghar; Mohammadi, Sahar; Piri, Reza

doi:10.5812/numonthly.77193

Cited by 2 publications

(2 citation statements)

References 30 publications

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“…showed that IV administration of the combination of 0.1 mg/kg morphine and 75 mg diclofenac had no priority than 1 gr paracetamol, in renal colic pain management. [ 22 ] Using another NSAIDs, different dose of morphine and considering morphine alone as a control group explained the different results.…”

Section: Discussionmentioning

confidence: 99%

Intravenous morphine plus ibuprofen or ketorolac versus intravenous morphine alone in reducing renal colic pain intensity in emergency department

Tavoli

Safaie

Babaniamansour

et al. 2022

Turkish Journal of Emergency Medicine

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OBJECTIVES: This study aimed to compare the efficacy of intravenous (IV) morphine plus ibuprofen or ketorolac versus IV morphine alone in controlling renal colic pain in the emergency department. METHODS: This double-blind, randomized clinical trial was conducted during November 2018 and March 2019 in Iran. Patients aged 18–65 years with acute renal colic and numerical rating scale (NRS) score of higher than 6 of 10 were enrolled to the study. They were randomly assigned to I, K, and control groups receiving 5 mg morphine with 800 mg ibuprofen ( n = 65), 5 mg morphine with 30 mg ketorolac ( n = 65), or only 5 mg morphine ( n = 65) intravenously, respectively. NRS was evaluated 0, 15, 30, 60, and 120 min after injection. RESULTS: A total of 195 participants took part in the study. The presence of stone in pelvis area was higher in I group ( P = 0.027). The mean rescue analgesic dose was higher in the control group and lower in K group ( P = 0.031). From the 15 th min, the NRS reduction in I and K group was higher than the control group ( P < 0.001), but the difference between I and K group was not statistically significant in total ( P = 1.0) or in the all follow-up time intervals (15 th P = 0.864, 30 th P = 0.493, 60 th P = 0.493, and 120 th min P = 1.0). The largest difference in pain reduction was observed in 120 th min and mean of NRS was 2.9 (95% confidence interval [CI]: 2.6–3.3), 2.9 (95% CI: 2.6–3.3) and 7.0 (95% CI: 6.7–7.4) in I, K and control group, respectively. The adverse effects showed in 18.5%, 20.0%, and 13.8% of I, K, and control group, respectively. CONCLUSION: IV ibuprofen plus morphine and IV ketorolac plus morphine had similar effects in reducing renal colic pain but were more effective than IV morphine alone.

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Section: Discussionmentioning

confidence: 99%

Intravenous morphine plus ibuprofen or ketorolac versus intravenous morphine alone in reducing renal colic pain intensity in emergency department

Tavoli

Safaie

Babaniamansour

et al. 2022

Turkish Journal of Emergency Medicine

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“…the re-emergence of alternative therapies (7,8). In early and recent discussions, there are arguments that metamizole sodium at a standard dose of 1 g fails to effect immediately (9)(10)(11).…”

mentioning

confidence: 99%

Short-Term Use Of Metamizole Sodium Versus Diclofenac Sodium In Acute Renal Colic Pain In Turkish Patients; A Double-Blind, Observational Study

Derici¹,

Ergün²

2019

Turk Hij Den Biyol Derg

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Akut renal kolik ağrısı olan Türk hastalarda kısa süreli metamizol sodyum ile diklofenak sodyum tedavilerinin karşılaştırılması; çift kör, gözlemsel bir çalışma Mehmet Kürşat DERICI 1 , Hakan ERGÜN 2 ÖZET Amaç: Renal kolik ağrısı, acil servis başvurularının en sık nedenlerinden biridir. Metamizol sodyum ve diklofenak, ilaçların bulunduğu ülkelerde en yaygın kullanılan narkotik olmayan ilaçlardır. Bu çalışmanın amacı, Ankara'daki acil servislerde akut renal kolik ağrısının tedavisinde metamizol sodyum ve diklofenak'ın etkinliğini ve güvenliğini karşılaştırmaktır. Yöntem: Renal kolik ağrısı olan 88 hasta intramüsküler metamizol sodyum (1 g) (n=48) veya diklofenak sodyum (75 mg) (n=40) ile tedavi edildi. Ağrı şiddeti, ilaç uygulanmadan önce (başlangıç düzeyi) ve uygulandıktan 30, 60, 90 ve 120 dakika sonra, Görsel Analog Skala (0-100 mm) ve 5-Nokta Sözel Derecelendirme Ölçeği ile ölçüldü. Bulgular: Her iki tedavi grubu da yaş, cinsiyet ve başlangıçtaki ağrı şiddeti yönlerinden analiz edildiğinde homojendi. Her iki tedavi de iyi tolere edildi ve gözlenen yan etkilerin hiçbiri ciddi değildi. Metamizol sodyum grubunda beş, diklofenak grubunda ise üç hasta ek tedaviye ihtiyaç duydu. Ölçülen tüm zaman noktaları için gruplar arasındaki ortalama ağrı şiddeti farkı anlamlı değildi. Her iki ilaç için de hekim ve hasta değerlendirmeleri arasında anlamlı fark yoktu.

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Paracetamol vs. Intravenous Morphine Plus Diclofenac in Renal Colic Pain: A Randomized Clinical Trial

Cited by 2 publications

References 30 publications

Intravenous morphine plus ibuprofen or ketorolac versus intravenous morphine alone in reducing renal colic pain intensity in emergency department

Intravenous morphine plus ibuprofen or ketorolac versus intravenous morphine alone in reducing renal colic pain intensity in emergency department

Short-Term Use Of Metamizole Sodium Versus Diclofenac Sodium In Acute Renal Colic Pain In Turkish Patients; A Double-Blind, Observational Study

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