Paracingulate sulcus morphology in men with early-onset schizophrenia

Provost, Jean-Bernard Le; Bartrés‐Faz, David; Paillère-Martinot, Marie-Laure; Artiges, Éric; Pappatà, Sabina; Recasens, Christophe; Pérez-Gómez, Mercedes; Bernardo, Miquel; Baeza, I.; Baylé, F.; Martinot, Jean‐Luc

doi:10.1192/bjp.182.3.228

Cited by 90 publications

(63 citation statements)

References 49 publications

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“…In contrast to the results in men, only a third of the left hemispheres of women (one study) (Yucel et al 2001) and patients with schizophrenia (two studies) (Yucel et al 2002;Le Provost et al 2003) have prominent paracingulate sulci. The Paus study found that the paracingulate sulcus was absent or prominent more often in women than men regardless of hemisphere (Paus et al 1996b).…”

Section: Introductionmentioning

confidence: 54%

Paracingulate asymmetry in anterior and midcingulate cortex: sex differences and the effect of measurement technique

et al. 2009

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Many structural brain asymmetries accompany left hemisphere language dominance. For example, the cingulate sulcus is larger in the medial cortex of the right hemisphere, while the more dorsal paracingulate sulcus is larger on the left. The functional significance of these asymmetries is unknown because fMRI studies rarely attempt to localize activation to specific sulci, possibly due to difficulties in consistent sulcal identification. In medial cortex, for example, there are many regions of partial sulcal overlap where MRI images do not provide sufficient information to unambiguously distinguish a paracingulate sulcus from a displaced anterior cingulate segment. As large samples of postmortem material are rarely available for cytoarchitectural studies of sulcal variation, we have investigated the effect of variation in boundary and sulcal definition on paracingulate asymmetry in the MRI scans of 200 healthy adults (100 men, 100 women). Although women displayed a reliable asymmetry in the size of the paracingulate sulcus, regardless of boundary definition or technique, asymmetry was greatest when (1) the measurement was limited to the midcingulate region between the genu and the anterior commissure; and (2) the more dorsal of two overlapping sulci was always classified as a paracingulate sulcus (rather than as a displaced cingulate segment). The fact that paracingulate asymmetry is maximal in the midcingulate region suggests that this region may play a particular role in hemispheric specialization for language. Future work should investigate the structural and functional correlates of sulcal variation in this region.

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Section: Introductionmentioning

confidence: 54%

Paracingulate asymmetry in anterior and midcingulate cortex: sex differences and the effect of measurement technique

et al. 2009

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“…Several schizophrenia studies have previously reported deviations in sulcus anatomy, 10,35,[62][63][64][65] consistent with the common hypothesis that schizophrenia has a developmental component. 66 The deviation detected in the junction between the STS and its anterior branch suggests an early event that may have occurred between 25 and 29 weeks of gestation.…”

Section: Sulcal Junction and Brain Maturationmentioning

confidence: 63%

"Where Do Auditory Hallucinations Come From?"--A Brain Morphometry Study of Schizophrenia Patients With Inner or Outer Space Hallucinations

Plaze

Paillère-Martinot

Penttilä

et al. 2009

Schizophrenia Bulletin

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Auditory verbal hallucinations are a cardinal symptom of schizophrenia. Bleuler and Kraepelin distinguished 2 main classes of hallucinations: hallucinations heard outside the head (outer space, or external, hallucinations) and hallucinations heard inside the head (inner space, or internal, hallucinations). This distinction has been confirmed by recent phenomenological studies that identified 3 independent dimensions in auditory hallucinations: language complexity, self-other misattribution, and spatial location. Brain imaging studies in schizophrenia patients with auditory hallucinations have already investigated language complexity and self-other misattribution, but the neural substrate of hallucination spatial location remains unknown. Magnetic resonance images of 45 right-handed patients with schizophrenia and persistent auditory hallucinations and 20 healthy right-handed subjects were acquired. Two homogeneous subgroups of patients were defined based on the hallucination spatial location: patients with only outer space hallucinations (N 5 12) and patients with only inner space hallucinations (N 5 15). Between-group differences were then assessed using 2 complementary brain morphometry approaches: voxel-based morphometry and sulcus-based morphometry. Convergent anatomical differences were detected between the patient subgroups in the right temporoparietal junction (rTPJ). In comparison to healthy subjects, opposite deviations in white matter volumes and sulcus displacements were found in patients with inner space hallucination and patients with outer space hallucination. The current results indicate that spatial location of auditory hallucinations is associated with the rTPJ anatomy, a key region of the ''where'' auditory pathway. The detected tilt in the sulcal junction suggests deviations during early brain maturation, when the superior temporal sulcus and its anterior terminal branch appear and merge.

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“…46 An asymmetric pattern, with different types in the left and right hemispheres, is common in healthy individuals. 25 On the contrary, there is a lack of such normal ACC asymmetry in patients with schizophrenia [47][48][49][50][51] and in individuals at high risk for schizophrenia. 31,[52][53][54] This observation is line with the hypothesis that anomalies of brain asymmetry are a key feature of schizophrenia.…”

Section: Discussionmentioning

confidence: 97%

Cognitive control deficit in patients with first-episode schizophrenia is associated with complex deviations of early brain development

Plaze

Oppenheim

Gaillard

et al. 2017

JPN

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Paracingulate sulcus morphology in men with early-onset schizophrenia

Abstract: Since the PCS has developed at 36 weeks of gestation, these findings suggest an impaired maturation of the cingulate region during the third trimester.

Cited by 90 publications

References 49 publications

Paracingulate asymmetry in anterior and midcingulate cortex: sex differences and the effect of measurement technique

Paracingulate asymmetry in anterior and midcingulate cortex: sex differences and the effect of measurement technique

"Where Do Auditory Hallucinations Come From?"--A Brain Morphometry Study of Schizophrenia Patients With Inner or Outer Space Hallucinations

Cognitive control deficit in patients with first-episode schizophrenia is associated with complex deviations of early brain development

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