Paracoccidioides brasiliensis in a brain abscess: First French case

Poisson, D. M.; Heitzmann, Anne; Mille, Catherine; Muckensturm, B; Dromer, Françoise; Dupont, B.; Hocqueloux, Laurent

doi:10.1016/j.mycmed.2007.02.001

Cited by 6 publications

(4 citation statements)

References 11 publications

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“…Paracoccidioidomycosis is a chronic, granulomatous, systemic mycosis caused by the P. brasiliensis fungus 2,3 . Also called Lutz-Splendore-Almeida disease or South American blastomicosis, it was described by Adolfo Lutz in 1908 pseudococcidioidal granuloma; then in 1928, Almeida and Lacaz named the Paracoccidioides genus and in 1930, Almeida called the fungus Paracoccidioides brasiliensis 1 .…”

Section: Discussionmentioning

confidence: 99%

Case report: Multifocal chronic paracoccidioidomycosis in an adult

Zapata¹,

Villanueva²,

Arrunátegui³

et al. 2024

Colomb Med

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Paracoccidioides brasiliensis is the ethiological agent of one of the most prevalent systemic mycosis in Latin America, where around ten-million individuals are affected. Brazil has the highest incidence but in Venezuela, Colombia, Ecuador, and Argentina cases have also been reported. We describe a 56-year-old male with a one year history of lip, oral mucosa, and lung lesions. Granulomas and multinucleated giant cells were observed in histopathological evaluation with haematoxilyn-eosin stain. Mycologic studies (KOH and Gomori Grocott stain) showed blastoconidias with multiple budding. Serologic tests for paracoccidioidine were reactive. A diagnosis of chronic multifocal paracoccidioidomycosis was made. Initially, amphotericin B 0.7 mg/kg per day was started for fifteen days and consecutively itraconazole (400 mg/day) was administered orally with improvement of skin and lung lesions; however, an important residual fibrosis was observed. The patient was lost to follow up. We highlight the importance of an early diagnosis and adequate treatment to decrease sequelae in patient quality of life.

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Section: Discussionmentioning

confidence: 99%

Case report: Multifocal chronic paracoccidioidomycosis in an adult

Zapata¹,

Villanueva²,

Arrunátegui³

et al. 2024

Colomb Med

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“…None of the above reports, however, mentioned attempts at isolating the fungus from the environment. Another important blocking factor in the search for the fungus's habitat is its capacity to enter prolonged quiescent stages, which has been demonstrated by the approximately 90 imported cases reported from nonendemic countries, as exemplified by the patients recently diagnosed in Europe (Buitrago et al, 2011;Mayayo et al, 2007;Poisson et al, 2007). All patients corresponded to emigrants living in Japan, the USA, Canada or several of the European countries where they had lived for a mean of 14 years after abandoning their native PCM-endemic homelands (Lacaz et al, 2002;Nucci et al, 2009;Shankar et al, 2011).…”

Section: General Concepts On Ecologymentioning

confidence: 99%

Lung Diseases - Selected State of the Art Reviews

Irusen¹

2012

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“…In addition, some of them have been reported outside of the endemic areas (Europe, Japan, USA), all cases occurring in immigrants, tourists, or workers returning from endemic countries (Buitrago et al, 2011;Poisson et al, 2007). For these reasons, it is essential that physicians around the world be informed of the clinical characteristics of these fungal diseases in order to include them in their differential diagnosis of patients coming from or visiting the recognized endemic areas.…”

Section: Introductionmentioning

confidence: 99%

“…In addition and based on high polygenetic the above reports, however, mentioned attempts at isolating the fungus from the environment. Another important blocking factor in the search for the fungus's habitat is its capacity to enter prolonged quiescent stages, which has been demonstrated by the approximately 90 imported cases reported from nonendemic countries, as exemplified by the patients recently diagnosed in Europe (Buitrago et al, 2011;Mayayo et al, 2007;Poisson et al, 2007). All patients corresponded to emigrants living in Japan, the USA, Canada or several of the European countries where they had lived for a mean of 14 years after abandoning their native PCM-endemic homelands (Lacaz et al, 2002;Nucci et al, 2009;Shankar et al, 2011).…”

Section: Introductionmentioning

confidence: 99%