Paracoccidioidomycosis: acute-subacute clinical form, juvenile type

Marques, Sílvio Alencar; Lastória, Joel Carlos; Camargo, Rubens de Figueiredo; Marques, Mariângela Esther Alencar

doi:10.1590/abd1806-4841.20164953

Cited by 5 publications

(4 citation statements)

References 7 publications

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“…Oral lesions are the most frequent clinical manifestation of chronic PCM 12 and an essential aspect of its diagnosis 3 . In this case, ulcerated lesions known as moriform stomatitis were observed on the perioral region in addition to lips vermilion and jugal mucosa as described by Marques et al 5 and Neville et al 7 . However, the definitive diagnosis of PCM required the confirmation of fungal presence in the tissues through histopathological examination 7,8,17 .…”

Section: Discussionsupporting

confidence: 63%

Oral Paracoccidioidomycosis, Clinical Characteristics, Diagnosis and Treatment

Mateus,

Couto,

Cartágenos

et al. 2023

J Oral Diag

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Paracoccidioidomycosis (PCM) is an infection caused by the dimorphic fungusParacoccidioides brasiliensis, which has a predilection for hot and humid places; thus, this disease has a particularly high incidence in Brazil. Children, adolescents, and adults can be affected by acute/subacute or chronic PCM. To describe the clinical-pathological characteristics and treatment of a case of chronic PCM oral lesion. The oral examination of a 57-year-old male patient revealed moriform stomatitis on the perioral region (irregular shape), lips vermilion, and continuity with the jugal mucosa. After an incisional biopsy, the anatomopathological analysis confirmed the diagnosis of PCM. The patient was referred to a reference center for tropical diseases and treated with 400mg sulfamethoxazole and 80mg trimethoprim twice a day. Since some adverse effects were observed, the treatment was switched to 100mg of itraconazole twice a day. The follow-up examination revealed accelerated healing of the oral lesions and reduction of the inflammatory process.Stomatologists play a key role in the identification of PCM oral lesions and referral for adequate treatment by an infectious disease specialist.

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Section: Discussionsupporting

confidence: 63%

Oral Paracoccidioidomycosis, Clinical Characteristics, Diagnosis and Treatment

Mateus,

Couto,

Cartágenos

et al. 2023

J Oral Diag

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“…Eventually it may affect individuals up to 35 years old. 6,11 It is characterized by compromising the reticuloendothelial system, generating adenomegaly and hepatosplenomegaly, and by causing osteoarticular and cutaneous lesions. 5 Lymph node involvement affects predominantly the cervical, axillary and inguinal chains, and fistulization may occur.…”

Section: A B Cmentioning

confidence: 99%

“…8 In the acute/ subacute type, mucosal lesions are rare, but papulo-erosive lesions with hemorrhagic dots (mulberry-like appearance) may be present in oral and nasal mucosa. 3,9,11 Abdominal involvement in PCM is normally seen in the subacute form, with a wide variety of clinical manifestations, including nausea, vomiting, weight loss, weakness, pruritus, jaundice, choluria, fecal acholia, ascites, abdominal pain and hepatosplenomegaly. 5,12,13 Jaundice in PCM is reported as a severe and late manifestation of the disease, which is associated with a poor prognosis.…”

Section: A B Cmentioning

confidence: 99%

Paracoccidioidomycosis in an Elderly Simulating Cholangiocarcinoma

Guerra

Simões

Valle

et al. 2021

SPDV

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Paracoccidioidomycosis, the most prevalent deep mycosis in Latin America, is caused by dimorphic species of the genus Paracoccidioides, affects predominantly male rural workers between 30-50 years of age and is an important cause of morbidity and mortality. It can present in two clinical forms: acute/subacute or chronic. In rare cases paracoccidioidomycosis may simulate neoplasia and must be considered as a differential diagnosis of intra-abdominal tumors in endemic areas. We report an exuberant case of subacute paracoccidioidomycosis in an elderly lady, although it is more frequent in the juvenile form. Multiple facial skin lesions were associated with a wasting syndrome and extensive adenopathy including in the hepatic area, causing bile duct dilatation simulating a cholangiocarcinoma. Skin histopathology was diagnostic and antifungal treatment allowed complete resolution of cutaneous and systemic lesions, thus highlighting the merit of the dermatologist, who was fundamental for the conclusive diagnosis and institution of specific therapy, resulting in a favorable outcome.

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“…O envolvimento ganglionar é predominantemente das cadeias cervical, axilar e inguinal, podendo ocorrer fistulização. 1,6 Adenomegalia abdominal pode causar dor abdominal difusa e compressão de estruturas como as vias biliares (icterícia) e intestinos (suboclusão, má absorção). 4 O envolvimento oral da paracoccidioidomicose possui uma apresentação clínica típica caracterizada por úl-ceras com aspecto de amora, com pontos hemorrágicos.…”

Section: Introductionunclassified

Paracoccidioidomicose com Acometimento Ganglionar e Mucoso - Relato de Caso

Prohmann

Dantas

Silva

et al. 2018

SPDV

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RESUMO -A paracoccidioidomicose (também conhecida como doença de Lutz, doença de Lutz-Splendore-Almeida, blastomicose Brasileira ou blastomicose Sul Americana) foi inicialmente descrita por Lutz há quase um século. Trata-se de uma infecção fúngica sistémica, que pode apresentar-se sob duas formas clínicas: aguda/subaguda ou crónica. As lesões orais da paracoccidioidomicose são tipicamente caracterizadas por hiperplasia gengival eritematosa e finamente granular, com petéquias. Além disso, observam-se úlceras superficiais com micro granulações e ponteados hemorrágicos, que podem envolver lábios, mucosa jugal, palato, pilares amigdalianos e língua. A superfície é semelhante à amora sendo por isso denominada de "estomatite moriforme". Apesar de comuns, essas lesões são subdiagnosticadas e o reconhecimento tardio desta patologia pode levar à rápida progressão do quadro clínico, por vezes com desfecho fatal. Relatamos o caso de um paciente jovem com adenopatias generalizadas, estomatite moriforme e sintomas constitucionais (febre, perda de peso). Destaca-se a importância do dermatologista na identificação precoce das lesões cutaneomucosas típicas da paracoccidioidomicose e no estabelecimento de um diagnóstico preciso. PALAVRAS-CHAVE - INTRODUÇÃOA paracoccidioidomicose é causada pelo fungo termo--dimórfico Paracoccidioides brasiliensis, 1-3 que apresenta uma distribuição geográfica limitada a América Central e do Sul. Quando não diagnosticada e tratada oportunamente, pode levar a formas disseminadas graves e letais, com rápido e progressivo envolvimento de pulmões, tegumento cutâneo, gânglios, baço, fígado e órgãos linfoides do tubo digestivo.¹ A prevalência de infecção por P. brasiliensis em áreas endêmicas pode chegar a 50-75% da população adulta. Felizmente, apenas cerca de 2% desenvolve alguma

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Paracoccidioidomycosis: acute-subacute clinical form, juvenile type

Cited by 5 publications

References 7 publications

Oral Paracoccidioidomycosis, Clinical Characteristics, Diagnosis and Treatment

Oral Paracoccidioidomycosis, Clinical Characteristics, Diagnosis and Treatment

Paracoccidioidomycosis in an Elderly Simulating Cholangiocarcinoma

Paracoccidioidomicose com Acometimento Ganglionar e Mucoso - Relato de Caso

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