Paracoccidioidomycosis disease (Lutz-Splendore-Almeida disease): Additional workup, differential diagnosis, cure control

Abstract

The diagnosis of paracoccidioidomycosis requires epidemiological data to be available and for the presence of some more typical clinical manifestations.It requires complementary investigation with interventional methods, differential diagnosis of pathologies of great importance such as tuberculosis and lymphomas, and cure control. This update discusses the advances in these various areas, which include complementary investigation, differential diagnosis and cure control, pointing to development prospects that may help better define the best approach to this disease.

Molecular Tools for Detection and Identification of Paracoccidioides Species: Current Status and Future Perspectives

“…Therefore, pulmonary involvement is present in nearly 90% of individuals. PCM is classified as an infection or disease, and the primary clinical forms are described as follows: (i) the acute or subacute form (juvenile), which presents rapid progression and can be considered severe due to high lethality rates in children and adolescents; (ii) the chronic form (adult), uni or multifocal, which can be mild, moderate or severe and presents slower progression, being responsible for most cases of PCM (74 to 96%); and (iii) the residual form or sequelae, which are clinical manifestations of anatomical and functional changes observed after PCM treatment [ 1 , 3 , 4 ].…”

Lymphadenitis by Paracoccidioidomycosis Mimetizing Pancreatic Head Cancer

“…The PCM gold standard diagnostic procedure is the fresh analysis of the sputum or other clinical sample and/or biopsy, with histopathological analysis of the affected organ, wich allows the visualization of fungal structures suggestive of Paracoccidioides spp. (1,2,7,10,12,13).…”

“…Therefore, the main objective of the treatment is to allow an improvement in cellular immunity by reducing the fungal load to re-establish a balance between parasite and host. (1,12,15).…”

Conhecimento de profissionais de saúde do SUS acerca da paracoccidioidomicose no município de Valença-RJ.

“…Sendo a PCM uma micose sistêmica, na investigação diagnóstica, é essencial observar o estado geral do paciente e avaliar os principais órgãos e sistemas mais frequentemente comprometidos, diferenciando-se as formas clínicas da doença aguda/subaguda e crônica. (AMBRÓSIO et al, 2014) A forma aguda/subaguda é responsável por 5 a 25% dos casos da doença, predominando em crianças e adolescentes, com distribuição semelhante entre os sexos. Essa forma clínica tem como característica uma evolução mais rápida e pode-se destacar a presença de linfonodomegalias, hepatoesplenomegalias, manifestações digestivas, lesões cutâneas e envolvimento osteoarticular como principais órgãos afetados (SHIKANAI-YASUDA et al, 2017).…”