Paracoccidioidomycosis

Bethlem, N; Lemle, A; Bethlem, Eduardo Pamplona; Wanke, Bodo

doi:10.1055/s-2007-1006229

Cited by 17 publications

(19 citation statements)

References 35 publications

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“…Similar to what has been reported previously, most cases of paracoccidioidomycosis were diagnosed among men (82% of the total), thus reinforcing the idea that, for biological or behavioural reasons, men are more susceptible to this mycosis than women [12]. It is possible that under certain occupational conditions, like farming, men are more exposed to inhaling soil dust particles at work, thus increasing the risk of paracoccidioidomycosis infection and disease [3,12]. The lower frequency of the disease observed in women may also be due to a protective effect of estrogens, as it has been shown by various authors [13].…”

Section: Discussionsupporting

confidence: 87%

“…The prevalence of this disease over other systemic mycoses is also reflected in mortality statistics, as it is the main cause of death among all mycoses in the country [8,11]. Similar to what has been reported previously, most cases of paracoccidioidomycosis were diagnosed among men (82% of the total), thus reinforcing the idea that, for biological or behavioural reasons, men are more susceptible to this mycosis than women [12]. It is possible that under certain occupational conditions, like farming, men are more exposed to inhaling soil dust particles at work, thus increasing the risk of paracoccidioidomycosis infection and disease [3,12].…”

Section: Discussionsupporting

confidence: 77%

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Hospital morbidity due to paracoccidioidomycosis in Brazil (1998–2006)

Coutinho

Wanke

Travassos

et al. 2015

Tropical Med Int Health

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Abstractobjective To analyse hospital morbidity records due to paracoccidioidomycosis in Brazil, including its nationwide distribution in time and space, as well as key epidemiological and sociodemographic characteristics.methods Descriptive analysis of hospital morbidity records due to paracoccidioidomycosis covering the period January 1998 to December 2006. Hospital records were obtained from the Hospital Information System of the Brazilian Unified Health System (SIH/SUS).results There were 6732 hospitalisations (82% male) due to paracoccidioidomycosis in the period, representing 4.3 per 1.0 million inhabitants. Admissions due to this mycosis were recorded in 27% of the 5560 Brazilian municipalities, covering 35% of the country. Ten municipalities concentrated 52% of all admissions. The temporal distribution of admissions for paracoccidioidomycosis showed a slight increase. The geographical analysis showed two distinct patterns of the disease: (i) traditional areas of southern and south-eastern regions, covering 60% of admissions, and (ii) a second pattern in northern Brazil revealed a transverse band of higher concentration with about 27% of admissions, particularly along the southern border of the Amazon region.conclusion This first nationwide analysis of hospitalisation due to paracoccidioidomycosis in Brazil shows that it is the most prevalent systemic mycosis in Brazil. Despite its importance, there are major deficits in its proper registry, diagnostics and treatment. The particular epidemiological and medical challenges of paracoccidioidomycosis will not be met while the disease continues to be perceived as an isolated infectious entity restricted to a few faraway regions of the globe.

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Section: Discussionsupporting

confidence: 87%

Section: Discussionsupporting

confidence: 77%

Hospital morbidity due to paracoccidioidomycosis in Brazil (1998–2006)

Coutinho

Wanke

Travassos

et al. 2015

Tropical Med Int Health

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“…brasiliensis is the causative agent of paracoccidioidomycosis, a disease first described in 1908 (see Goldani and Sugar 1995). It is the most common systemic mycosis in Latin America with an estimated number of infected individuals close to 10 million (Bethlem et al 1991;Brummer et al 1993). P. brasiliensis as a species was shown to consist of a number of distinct phylogenetic lineages that have recently been resolved into two species, P. brasiliensis and P. lutzii (Matute et al 2006a,b).…”

Section: Paracoccidioides Brasiliensismentioning

confidence: 99%

Thermally Dimorphic Human Fungal Pathogens—Polyphyletic Pathogens with a Convergent Pathogenicity Trait

Sil

Andrianopoulos

2014

Cold Spring Harb Perspect Med

102

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“…Based on its pathogenesis the disease may be classified in the following forms: regressive (asymptomatic infection and primary pulmonary), progressive juvenile type (acute and subacute; pulmonary or disseminated) and progressive adult type (chronic; pulmonary or disseminated) 4 . Microscopic observation of P. brasiliensis in clinical samples and its isolation in culture are the most important diagnostic findings 10 .…”

Section: Introductionmentioning

confidence: 99%