Paracrine Regulation of Thyroid-Hormone Synthesis by C Cells

Fernández-Santos, José M.; García-Marín, Rocío; Utrilla, José Carmelo; Martín-Lacave, Inés

doi:10.5772/46178

Cited by 7 publications

(14 citation statements)

References 216 publications

(189 reference statements)

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“…It falls within the range of C cells reported for other animal species. The lowest C cell concentration (less than 1%) was found in humans [7] followed by pig (3.8%) [14], some laboratory animals (mice, guinea pigs, rabbits, approximately 10-13% [9,13], rats (23.1%) [13] and dogs (20-45%) [13]). It should be noticed, that in cases of animal species in which parafollicular cells possess cytoplasmic processes, the number of C cells could vary depending on the way of C cell definition in histological sections, i.e.…”

Section: Discussionmentioning

confidence: 94%

“…2018 10.5603/FHC.a2018.0024 www.fhc.viamedica.pl and constitute a small percentage of its parenchyma. They produce calcitonin and endocrine peptides such calcitonin gene-related peptide, somatostatin and helodermin [7]. It is widely known that distribution of C cells within the thyroid lobes as well as their number and morphology vary [7][8][9] and some of these features are species-specific [9]; however, studies regarding this subject are not numerous.…”

Section: Cells In European Bison Thyroid Glandmentioning

confidence: 99%

“…They produce calcitonin and endocrine peptides such calcitonin gene-related peptide, somatostatin and helodermin [7]. It is widely known that distribution of C cells within the thyroid lobes as well as their number and morphology vary [7][8][9] and some of these features are species-specific [9]; however, studies regarding this subject are not numerous. Most of them focus on human [10] and laboratory animals [9,11,12] and less often on other domestic animals [12][13][14].…”

Section: Cells In European Bison Thyroid Glandmentioning

confidence: 99%

“…Only one paper [16] provided more detailed data on distribution of C cells in European bison thyroid gland. However, in available literature there is no information regarding the proportion of C cells to either all endocrine cell (follicular and C cells) number or follicular cells, although such studies were conducted on thyroids of humans and various mammalian species, including laboratory and domestic animals [7,8,13,14]. Moreover, no morphometric studies of European bison C cells were conducted.…”

Section: Cells In European Bison Thyroid Glandmentioning

confidence: 99%

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Immunohistochemical characteristic of C cells in European bison thyroid gland

Sokołowska

Berczynska

Poweska

et al. 2019

Folia Histochem Cytobiol.

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Introduction. C cells constitute a small percentage of thyroid gland parenchyma. The number, morphology and distribution of C cells differ among species; however, data regarding their characteristics in European bison are sparse. The aim of this study was to evaluate the morphology, distribution pattern and percentage of C cells in European bison thyroid gland together with morphometric analysis. Material and methods. Thyroid glands from 28 European bisons of different sex and age were collected either in autumn-winter (13/28) or in spring-summer (15/28) periods and analyzed by immunohistochemistry. Results. The mean total C cell number per all endocrine (follicular and C cells) cell number (C cell concentration) was 7.33%. The tendency to increase the C cell number from periphery to the central region of thyroid lobe was observed with the mean C cell concentration of 3.95%, 7.89% and 9.97% in peripheral, intermediate and central areas, respectively. Most frequently, C cells were situated intrafolliculary whereas epifollicular and interfollicular positions were observed less often. C cells were polymorphic with long cytoplasmic processes. The mean C cell area was 61.97 µm 2 and the mean C cell perimeter, length and width were: 34.92 µm, 12.85 µm and 4.91 µm, respectively. In the majority of C cells, strong immunohistochemical cytoplasmic reaction was observed with the mean color intensity of 78.32. In autumn-winter period, C cells were significantly larger with lower color intensity than during spring and summer. Conclusions. This study leads to deeper characteristics of thyroid gland C cells in European bison. The histomorphometric data suggest that in European bison production of calcitonin by C cells may differ depending on the time of the year.

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Section: Discussionmentioning

confidence: 94%

Section: Cells In European Bison Thyroid Glandmentioning

confidence: 99%

Section: Cells In European Bison Thyroid Glandmentioning

confidence: 99%

Section: Cells In European Bison Thyroid Glandmentioning

confidence: 99%

See 2 more Smart Citations

Immunohistochemical characteristic of C cells in European bison thyroid gland

Sokołowska

Berczynska

Poweska

et al. 2019

Folia Histochem Cytobiol.

View full text Add to dashboard Cite

show abstract

“…Industrial use of SD × 2 , SD × 2.5 , and SD × 3 is common, although more precise values for multiplying SD could be derived. [33] In contrast to other approaches, where a minimum effect size has to be calculated [57] or an equivalence limit defined, [58] this work utilizes scores and loadings of reduced dimensionality to determine equivalence by TOST. Judging by the results presented here, we found that using SD × was an appropriate approach.…”

Section: Case Study 1-small Datamentioning

confidence: 99%

Multivariate Data Analysis Methodology to Solve Data Challenges Related to Scale‐Up Model Validation and Missing Data on a Micro‐Bioreactor System

Goldrick

Sandner

Cheeks³

et al. 2019

Biotechnology Journal

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Multivariate data analysis (MVDA) is a highly valuable and significantly underutilized resource in biomanufacturing. It offers the opportunity to enhance understanding and leverage useful information from complex high‐dimensional data sets, recorded throughout all stages of therapeutic drug manufacture. To help standardize the application and promote this resource within the biopharmaceutical industry, this paper outlines a novel MVDA methodology describing the necessary steps for efficient and effective data analysis. The MVDA methodology is followed to solve two case studies: a “small data” and a “big data” challenge. In the “small data” example, a large‐scale data set is compared to data from a scale‐down model. This methodology enables a new quantitative metric for equivalence to be established by combining a two one‐sided test with principal component analysis. In the “big data” example, this methodology enables accurate predictions of critical missing data essential to a cloning study performed in the ambr15 system. These predictions are generated by exploiting the underlying relationship between the off‐line missing values and the on‐line measurements through the generation of a partial least squares model. In summary, the proposed MVDA methodology highlights the importance of data pre‐processing, restructuring, and visualization during data analytics to solve complex biopharmaceutical challenges.

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Engineered Insulin Secretion from Neuroendocrine Cells Isolated From Human Thyroid

et al. 2014

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Human thyroid NE cells can produce human insulin, fractions of which are both secreted and retained in secretory granules. Overexpression of HNF6, PDX1, or NGN3 enhances expression of both hepatocyte and beta cell typical mRNAs, including the message of proteins critical for glucose sensing. These data suggest that reimplantation of engineered autologous NE cells may develop as a viable treatment for diabetes mellitus type 1.

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Paracrine Regulation of Thyroid-Hormone Synthesis by C Cells

Cited by 7 publications

References 216 publications

Immunohistochemical characteristic of C cells in European bison thyroid gland

Immunohistochemical characteristic of C cells in European bison thyroid gland

Multivariate Data Analysis Methodology to Solve Data Challenges Related to Scale‐Up Model Validation and Missing Data on a Micro‐Bioreactor System

Engineered Insulin Secretion from Neuroendocrine Cells Isolated From Human Thyroid

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