Paracrine signaling in stem cell renewal and in neoplastic tumor growth

Zhao, Chunxia

doi:10.1007/s11427-014-4664-8

Cited by 5 publications

(3 citation statements)

References 23 publications

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“…Transforming growth factor  (TGF-), Wnt and hedgehog signaling are pivotal pathways that influence the cell division, invasion, migration and ulcer repair processes Lagasse, 2008;Zhao, 2014). Disorders in these processes usually lead to gastric adenocarcinoma and other tissue-specific gastrointestinal cancers (Stojnev et al, 2014).…”

Section: Stem Cell Pathwaysmentioning

confidence: 99%

Genomic landscape of gastric cancer: molecular classification and potential targets

Guo

et al. 2016

Sci. China Life Sci.

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Gastric cancer imposes a considerable health burden worldwide, and its mortality ranks as the second highest for all types of cancers. The limited knowledge of the molecular mechanisms underlying gastric cancer tumorigenesis hinders the development of therapeutic strategies. However, ongoing collaborative sequencing efforts facilitate molecular classification and unveil the genomic landscape of gastric cancer. Several new drivers and tumorigenic pathways in gastric cancer, including chromatin remodeling genes, RhoA-related pathways, TP53 dysregulation, activation of receptor tyrosine kinases, stem cell pathways and abnormal DNA methylation, have been revealed. These newly identified genomic alterations await translation into clinical diagnosis and targeted therapies. Considering that loss-of-function mutations are intractable, synthetic lethality could be employed when discussing feasible therapeutic strategies. Although many challenges remain to be tackled, we are optimistic regarding improvements in the prognosis and treatment of gastric cancer in the near future. gastric cancer, chromatin remodeling, RhoA, p53, receptor tyrosine kinase, DNA methylation Citation:

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Section: Stem Cell Pathwaysmentioning

confidence: 99%

Genomic landscape of gastric cancer: molecular classification and potential targets

Guo

et al. 2016

Sci. China Life Sci.

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“…The important distinction of this focus is the long and interesting list of cellular features that all adult stem cells have in common, not on the complex spectrum of distinctive phenotypes that the stem cells can become. The unexpected and simplifying conclusion is that all adult stem cells have a similar profound paracrine activity that is essential for the normal turnover and regeneration especially active and discernable at sites of injury [1][2][3][4][5][6].…”

Section: Introductionmentioning

confidence: 99%

Are All Adult Stem Cells The Same?

Caplan

2015

Regen. Eng. Transl. Med.

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Every adult tissue has its own resident committed progenitor or stem cell. In addition, there exists a class of adult stem cells that are multipotent and/or have injury-specific functions. Mesenchymal stem cells (MSCs) are quite different in comparison with neural stem cells (NSCs) when focusing on the range of different differentiated cell types that can develop from their progeny. These striking differences aside, MSCs, NSCs, and hematopoietic stem cells (HSC) have a very striking number of similarities. They are all dominant cells, multipotent, have a well-defined niche on or in contact with blood vessels, they all actively sense and respond to their local environment, they are all paracrine secretors, they are all immune-modulatory and trophic, and they all have a profound effect on site-specific regeneration following injury. These similarities, especially their unique interactions and association with vasculature, distinguish these adult cells from their embryonic progenitors and by virtue of these similarities define these unique adult stem cells. Lay Summary The adult body has many stem cells, at least one for every major tissue. These stem cells provide the basis for the maintenance, repair, and regeneration of these tissues. These stem cells can divide and differentiate into a specialized tissue like muscle or liver. However, stem cells from different tissues have a common core of properties that are similar in function. For example, the hematopoietic stem cell (HSC) produces all the cells in blood. The mesenchymal stem cell (MSC) can produce fat or bone. The HSC and MSC function at tissue sites of injury to cause the tissue to regenerate. Thus, the HSC and MSC do the same injury function although they are uniquely different. Moreover, each stem cell establishes a unique habitat next to or in contact with blood vessels.

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“…Zhao Chen [4], in his article, discussed paracrine signaling activities in stem cell renewal and neoplastic tumor growth. The interaction between epithelial cells and stromal cells is key to embryonic development, adult tissue homeostasis and tumorigenesis.…”

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confidence: 99%

Introduction to the special topic “Stem cells and regenerative medicine”

Chen

2014

Sci. China Life Sci.

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Paracrine signaling in stem cell renewal and in neoplastic tumor growth

Cited by 5 publications

References 23 publications

Genomic landscape of gastric cancer: molecular classification and potential targets

Genomic landscape of gastric cancer: molecular classification and potential targets

Are All Adult Stem Cells The Same?

Introduction to the special topic “Stem cells and regenerative medicine”

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