Paradigm Shift in Radiation Biology/Radiation Oncology—Exploitation of the “H2O2 Effect” for Radiotherapy Using Low-LET (Linear Energy Transfer) Radiation such as X-rays and High-Energy Electrons

Ogawa, Yasuhiro

doi:10.3390/cancers8030028

Cited by 48 publications

(57 citation statements)

References 30 publications

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“…However, hydrogen peroxide also has an effect of inactivating antioxidative enzymes such as peroxidases and catalases that scavenge radicals produced by irradiation and reduce the therapeutic effect of irradiation. 26 We, alongside our patients, wish to control the tumor with a probability of nearly 100%. Therefore, we will continue to use KORTUC for tumors of 2 cm or larger in diameter.…”

Section: Discussionmentioning

confidence: 99%

Definitive Radiotherapy With SBRT or IMRT Boost for Breast Cancer: Excellent Local Control and Cosmetic Outcome

Shibamoto

Murai

Suzuki

et al. 2018

Technol Cancer Res Treat

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The gold standard for breast cancer treatment is surgery, but many women may desire to avoid surgery if possible. The purpose of this study was to evaluate whether breast cancer could be cured with modern sophisticated radiation techniques with good cosmetic outcome. We have treated 18 patients with operable breast cancer by conventional whole-breast irradiation followed by stereotactic body radiotherapy (primary tumor only) or intensity-modulated radiotherapy (tumor plus axillary nodes) boost. The planned doses were 50 Gy in 25 fractions, 18 to 25.5 Gy in 3 fractions, and 20 Gy in 8 fractions, respectively, for the 3 modalities. Stereotactic body radiotherapy was delivered with 7 to 9 coplanar and noncoplanar fixed beams, and intensity-modulated radiotherapy was given by tomotherapy. Chemotherapy and/or hormone therapy was used depending on the stage and receptor status. In 9 recent patients, hydrogen peroxide was intratumorally injected twice a week before whole-breast irradiation. All treatments were well tolerable and there were no grade ≥3 toxicities. With a median follow-up period of 35 months (range, 8-120 months), only 1 patient developed local recurrence and 2 patients developed distant metastasis. Overall survival, progression-free survival, and local control rates were 93%, 85%, and 92%, respectively, at 3 years. In 50% of the patients, the irradiated breast became better rounded, and the position of the nipple of the irradiated breast became ≥1 cm higher compared to that of the unirradiated breast. Thus, the treated breasts may be more aesthetically favorable than before irradiation in these patients. This may become a treatment option for patients with operable breast cancer.

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Section: Discussionmentioning

confidence: 99%

Definitive Radiotherapy With SBRT or IMRT Boost for Breast Cancer: Excellent Local Control and Cosmetic Outcome

Shibamoto

Murai

Suzuki

et al. 2018

Technol Cancer Res Treat

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“…Cytotoxicity of radiation is usually attributed to the •OH‐induced DNA double‐strand breaks (DSBs). [ 40,41 ] As mentioned above, we designed 125 I‐TiO 2 to improve the yield of •OH in IRT. Hence, we initially measured the generation of intracellular •OH using a hydroxyphenyl fluorescein probe.…”

Section: Methodsmentioning

confidence: 99%

Auger Electrons Constructed Active Sites on Nanocatalysts for Catalytic Internal Radiotherapy

Wang

et al. 2020

Advanced Science

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Excess electrons play important roles for the construction of superficial active sites on nanocatalysts. However, providing excess electrons to nanocatalysts in vivo is still a challenge, which limits the applications of nanocatalysts in biomedicine. Herein, auger electrons (AEs) emitted from radionuclide 125 (125I) are used in situ to construct active sites in a nanocatalyst (TiO2) and the application of this method is further extended to cancer catalytic internal radiotherapy (CIRT). The obtained 125I‐TiO2 nanoparticles first construct superficial Ti3+ active sites via the reaction between Ti4+ and AEs. Then Ti3+ stretches and weakens the OH bond of the absorbed H2O, thus enhancing the radiolysis of H2O molecules and generating hydroxyl radicals (•OH). All in vitro and in vivo results demonstrate a good CIRT performance. These findings will broaden the application of radionuclides and introduce new perspectives to nanomedicine.

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“…Physical protection is essential to prevent the direct effects of radiation. It also affects the body indirectly, as when radiation hits water molecules in host cells, it produces large amounts of free radicals and reactive oxygen species (ROS), which then oxidize the cell components, resulting in cell injuries [7][8][9][10] (Figure 1).…”

Section: Introductionmentioning

confidence: 99%

Radioprotective Effect of Vitamin C as an Antioxidant

Yamamoto¹,

Kinoshita²

2017

Vitamin C

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Vitamin C is known as a potent antioxidant. We studied vitamin C as a radioprotective agent, focusing on its antioxidative effect. When the body is exposed to radiation, free radicals and reactive oxygen species (ROS) are produced and oxidize cell components, resulting in cell damage. Vitamin C has the potential to scavenge these radical products, thereby protecting against radiation-induced cell damage. We investigated the effects of vitamin C on radiation-induced gastrointestinal (GI) syndrome in mice. The mice received whole-body irradiation followed by bone marrow transplantation 24 h after exposure. Despite avoiding bone marrow failure, the mice eventually died of GI syndrome. Pretreatment with per os administration of high-dose vitamin C effectively mitigated radiation-induced GI syndrome and improved mouse survivals, while per os post-treatment with vitamin C was ineffective, presumably due to impaired absorption from the radiation-damaged intestine. We also investigated the effect of post-exposure treatment with intraperitoneal administration of vitamin C on radiation-induced bone marrow dysfunction in mice. Intraperitoneal administration with high-dose vitamin C, even at 24 h after whole-body irradiation, was still effective in avoiding bone marrow dysfunction, thereby increasing mouse survival after radiation. In conclusion, administration of high-dose vitamin C effectively reduced the radiation lethality in mice.

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Paradigm Shift in Radiation Biology/Radiation Oncology—Exploitation of the “H2O2 Effect” for Radiotherapy Using Low-LET (Linear Energy Transfer) Radiation such as X-rays and High-Energy Electrons

Cited by 48 publications

References 30 publications

Definitive Radiotherapy With SBRT or IMRT Boost for Breast Cancer: Excellent Local Control and Cosmetic Outcome

Definitive Radiotherapy With SBRT or IMRT Boost for Breast Cancer: Excellent Local Control and Cosmetic Outcome

Auger Electrons Constructed Active Sites on Nanocatalysts for Catalytic Internal Radiotherapy

Radioprotective Effect of Vitamin C as an Antioxidant

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