Paradigm shift in theranostics of neuroendocrine tumors: conceptual horizons of nanotechnology in nuclear medicine

Abstract

We present a comprehensive review of Neuroendocrine Tumors (NET) and the current and developing imaging and therapeutic modalities for NET with emphasis on Nuclear Medicine modalities. Subsequently, nanotechnology and its emerging role in cancer management, especially NET, are discussed. The article is both educative and informative. The objective is to provide an insight into the developments made in nuclear medicine and nanotechnology towards management of NET, individually as well as combined together.

Continuing challenges of primary neuroendocrine tumours of the thymus: A concise review

“…The dose limiting factor in PPRT is nephrotoxicity, due to renal uptake of the radioisotope, with reported renal exposure of up to 37 Gy [83]. This nephrotoxicity may be minimised by competitively inhibiting reabsorption at the proximal tubule with the positively charged amino acids arginine and lysine or by using the radioprotectant amifostin [84].…”

Biocatalyst immobilization on magnetic nano‐architectures for potential applications in condensation reactions

“…In this scenario, single‐domain magnetic nanoparticle showing superparamagnetism at room temperature represent an interesting playground for fundamental study. Moreover, the wide presence of MNPs in nature and in living systems makes them of interest in different branches of science with a large spectrum of applications: paleomagnetism (Lagroix & Guyodo, 2017; Newell, 2017; Yan et al., 2012), geology (Morales et al., 1997), mineralogy, cultural heritage (archaeology, paintings) (Rao et al., 2015), catalysis (Arizzi et al., 2015; Cunha et al., 2018; Gawande et al., 2013; Skliri et al., 2018), surface chemistry (Lykaki et al., 2018; Simo et al., 2018; Turcheniuk et al., 2013), biomagnetic separation (Fields et al., 2016; Hofman et al., 2017), medicine theragnostic of tumours (Arora & Bandopadhyaya, 2018; Gazeau et al., 2008; Hameed et al., 2018) and tissue engineering (Cagil et al., 2018; Leferink et al., 2018; Pankhurst et al., 2003), magnetic recording (López‐Ortega et al., 2015; Malek et al., 2018; Manzoor et al., 2018), permanent magnets (Chahal & Samra, 2018; Li et al., 2003; Lu et al., 2007), sensors (Cao et al., 2018; Dong et al., 2018; Rocha‐Santos, 2014), ferrofluid‐based devices (Felicia & Philip, 2015; Kuzhir et al., 2017; Seol et al., 2017), high frequency power applications (Felicia & Philip, 2015; Hayashi et al., 2010; Helal et al., 2018; Mondal et al., 2016) and magneto optical devices (da Silva et al., 2019).…”