Paradigm Shifts in Fungal Secondary Metabolite Research: Unusual Fatty Acids Incorporated into Fungal Peptides

Dembitsky, Valery M.

doi:10.20546/ijcrbp.2017.412.002

Cited by 7 publications

(2 citation statements)

References 168 publications

(135 reference statements)

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“…[(E)-6,6,6-trichloro-5-methylhex-2-enoic acid, 62)] from Dysidea (Dembitsky, 2017). (S)-7,7-Dichloro-3-hydroxy-2,2-dimethyloctanoic acid is incorporated into many lipopeptides predominantly in cyanobacteria like Lyngby sp.…”

Section: Lipidsmentioning

confidence: 99%

Halogenated Antimicrobial Agents to Combat Drug-Resistant Pathogens

Faleye,

Boya,

Lee

et al. 2023

Pharmacol Rev

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Antimicrobial resistance presents us with a potential global crisis as it undermines the abilities of conventional antibiotics to combat pathogenic microbes. The history of antimicrobial agents is replete with examples of scaffolds containing halogens. In this review, we discuss the impacts of halogen atoms in various antibiotic types and antimicrobial scaffolds and their modes of action, structure-activity relationships, and the contributions of halogen atoms in antimicrobial activity and drug resistance. Other halogenated molecules, including carbohydrates, peptides, lipids, and polymeric complexes, are also reviewed, and the effects of halogenated scaffolds on pharmacokinetics, pharmacodynamics, and factors affecting antimicrobial and antivirulence activities are presented. Furthermore, the potential of halogenation to circumvent antimicrobial resistance and rejuvenate impotent antibiotics is addressed. This review provides an overview of the significance of halogenation, the abilities of halogens to interact in biomolecular settings and enhance pharmacological properties, and their potential therapeutic usages in preventing a post-antibiotic era. Significance StatementAntimicrobial resistance and the increasing impotence of antibiotics are critical threats to global health. The roles and importance of halogen atoms in antimicrobial drug scaffolds have been established, but comparatively little is known of their pharmacological impacts on drug resistance and antivirulence activities. This review is the first to extensively evaluate the roles of halogen atoms in various antibiotic classes and pharmacological scaffolds and to provide an overview of their abilities to overcome antimicrobial resistance.

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Section: Lipidsmentioning

confidence: 99%

Halogenated Antimicrobial Agents to Combat Drug-Resistant Pathogens

Faleye,

Boya,

Lee

et al. 2023

Pharmacol Rev

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“…[40] Three 5,6-epoxy secosterols were found in soft coral Lobophytum sp. (13) [41] and sponge Aplysilla glacialis (14 and 15), [42] respectively. Both sekosterols (14 and 15) isolated from the sponge showed anticancer activity.…”

Section: Steroids Bearing 56-epoxy Groupmentioning

confidence: 99%

Naturally occurring marine α,β‐epoxy steroids: Origin and biological activities

Dembitsky

Gloriozova

Poroikov

2018

Vietnam Journal of Chemistry

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The present review describes the biological activities of more than 100 marine α,β‐epoxy steroids. These steroids have been isolated from marine invertebrates including, sponges, starfish, soft corals and nudibranch (Mollusca). We used the computer program PASS and based on structure‐activity relationships (SAR), which contains more than one million chemical compounds and more than 8,000 biological activities. The most frequently predicted activities are anti‐neoplastic, anti‐inflammatory, anti‐fungal and other activities are identified with a certainty of 76 to 94 percent. The main activities for different groups of steroids differ significantly.

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Boronolipids

Dembitsky

2024

Vietnam Journal of Chemistry

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The interactions between boron and polyols significantly impact the functioning of bioactive metabolites, algae, plant growth, and quorum determination in certain bacterial species. This wide array of boron‐inclusive compounds aligns with the expectation as boron ranks among the top ten most plentiful elements in seawater. Moreover, carbohydrates, largely comprising polyols, represent the most abundant class of biomass on earth. Lately, the complexes formed between boron and sugars have garnered interest. They have been employed to construct synthetic carbohydrate receptors. These complexes are typified by covalent interactions, enabling their conversion into aqueous solutions. The physical and chemical traits of boron and its established compounds suggest the feasibility of generating boron‐based lipids and glycolipids. Building upon the chemical and mathematical models that demonstrate the formation of protomembranes and biological membranes from complex lipids using low molecular weight polyols as their framework, it appears that the abiotic synthesis of boronolipids follows a parallel route. This review offers a succinct overview of naturally occurring boron compounds and delves into the possible existence of boronolipids within the makeup of protomembranes and biological membranes.

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Paradigm Shifts in Fungal Secondary Metabolite Research: Unusual Fatty Acids Incorporated into Fungal Peptides

Cited by 7 publications

References 168 publications

Halogenated Antimicrobial Agents to Combat Drug-Resistant Pathogens

Halogenated Antimicrobial Agents to Combat Drug-Resistant Pathogens

Naturally occurring marine α,β‐epoxy steroids: Origin and biological activities

Boronolipids

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