The epistemology which sees intra-specific and intra-group heterogenization, symbiotization, interactive pattern-generating and change as basic principles produces types of theories and research strategies different from the epistemology based on the notions of intra-specific and intra-group uniformity, competition and stabilization. In the uniformistic view, individual variations have been reduced mainly either to statistical deviations from the mean or to dominance relationship. On the other hand in the heterogenistic view, mutual beneficial interactions between qualitatively heterogeneous individuals within a group is regarded as indispensable for the increase of the level of behavioral and biological sophistication and evolution. This article compares five epistemologies including the two mentioned above in the context of the current epistemological transition in science, particularly due to the emergence of non-equilibrium thermodynamics in physics and differentiation-amplifying reciprocal causal models in mathematics and engineering, both of which consider the universe as pattern-generating, informationcreating and evolving.Recent advances in several fields of science indicate that the basic principle of biological and social, and even some physical processes is increase of heterogeneity and symbiotization. This is a marked contrast to the still quite prevalent view which regards uniformity and homogeneity as being more basic than heterogeneity.New developments in 'hard' science, particularly non-equilibrium thermodynamics in physics and differentiation-amplifying reciprocal causal models in mathematics and engineering, have produced a cosmology in which reciprocal causal interactions create new patterns, generate heterogeneity and structures, and increase the amount of information. Such processes were impossible or inexplicable under the theory of equilibrium thermodynamics and Shannon's information theory.This change is more than a theoretical innovation. It is an epistemological* * In this article the term 'epistemology' is used in the sense of'structure of reasoning and structure of universe resulting from that structure of reasoning'. It may be useful to distinguish three levels: level of theories; level of logics; and level of epistemologies. For example, the Euclidean geometry and the non-Euclidean geometry are different theories within the same deductive bivalue logic. At another level, the bi-value logic, the multi-value logic and the continuous-value