2024
DOI: 10.20944/preprints202405.0063.v1
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Paradoxes: Cholesterol and Hypoxia in Preeclampsia

Nancy R Hart

Abstract: Preeclampsia, a hypertensive disease of pregnancy of unknown etiology, is intensely studied as a model of cardiovascular (CVD) disease not only due to multiple shared pathologic elements, but also because changes that develop over decades in CVD disease appear and resolve within days in preeclampsia. Those affected by preeclampsia and their offspring experience increased lifetime risks of CVD. At the systemic level, preeclampsia is characterized by increased cellular, membrane, and blood levels of cholesterol,… Show more

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