1980
DOI: 10.1007/bf02408525
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Paradoxical effect of 1.25 dihydroxycholecalciferol on osteoblastic and osteoclastic activity in the skeleton of the eelAnguilla anguilla L

Abstract: Female mature eels (300 to 500 g) received one intraperitoneal injection of 1.25(OH)2D3 (10 microgram). Their vertebral bone was compared, 8 h and 24 h after the injection, with vertebral bone of control mature female eels receiving solvent alone (ethanol). Sexual maturation in female eels induces a bone decalcification with hypercalcaemia and hyperphosphataemia. The control eels showed marked osteoclastic resorption and osteocytic osteolysis and the degree of mineralization of the intercellular substance decr… Show more

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Cited by 37 publications
(31 citation statements)
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“…This demineralization, at least in immature European eels, was reported to be stimulated by the hormone 1,25-dihydroxyvitamin D 3 (Lopez et al 1977). However, in mature female eels in which the skeleton was already considerably demineralized, the same hormone stimulated bone formation, inhibited osteoclastic resorption and still induced a rise in plasma Pi (Lopez et al 1980). The data in the present paper now appears to explain the apparent paradox in the latter paper.…”
Section: Discussionsupporting
confidence: 42%
“…This demineralization, at least in immature European eels, was reported to be stimulated by the hormone 1,25-dihydroxyvitamin D 3 (Lopez et al 1977). However, in mature female eels in which the skeleton was already considerably demineralized, the same hormone stimulated bone formation, inhibited osteoclastic resorption and still induced a rise in plasma Pi (Lopez et al 1980). The data in the present paper now appears to explain the apparent paradox in the latter paper.…”
Section: Discussionsupporting
confidence: 42%
“…This conclusion is supported by the higher plasma total and plasma free calcium concentrations coupled with the much higher efflux rates seen in these fish. Further, an increased turnover is consistent with the vitamin D 3 stimulated increase in intestinal calcium absorption reported in European eels (Lopez et al 1980), American eels (Fenwick et al 1984) and goldfish (Fenwick 1984). It should be noted that in the marine cod, Gadus morhua, Sundell and Bj6rnsson (1990) found that 25-(OH)-D 3 but not vitamin D 3 stimulated intestinal calcium absorption in vitro.…”
Section: Discussionsupporting
confidence: 70%
“…1,25-(OH2)-D 3 increases the turnover rate of bone without affecting whole animal calcium turnover. This effect on bone is supported by observations in the European eel where this seco-steroid stimulated the differentiation of osteoblasts and osteoblastic activity without reducing osteocytic osteolysis or bone mineralization (Lopez et al 1980). It should be kept in mind that we measured calcium efflux rates and the specific activities of radiocalcium 40h after the injection of the radiolabel and the vitamins.…”
Section: Discussionsupporting
confidence: 50%
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“…The role of lymphocytes in inflammation is similar to that in mammals and the macrophages are phagocytic. A significant difference between the cartilaginous elasmobranchs and the bony teleosts is that osteoclasts are found only in the bony fish (Lopez et al, 1980;Huysseune and Sire 1992;Hughes et al, 1994). Typical multinucleated osteoclasts are described and they were shown to resorb both bone and Meckel's cartilage.…”
Section: Discussionmentioning
confidence: 94%