Paradoxical Hidradenitis Suppurativa during Biologic Therapy, an Emerging Challenge: A Systematic Review

Ruggiero, Angelo; Picone, Vincenzo; Marano, Laura; Fabbrocini, Gabriella; Marasca, Claudio

doi:10.3390/biomedicines10020455

Cited by 42 publications

(31 citation statements)

References 52 publications

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“…Indeed, patients affected by both diseases require personalized therapies and continuous follow-up. [20][21][22][23][24] As regards acne, several studies have been reported. Indeed, acne was the main field of application of telemedicine during the pandemic and the use of this tool for acne management has been investigated also before COVID-19 period.…”

Section: Teledermatology Acne and Hidradenitis Suppurativamentioning

confidence: 99%

The Role of Teledermatology During the COVID-19 Pandemic: A Narrative Review

Ruggiero¹,

Fabbrocini²,

Villani³

et al. 2022

CCID

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Teledermatology represented one of the most important and useful tools during the COVID-19 pandemic era. Indeed, due to the severe restriction, and to reduce the spread of the infection, different measures were applied among different countries and hospitals to ensure a continuity of care for patients. In this scenario, teledermatology played a central role, especially in the management of patients suffering from chronic inflammatory skin diseases. The aim of this narrative review is to describe the role of teledermatology during the COVID-19 pandemic to analyze main strengths and limitations of this tool, as well as to provide future perspectives in clinical applications.

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Section: Teledermatology Acne and Hidradenitis Suppurativamentioning

confidence: 99%

The Role of Teledermatology During the COVID-19 Pandemic: A Narrative Review

Ruggiero¹,

Fabbrocini²,

Villani³

et al. 2022

CCID

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“…The above-mentioned treatments have a positive effect on the reduction of acne lesions, reduction of the level of sebum on the surface of the epidermis, and improvement of skin hydration [ 25 , 26 ]. We hope that our research results and the treatments that we have proposed, can be used by other researchers to apply them to another disease, for example hidradenitis suppurativa [ 27 , 28 , 29 ].…”

Section: Discussionmentioning

confidence: 99%

Efficacy of Hydrogen Purification and Cosmetic Acids in the Treatment of Acne Vulgaris: A Preliminary Report

Chilicka

Rusztowicz

Rogowska

et al. 2022

JCM

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Acne and skin lesions that appear in its course deteriorate the quality of life of patients, cause depression and the emergence of suicidal thoughts. Cosmetic treatments can have a positive effect on improving skin condition by cleaning up skin eruptions, thus improving the well-being of affected people. Hydrogen purification is a treatment that uses alkaline water generated by a device, which reduces sebum from the surface of the epidermis. This is a novel treatment that has recently been introduced to beauty salons. On the other hand, cosmetic acids have been used for many years for treating people with acne vulgaris and give spectacular results in terms of improving the skin condition. In this study, skin condition was evaluated with a Derma Unit SSC 3 device. The Global Acne Grading System (GAGS) was used to check acne severity. Twenty-four women aged 19–21 years (M = 20.13, SD = 0.80) diagnosed with mild acne vulgaris and a high sebum level participated in the study. Group A underwent a hydrogen purification treatment using an H2jet manipulator, which ejected alkaline water from the manipulator under pressure. Group B underwent a hydrogen purification treatment with the use of a phytic, pyruvic, lactic and ferulic acids at 40% mixture (pH 1.4). A series of four treatments was performed at 14-day intervals in both groups. Skin parameters were measured before and 30 days after the series of treatment. Very good results were obtained in both groups. The skin eruptions in patients were reduced and we also observed lower amounts of sebum on the surface of the epidermis, and an improvement in skin hydration. However, in group B, the results were better than in group A. The study showed that the synergy of the treatments produced much better effects than those obtained by completing the hydrogen purification treatment alone.

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“…Particularly, IL-23 has been showed to regulate T-cells production of high IL-17, resulting in a self-amplifying inflammatory response in keratinocytes, and finally in the development of typical psoriasis. [93][94][95][96] In this context, recent major research advancements resulted in the development of new biological drugs specifically inhibiting the key function played by IL23. 97 Anti-IL23 drugs (guselkumab, risankizumab, and tildrakizumab) represent the latest class of biologics approved in the treatment of moderate to severe psoriasis.…”

Section: Anti-il23mentioning

confidence: 99%

Towards Personalized Medicine in Psoriasis: Current Progress

Camela¹,

Potestio²,

Ruggiero³

et al. 2022

PTT

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Although innovative targeted therapies have positively revolutionized psoriasis treatment shifting treatment goals to complete or almost complete skin clearance, primary or secondary lack of efficacy is still possible. Hence, identifying robust biomarkers that reflect the various clinical psoriasis phenotypes would allow stratify patients in subgroups or endotypes, and tailor treatments according to the characteristics of each individual (precision medicine). To sum up the current progress in personalized medicine for psoriasis, we performed a review on the available evidence on biomarkers predictive of response to psoriasis treatments, with focus on phototherapy and systemic agents. Relevant literature published in English was searched for using the following databases from the last five years up to March 20, 2022: PubMed, Embase, Google Scholar, EBSCO, MEDLINE, and the Cochrane library. Currently, more evidence exists towards biologicals, as justified by the huge health care costs as compared to phototherapy or conventional systemic drugs. Among them, most of the studies focused on anti-TNF and IL12/23, with still few on IL17 (mainly secukinumab). The most discussed biomarker gene is the HLA-C*02:06 status that has been shown to be associated with psoriasis, and also differential response to biologicals. Although its positivity is associated with great response to MTX, debatable results were retrieved concerning both anti-TNF and IL12/23 while it seems not to affect secukinumab response. Personalized treatment in psoriasis would provide excellent outcome minimizing the risk of side effects. To date, although several candidates were proposed and assessed, the scarcity and heterogeneity of the results do not allow the identification of the gold-standard biomarker per each treatment. Anyway, the creation of a more comprehensive panel would be more reliable for the treatment decision process.

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Paradoxical Hidradenitis Suppurativa during Biologic Therapy, an Emerging Challenge: A Systematic Review

Cited by 42 publications

References 52 publications

The Role of Teledermatology During the COVID-19 Pandemic: A Narrative Review

The Role of Teledermatology During the COVID-19 Pandemic: A Narrative Review

Efficacy of Hydrogen Purification and Cosmetic Acids in the Treatment of Acne Vulgaris: A Preliminary Report

Towards Personalized Medicine in Psoriasis: Current Progress

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