Paradoxical kinesia induced by nightmare: unique case report and insights regarding the neural mechanism based on human and rat studies

Abstract

In this report, we discuss a patient who is suffering from advanced Parkinson's disease. The patient has severe motor limitations, including difficulty rising from bed and walking, as well as cognitive decline and visual impairment. However, an interesting occurrence took place during a nightmare episode. Surprisingly, the patient was able to get out of bed and quickly run away from the perceived threat within the nightmare, without any assistance. This phenomenon, known as paradoxical kinesia, raises questions about the neurological mechanisms involved, which are still not fully understood. In our discussion, we will explore potential explanations based on existing research conducted on both animal and human subjects.