Paradoxical psoriasis induced by anti‐ TNF ‐alpha successfully treated with brodalumab

Abstract

pro-inflammatory protein kinases and chemokines. 3 Paradoxical psoriasis is reported in relation to biologics, included brodalumab. 4,5 Many conditions must be considered when selecting the best treatment for psoriasis. iTNF-induced psoriasis should now be added to that list. 6,7 In the literature there are not other reports on the use of brodalumab in paradoxical psoriasis. In our case report, brodalumab proved to be effective and well-tolerated for the treatment of paradoxical reaction induced by iTNF with rapid action and no adverse effects in the short follow-up. Further studies are needed to identify new recommended strategies to better manage these patients.

Paradoxical psoriasis: The flip side of idiopathic psoriasis or an autocephalous reversible drug reaction?

“…The choice of substitutive biological agent depends on different diseases. For example, tocilizumab and rituximab are appropriate for RA; ixekizumab, ustekinumab and brodalumab [ 85 ] are suitable for psoriasis; ustekinumab and vedolizumab are optional for inflammatory bowel disease [ 77 , 83 ]; and secukinumab in pyoderma gangrenosum [ 86 ].…”

New‐onset psoriasis after Comirnaty ( BNT162b2 , BioNTech /Pfizer) vaccine successfully treated with ixekizumab

“…It is known that many drugs or vaccines can be associated with the psoriasis flare‐up. 5 , 7 , 8 The most common cutaneous adverse effects reported after COVID‐19 vaccination include local injection‐site reactions, delayed large local reactions, urticarial eruptions, morbilliform reactions, herpes zoster, herpes simplex flares, and pityriasis rosea‐like reactions. 7 Currently, there is no well‐understood pathologic mechanism for new‐onset or flares of psoriasis following vaccination.…”