2016
DOI: 10.1155/2016/6748947
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Paradoxical Reaction to Alprazolam in an Elderly Woman with a History of Anxiety, Mood Disorders, and Hypothyroidism

Abstract: With less than 1% of patients who use benzodiazepines being affected, paradoxical responses to benzodiazepines are rare. In this case report, we outline the course of an 80-year-old female who developed a paradoxical response to benzodiazepines. Significant medical and psychiatric history includes anxiety, mood disorder, hypothyroidism, bilateral mastectomy, goiter removal, and triple bypass. The patient presented with mental status changes, anxiety, motor restlessness, and paranoia. Over time, a temporal rela… Show more

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Cited by 5 publications
(3 citation statements)
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“…The mechanism of paradoxical reaction to midazolam is not yet fully understood. Several factors including age, gender, history of alcohol consumption, dose administrated, underlying emotional and psychiatric disorders, and genetic predisposition are thought to increase the risk of paradoxical reaction[ 6 , 8 , 12 , 13 ]. Notably, one study reported that identical twin men experienced similar paradoxical reactions[ 14 ].…”
Section: Discussionmentioning
confidence: 99%
“…The mechanism of paradoxical reaction to midazolam is not yet fully understood. Several factors including age, gender, history of alcohol consumption, dose administrated, underlying emotional and psychiatric disorders, and genetic predisposition are thought to increase the risk of paradoxical reaction[ 6 , 8 , 12 , 13 ]. Notably, one study reported that identical twin men experienced similar paradoxical reactions[ 14 ].…”
Section: Discussionmentioning
confidence: 99%
“…Some of the common adverse effects noted with alprazolam include drowsiness, fatigue, and dizziness in the short term 13 . Some people have paradoxical activation 14 or insomnia with alprazolam. Other less common adverse effects of alprazolam include slurred speech, diaphoresis, headache, gastrointestinal disturbances, blurred vision, appetite changes, edema, dry mouth, stuffy nose, and decreased libido 13 .…”
Section: Potential Ill Effects Of Alprazolammentioning
confidence: 99%
“…A case report presented by Kirkpatrick et al 42 in 2016 details a paradoxical response to alprazolam which had recently been increased from .5 mg to 1 mg 4 times daily. Their 80-year-old patient exhibited motor agitation, an inability to sit still at first thought to be akathisia (but unresponsive to benztropine), and symptoms noted to have been progressively worsening.…”
Section: Prior Case Presentationsmentioning
confidence: 99%