Paradoxical sleep and memory: Long-term disruptive effects of anisomycin

Gutwein, Baruch M.; Shiromani, Priyattam J.; Fishbein, William

doi:10.1016/0091-3057(80)90040-4

Cited by 32 publications

(16 citation statements)

References 22 publications

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“…The focus on REM sleep as the sleep stage that supports memory has also been criticized by several studies revealing concomitant or even selective increases in non-REM sleep after the animal's exposure to enriched environments or other learning procedures (389,493,495,510,529,540,645,1092,1104,1168). Non-REM sleep was even proposed as a factor that could explain REM sleep-deprivation-induced memory deficits (992), and increases in non-REM sleep after fear conditioning correlated with the learned fear response on the next day (62).…”

Section: B Rem Sleep and Memory Consolidationmentioning

confidence: 99%

About Sleep's Role in Memory

Rasch

Born

2013

Physiological Reviews

2,270

2,026

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Over more than a century of research has established the fact that sleep benefits the retention of memory. In this review we aim to comprehensively cover the field of "sleep and memory" research by providing a historical perspective on concepts and a discussion of more recent key findings. Whereas initial theories posed a passive role for sleep enhancing memories by protecting them from interfering stimuli, current theories highlight an active role for sleep in which memories undergo a process of system consolidation during sleep. Whereas older research concentrated on the role of rapid-eye-movement (REM) sleep, recent work has revealed the importance of slow-wave sleep (SWS) for memory consolidation and also enlightened some of the underlying electrophysiological, neurochemical, and genetic mechanisms, as well as developmental aspects in these processes. Specifically, newer findings characterize sleep as a brain state optimizing memory consolidation, in opposition to the waking brain being optimized for encoding of memories. Consolidation originates from reactivation of recently encoded neuronal memory representations, which occur during SWS and transform respective representations for integration into long-term memory. Ensuing REM sleep may stabilize transformed memories. While elaborated with respect to hippocampus-dependent memories, the concept of an active redistribution of memory representations from networks serving as temporary store into long-term stores might hold also for non-hippocampus-dependent memory, and even for nonneuronal, i.e., immunological memories, giving rise to the idea that the offline consolidation of memory during sleep represents a principle of long-term memory formation established in quite different physiological systems.

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Section: B Rem Sleep and Memory Consolidationmentioning

confidence: 99%

About Sleep's Role in Memory

Rasch

Born

2013

Physiological Reviews

2,270

2,026

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“…2B, arrows in first panel). Finally, such changes would be transcriptionally stored during REM sleep by way of CREBdependent gene expression (Ribeiro et al 1999(Ribeiro et al , 2002, able to trigger plasticity-related protein synthesis (Gutwein et al 1980;Thiel et al 1994;Petersohn et al 1995) and hence consolidate newly acquired memory traces in the following hours (Fig. 4A).…”

Section: A Model For the Complementary Roles Of Sw And Rem Sleep In Mmentioning

confidence: 99%

“…The persistence of increased neuronal activity immediately after a stimulus is a widespread phenomenon that likely arises from hardwired neuronal circuit loops (Lorente de Nó 1938) but also, and more pertinent to the issue of learning, from pregenomic biochemical changes (Wang 2001) able to cause activitydependent synaptic modification and long-lasting learning via de novo protein synthesis (Agranoff et al 1966;Bliss and Collingridge 1993;Lamprecht and LeDoux 2004). The two pioneering studies (Gutwein et al 1980;Pavlides and Winson 1989) suggested that sleep harbored both mechanisms postulated by Donald Hebb to be necessary and sufficient to explain memory consolidation: postacquisition neuronal reverberation, and structural synaptic plasticity (Hebb 1949). …”

mentioning

confidence: 99%

“…The chase for the mechanisms underlying the mnemonic role of sleep produced two major spearheading findings: (1) neuronal firing rates observed during waking (WK) experience recur in the hippocampus during ensuing SW and REM sleep (Pavlides and Winson 1989), and (2) the blockade of protein synthesis during sleep impairs memory acquisition (Gutwein et al 1980). The persistence of increased neuronal activity immediately after a stimulus is a widespread phenomenon that likely arises from hardwired neuronal circuit loops (Lorente de Nó 1938) but also, and more pertinent to the issue of learning, from pregenomic biochemical changes (Wang 2001) able to cause activitydependent synaptic modification and long-lasting learning via de novo protein synthesis (Agranoff et al 1966;Bliss and Collingridge 1993;Lamprecht and LeDoux 2004).…”

mentioning

confidence: 99%

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Reverberation, storage, and postsynaptic propagation of memories during sleep

Ribeiro¹,

Nicolelis²

2004

Learn. Mem.

131

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In mammals and birds, long episodes of nondreaming sleep ("slow-wave" sleep, SW) are followed by short episodes of dreaming sleep ("rapid-eye-movement" sleep, REM). Both SW and REM sleep have been shown to be important for the consolidation of newly acquired memories, but the underlying mechanisms remain elusive. Here we review electrophysiological and molecular data suggesting that SW and REM sleep play distinct and complementary roles on memory consolidation: While postacquisition neuronal reverberation depends mainly on SW sleep episodes, transcriptional events able to promote long-lasting memory storage are only triggered during ensuing REM sleep. We also discuss evidence that the wake-sleep cycle promotes a postsynaptic propagation of memory traces away from the neural sites responsible for initial encoding. Taken together, our results suggest that basic molecular and cellular mechanisms underlie the reverberation, storage, and propagation of memory traces during sleep. We propose that these three processes alone may account for several important properties of memory consolidation over time, such as deeper memory encoding within the cerebral cortex, incremental learning several nights after memory acquisition, and progressive hippocampal disengagement.In mammals and birds, long episodes of nondreaming sleep ("slow-wave" sleep, SW) are followed by short episodes of dreaming sleep ("rapid-eye-movement" sleep, REM) (Aserinsky and Kleitman 1953; Dement and Kleitman 1957a,b;Dement 1958;Jouvet et al. 1959;Roffwarg et al. 1962;Tradardi 1966;Jouvet 1967;Rechtschaffen and Kales 1968;Ayala-Guerrero et al. 2003). Despite early insight (Jenkins and Dallenbach 1924), it was not until the 1970s that science began to recognize the key role of sleep in memory consolidation. The main findings supporting this view are the detrimental effects of sleep deprivation on learning (Pearlman 1969(Pearlman , 1973Leconte and Bloch 1970;Fishbein 1971;Pearlman and Becker 1974;Linden et al. 1975;Shiromani et al. 1979;Smith and Butler 1982;Smith and Kelly 1988;Smith and MacNeill 1993;Karni et al. 1994;Smith and Rose 1996;Stickgold et al. 2000a;Walker et al. 2002;Maquet et al. 2003;Mednick et al. 2003), the improved memory retention in rats when REM sleep is enhanced (Wetzel et al. 2003), the increase in sleep amounts following memory acquisition (Lucero 1970;Leconte and Hennevin 1971;Fishbein et al. 1974;Smith et al. 1974Smith et al. , 1980Smith andLapp 1986, 1991;Smith and Wong 1991), and the fact that theta rhythm, a learning-related (Adey et al. 1960;Elazar and Adey 1967;Landfield et al. 1972;Bennett 1973;Bennett et al. 1973;Winson 1978;Sederberg et al. 2003) hippocampal oscillation typical of high arousal (Green and Arduini 1954;Brown 1968;Sainsbury 1970;Harper 1971;Arnolds et al. 1980;Stewart and Fox 1991;Kahana et al. 1999), also characterizes REM sleep (Vanderwolf 1969;Timo-Iaria et al. 1970;Winson 1974;Cantero et al. 2003). Given the involvement of the hippocampus in memory acquisition (Scoville and Milner 1957;Mishkin 1978;Kesner...

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“…18 Dado o envolvimento do hipocampo na aquisição de memórias, [19][20][21] estes resultados sugeriram que o sono facilita o processamento de novas de informações. [22][23][24] A investigação dos mecanismos subjacentes ao papel mnemônico do sono levou a dois resultados importantes: 1) o bloqueio de síntese protéica durante o sono danifica a aquisição de memórias, 25 e 2) padrões de atividade neuronal relacionados às experiências da vigília reaparecem no hipocampo durante o sono. 26 Tendo em vista que o aprendizado duradouro requer modificações sinápticas dependentes de atividade neuronal e de síntese protéica de novo, 27,28 sugere-se que o sono abriga ambos os mecanismos postulados por Hebb 29 como necessári-os e suficientes para explicar a consolidação de memórias: reativação neuronal pós-estímulo ('reverberação') e plasticidade sináptica ('mudança estrutural').…”

Section: Sono E Memóriaunclassified

Sonho, memória e o reencontro de Freud com o cérebro

Ribeiro

2003

Rev. Bras. Psiquiatr.

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Para que serve sonhar? A vasta contribuição sobre a função dos sonhos dada por Freud e Jung foi em grande parte ignorada pela ciência, pela falta de um método quantitativo e de hipóteses testáveis. Não obstante, vários resultados experimentais corroboram dois importantes "insights" psicanalíticos: 1) que os sonhos freqüentemente contêm elementos da experiência do dia anterior, denominados de "restos do dia", e 2) que estes "restos" incluem atividades mnemônicas, levando portanto a uma facilitação do aprendizado. Em particular, dados recentes sugerem que os sonhos podem desempenhar um papel essencial na consolidação das memórias, levando aquelas recentemente adquiridas a migrar do hipocampo para o neocórtex. (Konrad Lorenz, 1948).Para que serve sonhar? No início do século XX esta pergunta ancestral pareceu subitamente ao alcance da Razão, com a publicação de "A Interpretação dos sonhos".1 Neste livro Freud fundou uma nova e ambiciosa psicologia, repleta de novas idéi-as sobre a mente humana e seus sonhos. A despeito do impacto profundo destas idéias na sociedade ocidental, sua formulação 1 e desenvolvimento 2,3 não se deram sobre uma base empírica e quantitativa, marcando um divórcio progressivo de método e discurso entre a psicanálise e a biologia. Como resultado, pouca ou nenhuma influência é atualmente atribuída a Freud no que diz respeito à investigação científica do fenômeno onírico.O fosso não poderia ser mais profundo. Predomina nas ciên-cias exatas a noção de que a contribuição da psicanálise para o entendimento dos sonhos resume-se a um amontoado de observações isoladas, teorias não-testáveis, imperativos ideoló-gicos e argumentos de autoridade. Por outro lado, as diferentes vertentes da psicanálise ocupam-se pouco ou nada do estudo

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Paradoxical sleep and memory: Long-term disruptive effects of anisomycin

Cited by 32 publications

References 22 publications

About Sleep's Role in Memory

About Sleep's Role in Memory

Reverberation, storage, and postsynaptic propagation of memories during sleep

Sonho, memória e o reencontro de Freud com o cérebro

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