Paradoxical sleep deprivation of the mother enhances DNA synthesis in fetal rat brain: Autoradiographic and biochemical evidence

Zucconi, G; Belia, Silvia; Menichini, E.; Castigli, Emilia; Giuditta, Antonio

doi:10.1016/0736-5748(86)90042-0

Cited by 5 publications

(1 citation statement)

References 13 publications

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“…Some kind of connection might only be envisaged in the framework of a Lamarckian mechanism of brain evolution (Barry, 2013 ). While such questions are likely to remain without suitable answers for some time, it may still be worth noting that deprivation of active sleep in fetal rats induces a marked increment in brain DNA synthesis (Grassi Zucconi et al, 1986 ).…”

Section: Comparing Shy With Shmentioning

confidence: 99%

Sleep memory processing: the sequential hypothesis

Giuditta

2014

Front. Syst. Neurosci.

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According to the sequential hypothesis (SH) memories acquired during wakefulness are processed during sleep in two serial steps respectively occurring during slow wave sleep (SWS) and rapid eye movement (REM) sleep. During SWS memories to be retained are distinguished from irrelevant or competing traces that undergo downgrading or elimination. Processed memories are stored again during REM sleep which integrates them with preexisting memories. The hypothesis received support from a wealth of EEG, behavioral, and biochemical analyses of trained rats. Further evidence was provided by independent studies of human subjects. SH basic premises, data, and interpretations have been compared with corresponding viewpoints of the synaptic homeostatic hypothesis (SHY). Their similarities and differences are presented and discussed within the framework of sleep processing operations. SHY’s emphasis on synaptic renormalization during SWS is acknowledged to underline a key sleep effect, but this cannot marginalize sleep’s main role in selecting memories to be retained from downgrading traces, and in their integration with preexisting memories. In addition, SHY’s synaptic renormalization raises an unsolved dilemma that clashes with the accepted memory storage mechanism exclusively based on modifications of synaptic strength. This difficulty may be bypassed by the assumption that SWS-processed memories are stored again by REM sleep in brain subnuclear quantum particles. Storing of memories in quantum particles may also occur in other vigilance states. Hints are provided on ways to subject the quantum hypothesis to experimental tests.

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Section: Comparing Shy With Shmentioning

confidence: 99%