Parafascicular thalamic nucleus deep brain stimulation decreases NMDA receptor GluN1 subunit gene expression in the prefrontal cortex

Fernández-Cabrera, Mónica R.; Selvas, Abraham; Miguéns, Miguel; Higuera-Matas, Alejandro; Vale-Martínez, Anna; Ambrosio, Emilio; Martí-Nicolovius, Margarita; Guillazo-Blanch, Gemma

doi:10.1016/j.neuroscience.2017.02.009

Cited by 7 publications

(3 citation statements)

References 71 publications

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“…The neuromodulation of CM-Pf complex using deep brain stimulation for Tourette’s syndrome is also an emerging target for treatment 125 . The DBS of Pf may modulate cognitive functions by inducing molecular-level gene expression changes in the prefrontal cortex 126 . The sPf stimulations show dopamine release modulation in the inferior colliculus of rats and are suggested to be involved in the auditory processing deficits associated with Parkinson's 127 .…”

Section: Discussionmentioning

confidence: 99%

The structural connectivity mapping of the intralaminar thalamic nuclei

Kumar

Scheffler

Grodd

2023

Sci Rep

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The intralaminar nuclei of the thalamus play a pivotal role in awareness, conscious experience, arousal, sleep, vigilance, as well as in cognitive, sensory, and sexual processing. Nonetheless, in humans, little is known about the direct involvement of these nuclei in such multifaceted functions and their structural connections in the brain. Thus, examining the versatility of structural connectivity of the intralaminar nuclei with the rest of the brain seems reasonable. Herein, we attempt to show the direct structural connectivity of the intralaminar nuclei to diencephalic, mesencephalic, and cortical areas using probabilistic tracking of the diffusion data from the human connectome project. The intralaminar nuclei fiber distributions span a wide range of subcortical and cortical areas. Moreover, the central medial and parafascicular nucleus reveal similar connectivity to the temporal, visual, and frontal cortices with only slight variability. The central lateral nucleus displays a refined projection to the superior colliculus and fornix. The centromedian nucleus seems to be an essential component of the subcortical somatosensory system, as it mainly displays connectivity via the medial and superior cerebellar peduncle to the brainstem and the cerebellar lobules. The subparafascicular nucleus projects to the somatosensory processing areas. It is interesting to note that all intralaminar nuclei have connections to the brainstem. In brief, the structural connectivity of the intralaminar nuclei aligns with the structural core of various functional demands for arousal, emotion, cognition, sensory, vision, and motor processing. This study sheds light on our understanding of the structural connectivity of the intralaminar nuclei with cortical and subcortical structures, which is of great interest to a broader audience in clinical and neuroscience research.

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Section: Discussionmentioning

confidence: 99%

The structural connectivity mapping of the intralaminar thalamic nuclei

Kumar

Scheffler

Grodd

2023

Sci Rep

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“… 54 , 67 For instance, Nanda et al 68 showed that CM-DBS raises GABA levels in the striatum of awake rhesus monkeys. Furthermore, Fernández-Cabrera et al 69 showed that CM-DBS lowers pathological levels of glutamatergic activity in the prefrontal cortex in rats.…”

Section: The Intralaminar Thalamus As Target In Epilepsymentioning

confidence: 99%

The intralaminar thalamus: a review of its role as a target in functional neurosurgery

Arnts

Coolen

Fernandes

et al. 2023

Brain Communications

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The intralaminar thalamus, in particular the centromedian-parafascicular complex, forms a strategic node between ascending information from the spinal cord and brainstem and forebrain circuitry that involves the cerebral cortex and basal ganglia. A large body of evidence shows that this functionally heterogeneous region regulates information transmission in different cortical circuits, and is involved in a variety of functions, including cognition, arousal, consciousness, and processing of pain signals. Not surprisingly, the intralaminar thalamus has been a target area for (radio)surgical ablation and deep brain stimulation in different neurological and psychiatric disorders. Historically, ablation and stimulation of the intralaminar thalamus have been explored in patients with pain, epilepsy, and Tourette syndrome. Moreover, deep brain stimulation has been used as an experimental treatment for disorders of consciousness and a variety of movement disorders. In this review, we provide a comprehensive analysis of the underlying mechanisms of stimulation and ablation of the intralaminar nuclei, historical clinical evidence, and more recent (experimental) studies in animals and humans to define the present and future role of the intralaminar thalamus as a target in the treatment of neurological and psychiatric disorders.

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“…Recently, DBS of the parafascicular thalamic nucleus has shown to affect NMDA receptor GluN1 subunit gene expression in the prefrontal cortex. [ 6 ] In this study, 20 naïve Wistar rats were stimulated for 20 min at 1 Hz cathodic square pulse trains of 500 ms and a current intensity ranging from 60 to 100 μA depending on the rats’ behavior (agitation, motor stereotypies, or other abnormal behavior were avoided). The results showed that parafascicular thalamic nucleus DBS induced a decrease in NMDAR GluN1 subunit gene expression in the cingulate and prelimbic cortices, but no significant differences were found in the density of NMDA or GABAB receptors.…”

Section: Preclinical Studiesmentioning

confidence: 99%

Deep brain stimulation for Alzheimer's Disease: An update

Aldehri¹,

Temel²,

Alnaami³

et al. 2018

Surg Neurol Int

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Background:Dementia is among the leading causes of severe and long-term disability worldwide, decreasing the quality of life of individuals and families. Moreover, it induces an enormous economic burden on societies. The most prevalent cause of dementia is Alzheimer's disease (AD). Because current treatment options for AD are limited, deep brain stimulation (DBS) has been considered.Methods:The aim of this review is to survey the current understanding regarding the effects of DBS in AD and possibly shed light on the mechanisms of DBS in AD. We searched PubMed and Cochrane for various studies in English literature describing DBS in patients with AD and relevant preclinical studies. All related studies published from December 2013 to March 2017 were included in this review.Results:Our understanding of the neural circuitry underlying learning and memory in both rodent models and human patients has grown over the past years and provided potential therapeutic targets for DBS such as the fornix and the nucleus basalis of Meynert. Clinical results indicate that DBS is most beneficial for patients who are in the early stages of AD. Potential mechanisms of action of DBS in AD comprise long-term structural plasticity, including hippocampal enlargement as well as enhanced neurotransmitter release.Conclusion:It is still premature to conclude that DBS can be used in the treatment of AD, and the field will wait for the results of ongoing and future clinical trials.

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Parafascicular thalamic nucleus deep brain stimulation decreases NMDA receptor GluN1 subunit gene expression in the prefrontal cortex

Cited by 7 publications

References 71 publications

The structural connectivity mapping of the intralaminar thalamic nuclei

The structural connectivity mapping of the intralaminar thalamic nuclei

The intralaminar thalamus: a review of its role as a target in functional neurosurgery

Deep brain stimulation for Alzheimer's Disease: An update

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