Paraganglioma laríngeo, diagnóstico y tratamiento. Apropósito de un caso

Rubio, Vladimir; Tamarit, José Manuel; Baviera, Nuria; Estrems, Paloma; López, C.; Estellés, Enrique; Dalmau, José

doi:10.1016/s0001-6519(07)74939-7

Cited by 5 publications

(6 citation statements)

References 5 publications

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“…In laryngeal paragangliomas, the symptoms depend on the location of the tumor, which generally includes dysphonia, dysphagia, stridor, or a foreign body sensation. Although these tumors occur in a wide variety of anatomical locations, computed tomography (CT) images have almost identical characteristics, such as soft-tissue masses with well-defined contours with homogeneous or heterogeneous enhancement in the presence of necrosis and hemorrhage 1,7 and in the case of Laryngeal paragangliomas, a laryngoscopy is essential.…”

Section: Clinic and Diagnosismentioning

confidence: 99%

“…Laboratory tests can aid detection by determining catecholamines and their metabolites in plasma and urine; vanilmandelic acid will be twice above the normal value (VN: 2-10 mg/24 h); urinary and serum norepinephrine will be eight times the normal value > 2,000 Pg/ml; chromogranin at levels of 111 ng/ml (VN: 143 ng/ml) 1 . Arteriography is useful to define the tumor extension, the mass effect, the proximity to important vessels, and the degree of collateral circulation for the purpose of meticulous surgical planning 7 , so in the presence of hypervascular masses, the possibility of a paraganglioma should always be considered also considering the autosomal dominant character when having a family history of paraganglioma 1 . Radionucleotide techniques (indium-labeled pentetreotide or iodomethabenzylguanidine) are reserved in cases of diagnostic doubt, follow-up, and synchronous lesions 7 .…”

Section: Clinic and Diagnosismentioning

confidence: 99%

“…Arteriography is useful to define the tumor extension, the mass effect, the proximity to important vessels, and the degree of collateral circulation for the purpose of meticulous surgical planning 7 , so in the presence of hypervascular masses, the possibility of a paraganglioma should always be considered also considering the autosomal dominant character when having a family history of paraganglioma 1 . Radionucleotide techniques (indium-labeled pentetreotide or iodomethabenzylguanidine) are reserved in cases of diagnostic doubt, follow-up, and synchronous lesions 7 . Octreotide examination can further confirm the diagnosis, and urine collection of catecholamines and metanephrines can identify vasoactive secretory tumors.…”

Section: Clinic and Diagnosismentioning

confidence: 99%

“…Octreotide examination can further confirm the diagnosis, and urine collection of catecholamines and metanephrines can identify vasoactive secretory tumors. As a complementary test, fine-needle aspiration-puncture is a controversial indication technique; classically, it has been contraindicated due to the risk of bleeding 7 , although with endolaryngeal microsurgical methods, it can be considered with greater safety in case of suspected malignancy.…”

Section: Clinic and Diagnosismentioning

confidence: 99%

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Laryngeal paraganglioma: A case report

Santana-Hernández¹,

Monroy-Romero²,

Guillén-Montiel³

et al. 2022

GAMO

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Paragangliomas correspond to tumors of neuroendocrine origin of chromaffin cells in the paraganglia of the sympathetic or parasympathetic nervous system, particularly those located in the larynx being extremely rare, contributing to < 0.6% of laryngeal tumors. Most are sporadic, although 40% may have a familial occurrence. Symptoms depend on size, generally including dysphonia, dysphagia, or a foreign body sensation. The diagnosis is established by laryngoscopy and CT, observing soft-tissue masses with well-defined contours, coupled with histological confirmation by the presence of stem cells in a "Zell Balen" configuration, and immunohistochemistry with chromogranin and S100 protein.

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Section: Clinic and Diagnosismentioning

confidence: 99%

Section: Clinic and Diagnosismentioning

confidence: 99%

Section: Clinic and Diagnosismentioning

confidence: 99%

Section: Clinic and Diagnosismentioning

confidence: 99%

See 2 more Smart Citations

Laryngeal paraganglioma: A case report

Santana-Hernández¹,

Monroy-Romero²,

Guillén-Montiel³

et al. 2022

GAMO

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“…hemoptisis, solo 3% son secretores y 3% multicéntricos generalmente asociados a paragangliomas carotídeo (1,2,3).…”

Section: Introductionunclassified

Paragangliomas laríngeos: Comparación de su abordaje por faringotomía lateral y por laringofisura en dos casos.

Hernández¹,

Calleros²,

Hernández³

2017

Acta otorrinolaringol cir cabeza cuello

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Los paragangliomas son las neoplasias vasculares benignas más comunes del cuello. Surgen de células paragangliónicas extraadrenales derivadas de la cresta neural. El 90% se presentan en el tejido adrenal y 10% en tejidos extraadrenales de los cuales el 85% son abdominales, 12% torácicos y 3% en cabeza y cuello. El sitio más común de presentación es el cuerpo carotídeo, seguido por yugulotimpánicos y vagales. Otros sitios infrecuentes incluyen laringe, cavidad nasal, órbita, tráquea, cuerpo aórtico y mediastino. Se presentan los casos de dos pacientes con paragangliomas laríngeos en quienes se realizó faringotomía lateral y laringofisura, para connotar la importancia de tener presentes los diagnósticos diferenciales ante el hallazgo de una masa supraglótica y plantear un flujograma diagnóstico y terapéutico.

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Neuroendocrine neoplasms of the larynx: An overview

et al. 2009

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Neuroendocrine neoplasms of the larynx are rare but are the most common nonsquamous tumors of this organ. In the past, there has been considerable confusion about the nature and classification of these neoplasms, but the current consensus is that there are 4 different types of laryngeal neuroendocrine tumors composed of paraganglioma, typical carcinoid, atypical carcinoid tumor, and small cell neuroendocrine carcinoma. Carcinoids and small cell neuroendocrine carcinomas are epithelial neoplasms, whereas paragangliomas are of neural origin. Diagnosis is based primarily on light microscopy and confirmed by immunohistochemistry and electron microscopy. Precise diagnosis is essential because the natural history, treatment, and prognosis vary widely for the different neoplastic categories. Typical carcinoids are very rare and are treated by wide local excision, usually partial laryngectomy, without elective neck dissection. Atypical carcinoid tumors are more common and more aggressive. They are treated by partial or total laryngectomy with elective or therapeutic neck dissection. Adjuvant chemo/radiotherapy may be of benefit in some cases. Small cell neuroendocrine carcinomas are highly aggressive and should be considered disseminated at initial diagnosis. The treatment is by irradiation and chemotherapy as surgery has proven to be of a little benefit. Paragangliomas are treated by local excision or partial laryngectomy. It is difficult to determine the valid survival statistics for typical carcinoids because of their rarity and confusion in the literature with their atypical counterparts. They have a greater tendency to metastasize, and thus a worse prognosis than was previously believed. Atypical carcinoid tumors have a 5-year survival rate of approximately 50%, which decreases with time. The prognosis of small cell neuroendocrine carcinoma of the larynx is dismal, with 5-year survival rates of 5%. The biological behavior of laryngeal paraganglioma is generally benign and the prognosis is excellent.

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Paraganglioma laríngeo, diagnóstico y tratamiento. Apropósito de un caso

Cited by 5 publications

References 5 publications

Laryngeal paraganglioma: A case report

Laryngeal paraganglioma: A case report

Paragangliomas laríngeos: Comparación de su abordaje por faringotomía lateral y por laringofisura en dos casos.

Neuroendocrine neoplasms of the larynx: An overview

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