Paraganglioma of the Recurrent Laryngeal Nerve

Dougherty, Thomas J.; Aitken, Gabriela L.; Harrell, R. Mack; Edwards, Carol C.; González, Silvana Guerrero; Bimston, David N.

doi:10.1016/j.aace.2023.07.002

Cited by 3 publications

(1 citation statement)

References 8 publications

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“…The most common locations for head and neck paragangliomas are the carotid body, glossopharyngeal or vagus nerves, and the jugular bulb [3,4]. However, there have only been three reports in the literature of a paraganglioma arising from the recurrent laryngeal nerve [4][5][6]. Thus, we present the fourth known case.…”

Section: Introductionmentioning

confidence: 98%

Paraganglioma of the Right Recurrent Laryngeal Nerve Presenting as a Thyroid Nodule

Raymond,

Peebles,

Diaz

et al. 2024

Cureus

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Paragangliomas are abnormal growth cells of neuroectodermal origin that arise from the autonomic nervous system. Head and neck paragangliomas are rare, commonly benign and often have a hereditary origin. Head and neck paragangliomas most commonly arise in the carotid bodies, vagus and glossopharyngeal nerves, and the sympathetic chain. However, we present a case of a paraganglioma arising from the recurrent laryngeal nerve, a phenomenon that has been reported only three times before in the literature. The patient is a 49-year-old female with a past medical history of bilateral carotid body paragangliomas and Hashimoto’s disease. She has a family history of paragangliomas in her father and distant relatives and carries a pathogenic variation in the succinate-dehydrogenate subunit D ( SDHD ) gene, which was first identified through the original linkage studies involving her family. She presented with a mild swelling sensation in her neck. A thyroid ultrasound revealed a right lobe nodule measuring 3.3 x 2.2 x 2.1 cm. Fine needle aspiration of the nodule revealed an atypia of undetermined significance with a risk of malignancy judged as 50%. A total thyroidectomy was performed due to concern for malignancy. During the operation, the thyroid was nodular and hypervascular. At the right thyroid lobe, there was a pearlescent tubular structure approximately 4-5 mm in size. This was stimulated via intraoperative nerve monitoring and was consistent with being a part of the right recurrent laryngeal nerve. Pathology of the tubular structure revealed a 2.8 cm paraganglioma of the right recurrent laryngeal nerve. An incidental 0.1 cm papillary thyroid microcarcinoma within the left thyroid lobe was also noted. Our patient presented with a history of paragangliomas at a very young age and bilaterality, features that are highly characteristic of hereditary disease. Through the original linkage studies involving her family, her father was recognized as being an obligate carrier at risk of bearing occult paragangliomas. Imaging showed that he carried three paragangliomas. Identification of the familial SDHD syndrome as well as SDHD testing has now become widely available. Recognizing hereditary paraganglioma and other cancer susceptibility syndromes can help foster more knowledge on the subject and improve clinical outcomes. More attention should be put on the presentation of paragangliomas in an atypical location, such as in our case.

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Section: Introductionmentioning

confidence: 98%

Paraganglioma of the Right Recurrent Laryngeal Nerve Presenting as a Thyroid Nodule

Raymond,

Peebles,

Diaz

et al. 2024

Cureus

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Editorial for Jan/Feb Issue of AACE Clinical Case Reports

Jasim

2024

AACE Clinical Case Reports

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Medical conditions associated with concurrent dysphagia and dysphonia

Myszel,

Henryk Skarzynski

2024

Swallowing - Problems and Management [Working Title]

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Swallowing and voice production are important processes enabling a comfortable life. For appropriate alimentation, effective passage of food and fluids through a digestive system is necessary. Interpersonal communication depends on good voice and speech. Conditions associated with swallowing and speech problems leads dysfunctions and seriously affect the patient’s comfort of living. This chapter is a review of medical conditions associated with concurrence of dysphonia and dysphagia. There are a large number of medical conditions leading to the simultaneous occurrence of swallowing problems and hoarseness. The diversity of disorders is a serious interdisciplinary issue. Diagnostics of concurrent dysphagia and dysphonia is complicated and requires a holistic interdisciplinary approach. The reasons include functional and organic dysfunctions, neurological conditions, tumors, vascular disorders, autoimmune inflammations, post-operative complications, post-COVID complications, and others. Our research was conducted by reviewing PubMed and Scopus network using key words “dysphagia”, “dysphonia”, “hoarseness.” We found 966 publications, then narrowed the search to 99 articles describing medical conditions and case reports, which present with dysphagia and dysphonia occurring together. Detailed analysis enabled us to categorize the disorders into groups, depending on characteristics and body region involved in the pathological process. Finally, the description of the medical conditions was done systematically according to those groups.

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Paraganglioma of the Recurrent Laryngeal Nerve

Cited by 3 publications

References 8 publications

Paraganglioma of the Right Recurrent Laryngeal Nerve Presenting as a Thyroid Nodule

Paraganglioma of the Right Recurrent Laryngeal Nerve Presenting as a Thyroid Nodule

Editorial for Jan/Feb Issue of AACE Clinical Case Reports

Medical conditions associated with concurrent dysphagia and dysphonia

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