Paraganglioma of the sphenoid sinus: case report and review of literature

Morales, Humberto; Castillo, Maurício; Jewells, Valerie

doi:10.1016/j.clinimag.2006.10.001

Cited by 14 publications

(11 citation statements)

References 36 publications

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“…In our experience, SPs have more eosinophilic cytoplasm; they show ''tighter'' nesting without intervening stroma and are more common in the nasal cavity and sinuses than the cribriform plate. [47][48][49] In our opinion, these 2 diagnoses should be made with caution and reserved for large biopsies or resections.…”

Section: Other Rare Mimicsmentioning

confidence: 99%

Olfactory Neuroblastoma

Faragalla

Weinreb²

2009

Advances in Anatomic Pathology

113

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Olfactory neuroblastoma (ONB) is a malignant neuroectodermal tumor that typically occurs in the superior nasal cavity. It is a distinct entity with features that include nesting, low-grade stippled nuclei, and neurofibrillary stroma with formation of pseudorosettes. It has a distinctive immunoprofile that includes keratin negativity, neuroendocrine marker positivity, and S100 positive sustentacular cells, which surround the nests of tumor in a supportive manner. Although the typical clinicopathologic features leave little room for misinterpretation, the wide variability in this tumor may cause diagnostic difficulty. This includes immunophenotypic diversity or patchy staining with immunomarkers, wide spectrum of grade and histology, posttreatment changes, and occasional divergent differentiation. In addition, problems in sampling, preservation, and clinical localization may make the diagnosis more challenging. A large group of tumors may show morphologic overlap with ONB, with some mimicking low-grade tumors, whereas others mimic high-grade tumors. This differential diagnosis has important treatment and prognostic implications. Further complicating the issue is that many of the mimics themselves may show great morphologic and immunophenotypic variability. This manuscript will review the typical clinical and pathologic features of ONB, address the great variability of ONB in our experience, will focus on the differential diagnosis and report on recent findings in these tumors including molecular genetics where applicable.

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Section: Other Rare Mimicsmentioning

confidence: 99%

Olfactory Neuroblastoma

Faragalla

Weinreb²

2009

Advances in Anatomic Pathology

113

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“…The findings in the current analysis were similar, with the most common initial presenting symptoms being nasal obstruction (53.7%) and recurrent epistaxis (68.5%). Occasionally, patients may present with functioning sinonasal paragangliomas, resulting in symptoms of Cushing's syndrome and hypertension . Thomas et al .…”

Section: Discussionmentioning

confidence: 99%

Characteristics and management of sinonasal paragangliomas: a systematic review

Nguyen

Patel

Arianpour

et al. 2018

Int Forum Allergy Rhinol

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Background: Paragangliomas of the nasal cavity and paranasal sinuses, although exceedingly rare, can exhibit frequent and aggressive recurrences. Our objective was to evaluate tumor characteristics, clinical course, management, and associated complications of sinonasal paragangliomas Methods: A systematic review of the literature was performed utilizing the Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA) guidelines, searching for sinonasal paraganglioma. Studies meeting inclusion criteria were assessed for level of evidence. Patient demographics, tumor characteristics, primary intervention, and other clinical characteristics were evaluated.Results: Forty-five relevant studies encompassing 54 patients with sinonasal paraganglioma were identified. The most common tumor locations were the nasal cavity (66.7%), ethmoid sinuses (22.2%), maxillary sinuses (7.4%), and sphenoid sinuses (3.7%). Common presenting symptoms included recurrent epistaxis (68.5%), nasal obstruction (53.7%), and headache (13.0%). Tumors were malignant in 28.6% of patients. Only 4 cases (7.4%) involved functional tumors. Initial management was always surgical, via either an open (63.0%) or endoscopic (33.3%) approach. Radiotherapy was used as adjunctive treatment in 10 cases (18.5%). Recurrence rate was 21.7% and occurred between 12 to 156 months a er initial resection. The overall survival was 87.0% with a metastatic rate of 8.7%. Conclusion:Sinonasal paragangliomas are vascular neoplasms manifesting clinically with recurrent epistaxis and nasal obstruction. Management goals are total resection with clear margins and long-term follow-up due to tendency for local recurrence. Radiotherapy has been utilized as adjuvant therapy with variable results. Further randomized controlled studies may be invaluable in elucidating these findings. C 2018 ARS-AAOA, LLC.

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“…The lack of intervening fibrovas cularstroma and tumor location helps to differentiate the two entities. 24 - 26 …”

Section: Discussionmentioning

confidence: 99%

Olfactory neuroblastoma: A clinicopathological experience of a rare entity from Pakistan

et al. 2016

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Objectives:To present the clinicopathological experience of Olfactory Neuroblastoma (ONB) with emphasis on histopathological and immunohistochemical features.Methods:A descriptive cross-sectional study was done on 36 cases of ONB, selected by non-probability purposive sampling. Theses cases of ONB were retrieved and reviewed from surgical pathology database of Aga Khan University Hospital reported between January 1993 and March 2015.Results:Tumor size and age of presentation was wide in range without any distinct bimodal distribution. Nasal cavity was most common site along with involvement of paranasal sinuses. More than 50% cases had Kadish stage A. Microscopically, most cases were Grade-1 and majority showed partial or complete lobular architecture. Neurofibrillary matrix was observed in 2/3rd of cases. Among immunohistochemical markers, Neuron Specific Enolase was most frequently expressed. Unusual positive expression of Cytokeratin AE1/AE3 and Cytokeratin CAM5.2 was also seen focally in few cases.Conclusion:The ONB has great variability of histological and clinical presentation, and immunohistochemical markers are useful to differentiate from more common small round blue cell tumours of nasal cavity.

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Paraganglioma of the sphenoid sinus: case report and review of literature

Cited by 14 publications

References 36 publications

Olfactory Neuroblastoma

Olfactory Neuroblastoma

Characteristics and management of sinonasal paragangliomas: a systematic review

Olfactory neuroblastoma: A clinicopathological experience of a rare entity from Pakistan

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