Paraganglioma of the Urinary Bladder: A Case Report and Review of the Japanese Literature

Shono, Takefumi; Sakai, Hideki; Minami, Yuzo; Suzu, H; Kanetake, Hiroshi; Saito, Yutaka

doi:10.1159/000030367

Cited by 14 publications

(5 citation statements)

References 5 publications

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“…Recently, vanillylmandelic acid is gaining increasing attention due to its potential to diagnose pheochromocytoma 42 and paraganglioma of the bladder. 43 Elevated vanillylmandelic acid in urine of BC patients observed in our study was also consistent with its higher urinary level in patients with paraganglioma of the bladder. 43,44 It was observed that concentration of vanillylmandelic acid returns to normal in 1 year after complete removal of the tumor in paraganglioma patients.…”

Section: ■ Discussionsupporting

confidence: 89%

“…43 Elevated vanillylmandelic acid in urine of BC patients observed in our study was also consistent with its higher urinary level in patients with paraganglioma of the bladder. 43,44 It was observed that concentration of vanillylmandelic acid returns to normal in 1 year after complete removal of the tumor in paraganglioma patients. 45 In addition, the urinary levels of uridine and pseudouridine, endogenous metabolites for the synthesis of RNA, were found to be higher in BC compared to non-BC urine, reflecting the higher energetic state of the tumor.…”

Section: ■ Discussionsupporting

confidence: 89%

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Urinary Metabotyping of Bladder Cancer Using Two-Dimensional Gas Chromatography Time-of-Flight Mass Spectrometry

et al. 2013

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Cystoscopy is the gold standard clinical diagnosis of human bladder cancer (BC). As cystoscopy is expensive and invasive, it compromises patients' compliance toward surveillance screening and challenges the detection of recurrent BC. Therefore, the development of a noninvasive method for the diagnosis and surveillance of BC and the elucidation of BC progression become pertinent. In this study, urine samples from 38 BC patients and 61 non-BC controls were subjected to urinary metabotyping using two-dimensional gas chromatography time-of-flight mass spectrometry (GC×GC-TOFMS). Subsequent to data preprocessing and chemometric analysis, the orthogonal partial least-squares discriminant analysis (OPLS-DA, R2X=0.278, R2Y=0.904 and Q2Y (cumulative)=0.398) model was validated using permutation tests and receiver operating characteristic (ROC) analysis. Marker metabolites were further screened from the OPLS-DA model using statistical tests. GC×GC-TOFMS urinary metabotyping demonstrated 100% specificity and 71% sensitivity in detecting BC, while 100% specificity and 46% sensitivity were observed via cytology. In addition, the model revealed 46 metabolites that characterize human BC. Among the perturbed metabolic pathways, our clinical finding on the alteration of the tryptophan-quinolinic metabolic axis in BC suggested the potential roles of kynurenine in the malignancy and therapy of BC. In conclusion, global urinary metabotyping holds potential for the noninvasive diagnosis and surveillance of BC in clinics. In addition, perturbed metabolic pathways gleaned from urinary metabotyping shed new and established insights on the biology of human BC.

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Section: ■ Discussionsupporting

confidence: 89%

Section: ■ Discussionsupporting

confidence: 89%

Urinary Metabotyping of Bladder Cancer Using Two-Dimensional Gas Chromatography Time-of-Flight Mass Spectrometry

et al. 2013

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“…14 In the analysis of 53 reports of paraganglioma of the urinary bladder in Japan, only 3 cases (6%) had no hypertension, hematuria, or micturition attacks. 12 Unexpectedly, our patient had none of these symptoms and all the urine tests were within normal range. As paraganglioma is diagnosed incidentally, no preoperative study was carried out to determinine the blood or urinary levels of catecholamines.…”

Section: Discussionmentioning

confidence: 53%

“…In the reports only 40% of the cases were preoperatively diagnosed. 12 In evaluation of the cases with a query on paraganglioma, levels of blood and urinary catecholamines, and their metabolites, ultrasonography, computed tomography scan, and magnetic resonance imaging will be useful in differential diagnosis and in localizing the tumors.…”

Section: Discussionmentioning

confidence: 99%

“…In most of the reports, the tumor is found to be located mainly in the submucosa protruding into the lumen of the bladder and the surface is usually intact as we observed in the presented case, although it might show ulceration an rare occasions. 9,12,15 Paragangliomas of the bladder show histological features similar to adrenal pheochromocytomas: morphologically, in most cases there is a zellballen (cell clusters) pattern. Other variants are a solid growth pattern, a spindle or sarcomatoid pattern, a trabecular or ribbon pattern, and a strikingly predominant vascular pattern.…”

Section: Discussionmentioning

confidence: 99%

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Laparoscopic Resection of Urinary Bladder Paraganglioma

Dilbaz

Bayoglu

Oral

et al. 2006

Surgical Laparoscopy, Endoscopy &Amp; Percutaneous Techniques

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The case report of a 55-year-old woman with an incidentally diagnosed urinary paraganglioma of the bladder is presented. The patient had no irritative voiding symptoms, hematuria or hypertension. She was diagnosed to have an immobile solid mass on the left side neighboring the lower segment of the uterus. Transvaginal ultrasonography revealed a well-limited ovoid mass with solid and cystic areas adjacent to the urinary bladder and the uterus. Tumor markers were within normal range. Laparoscopy was performed for the treatment of the mass and complete excision of the cyst was accomplished. Frozen section was performed revealing a benign cystic structure but the identification of the origin was left to definitive histopathological examination which showed paraganglioma of the bladder. Immunohistochemically, the tumor cells were strongly positive for chromogranin A and synaptophysin and there was focal positiveness for neuron specific enolase although vimentin and cytokeratin were negative.

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Adrenal Medulla and Paraganglia

McNicol

2009

Endocrine Pathology:

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Paraganglioma of the Urinary Bladder: A Case Report and Review of the Japanese Literature

Cited by 14 publications

References 5 publications

Urinary Metabotyping of Bladder Cancer Using Two-Dimensional Gas Chromatography Time-of-Flight Mass Spectrometry

Urinary Metabotyping of Bladder Cancer Using Two-Dimensional Gas Chromatography Time-of-Flight Mass Spectrometry

Laparoscopic Resection of Urinary Bladder Paraganglioma

Adrenal Medulla and Paraganglia

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