Paragangliomas of the head and neck

Kupferman, Michael E.; Hanna, Ehab Y.

doi:10.1007/s11912-008-0024-9

Cited by 23 publications

(13 citation statements)

References 34 publications

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“…This frequency was compatible with previous reports (4)(5)(6)(7)21). It is well known that, as histopathological examination cannot distinguish a malignant tumor by morphological features in microscopic findings, malignancy or not is diagnosed by metastatic activity, namely clinical findings.…”

Section: Shamblin Classification ------------------------------------supporting

confidence: 92%

Multi-institutional survey of carotid body tumors in Japan

et al. 2018

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Abstract. There has been no attempt to clarify the status of patients with carotid body tumor (CBT) in Japan. This multi-institutional survey analyzed patients with CBT throughout Japan by gathering information on these patients from institutions that performed head and neck surgeries. Information from a total of 150 patients from 25 institutions from the past 20 years was employed in the present survey. There were 87 females and 63 males, and their mean age was 48.0 years old. The most common chief complaint was a neck mass and the mean suffering period was 46.1 months. Eighteen patients had a family history of paragangliomas and fifteen patients had bilateral CBTs. Among the 94 patients who underwent surgery to remove a CBT, 23 patients had tumors classified as Shamblin type I, 59 had type II and 12 had type III. The most frequent feeding artery of these CBTs was the ascending pharyngeal artery. Preoperative embolization of these arteries was effective in reducing blood loss; however, the operation time in Shamblin type I and II tumors was not improved. Thus these results revealed the status of patients with CBT and their treatment throughout Japan.

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Section: Shamblin Classification ------------------------------------supporting

confidence: 92%

Multi-institutional survey of carotid body tumors in Japan

et al. 2018

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“…Malignant PGs are defined by presence of pathologically confirmed PG cells in lymph nodes or in distant organs, rather than by the histological features of the primary tumor [2]. Only a small percentage of patients ultimately develop metastatic disease, and malignant PGs are believed to represent only 4% to 15% of all head and neck PGs [3-5]. When considering the major classes of PG sub-types, rates of malignancy are believed to be 2 - 4% for jugular-tympanic tumors, 6% for carotid body tumors, and 16 - 19% for vagal tumors [6,7].…”

Section: Introductionmentioning

confidence: 99%

Malignant head and neck paragangliomas: Is there an optimal treatment strategy?

et al. 2010

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BackgroundLittle is known about management and prognosis for malignant head & neck paragangliomas. We reviewed records of these patients to determine optimal treatment strategies.MethodsWe reviewed 113 cases of head & neck paragangliomas treated at our institution from 1970 to 2005. Nineteen patients were included in the study. All had primary surgical treatment at another institution. Metastatic disease was treated with radiation, chemotherapy, or both. Survival and complications were evaluated. P values were determined by Fischer's exact test.ResultsAll patients treated with chemotherapy and radiation age ≥ 40 years had disease progression. Of the patients < 40, two had stable disease; one had regression of disease with treatment. Patients without disease progression had better prognosis and were alive at last follow-up.ConclusionsClinical benefit was derived from aggressive treatment. However, careful consideration of the risks of observation versus intensive therapy should be undertaken when managing these patients.

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“…17 However, the incidence of metastasis is rare, representing only 4% to 15% of all head and neck tumors, 3,11,12 with only a 6% reported rate for carotid body tumors. 8 The majority of these metastases occur in regional lymph nodes (50%), with the remainder occurring in the liver and lungs.…”

Section: Discussionmentioning

confidence: 99%

“…Most PGs are benign, with only 4%-15% developing metastases, 11,12 usually isolated to regional lymph nodes. While surgery is commonly curative in benign PGs, the prognosis for malignant PGs remains poor, with 5-year mortality rates greater than 50%.…”

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confidence: 99%

Malignant carotid body tumor presenting with myelopathy: case report

Jeevan¹,

Saleh²,

LaBagnara³

et al. 2016

SPI

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Malignant carotid body tumors are rare, with spread of the tumor mostly noted in regional lymph nodes. Vertebral metastases are an exceedingly rare presentation, only reported in isolated case reports, and present a diagnostic and management challenge. A case of widespread vertebral metastasis, presenting with myelopathy, from a carotid body tumor is discussed in this paper, along with management strategies.

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Paragangliomas of the head and neck

Cited by 23 publications

References 34 publications

Multi-institutional survey of carotid body tumors in Japan

Multi-institutional survey of carotid body tumors in Japan

Malignant head and neck paragangliomas: Is there an optimal treatment strategy?

Malignant carotid body tumor presenting with myelopathy: case report

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