Paraileostomy Recontouring by Collagen Sealant Injection: A Novel Approach to One Aspect of Ileostomy Morbidity. Report of a Case

Smith, G.H.M.; Skipworth, Richard J E; Terrace, John D.; Helal, Basil; Stewart, Kenneth J.; Anderson, D. N.

doi:10.1007/s10350-007-9052-z

Cited by 6 publications

(5 citation statements)

References 15 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Permacol TM surgical implant is commercialized for soft tissue reconstruction and repair. It has been used in a variety of surgical fields since 1998 36,37 and it has been used successfully for the reconstruction of human soft tissue and as a supporting tissue in numerous gynecologic, urologic, and general surgical procedures involving the treatment of abdominal wall defects, 36,[38][39][40][41] hernia repair, [42][43][44] soft tissue reconstruction, 2,45 stress incontinence, and vaginal and rectal prolapse. 46 Nevertheless, the host response (human) is not frequently analyzed, most certainly for ethical reasons.…”

Section: Discussionmentioning

confidence: 99%

Effect of crosslinking on the performance of a collagen‐derived biomaterial as an implant for soft tissue repair: A rodent model

Brás

Proffitt²,

Bloor³

et al. 2010

J Biomed Mater Res

View full text Add to dashboard Cite

One of the main problems in healthcare is the loss of tissues resulting from diseases, post-surgery complications or trauma. As a result there is a need for biomaterials designed to promote tissue regeneration and improve wound healing. This study assessed the effect of crosslinking of a porcine dermal collagen matrix with regard to strength of implant/host tissue integration, implant biocompatibility and general healing in a rodent model. Permacol™, a crosslinked acellular collagenous biomaterial was compared with its noncrosslinked equivalent at 3, 6, and 12 months postsubcutaneous implantation. Both matrices were well tolerated and showed no evidence of inflammation or adverse responses either in the host tissue or implants. Progressive integration of the implants with the surrounding tissue was observed. Cellular response was similar for both collagenous matrices although, at 3 and 6 months, noncrosslinked implants showed a significantly higher level of cellular penetration than crosslinked implants. However, at 12 months crosslinked implants showed significantly higher levels of cellular density, neo-vascularisation and integration with host tissue. Additionally, at long term, noncrosslinked implants lost volume suggesting some absorption. The crosslinking process does not seem to be detrimental to cellular response and biocompatibility.

show abstract

Section: Discussionmentioning

confidence: 99%

Effect of crosslinking on the performance of a collagen‐derived biomaterial as an implant for soft tissue repair: A rodent model

Brás

Proffitt²,

Bloor³

et al. 2010

J Biomed Mater Res

View full text Add to dashboard Cite

show abstract

“…Individual case reports describing the use of injected porcine or bovine collagen treatments of peristomal skin contour defects have been described by Smith et al [ 8 ] and Arai et al [ 7 ]. To our knowledge, this report represents the largest single series of patients reported and the first report of the use of permanent fillers for the treatment of stoma leaks.…”

Section: Discussionmentioning

confidence: 99%

“…Smith et al [ 8 ] described a patient who developed leaking of his ileostomy due to an increase in body habitus leading to peristomal striae formation and irregularities of the skin surface. Resolution of the leaks was obtained after one injection of an unspecified amount of porcine collagen under general anesthetic.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Correction of Skin Contour Defects in Leaking Stomas by Filler Injection: A Novel Approach for a Difficult Clinical Problem

Weidmann

Al‐Niaimi

Lyon

2014

Dermatol Ther (Heidelb)

View full text Add to dashboard Cite

BackgroundStomal leaks can be associated with significant social, psychological and physical morbidity for ostomy patients. Poor fitting of the stoma appliance due to irregularities of skin contours is one cause of stoma leaks which commonly result in secondary irritant dermatitis prompting presentation to a dermatologist. In addition to skin-directed topical therapy and review of stoma appliances, correction of contour defects with intradermal injections of filler materials is one possible treatment to improve adhesion and reduce leaks.CasesWe report eight cases of ostomy patients, who presented with stoma leaks and associated dermatitis, who were treated with intradermal injections of the porcine collagen (Permacol™) or subcutaneous injections of polyacrylamide hydrogel (Aquamid Reconstruction™) for correction of skin contour defects. Resolution or improvement of symptoms was achieved for five patients, and no complications were noted as a result of treatment.ConclusionsThis report represents the largest series of ostomy patients treated for correction of peristomal skin contour defects with injection therapy. Treatment was well tolerated and performed in the outpatient setting under local anesthetic. Attempted correction of peristomal skin contour defects using injection of filler materials represents a potential alternative to surgical intervention and can result in significant benefits for the patient.Electronic supplementary materialThe online version of this article (doi:10.1007/s13555-014-0058-x) contains supplementary material, which is available to authorized users.

show abstract

“…However, these existing products show relatively weak adhesion strength with limited efficacy to prevent leakages from ostomy bags. Several strategies that utilize the injection of porcine or bovine collagen or synthetic hydrogels into the skin to create improved conformal adhesion of ostomy bags have been proposed (Arai & Okubo, 1999; Smith et al, 2007; Weidmann et al, 2014), but these methods still require complicated application procedures or surgery.…”

Section: Introductionmentioning

confidence: 99%

Biocompatible hydrogel ostomy adhesive

2020

View full text Add to dashboard Cite

With 700,000 affected annually (Grant et al., 2013), ostomies are life-saving redirective surgeries for those who have defective waste systems (e.g. urinary and digestive) caused by acute diverticulitis, colorectal cancer, trauma or inflammatory bowel disease (Burch, 2005; Dabirian et al., 2010). As a result of these surgical interventions, the stoma (i.e. an artificial opening) is created through the abdomen wall from the bladder, ileum or colon. To collect the stoma effluent, most use a one-piece closed ostomy bag that is often adhered around the stoma and disposed daily (Voergaard et al., 2007). Current ostomy bags have two main limitations that lead to leakage: (a) face plates that are ineffective interfaces due to their overly stiff composition and (b) weak adhesion resulting in short wear time and difficult application. While various commercially available adhesive pastes and glues have been introduced to reinforce adhesion of ostomy bag to abdominal skin, existing adhesives for ostomy bags still lack the ability to form strong and stable adhesion, often resulting in premature failures and leakages. Such leaked digestive effluent can damage surrounding skin tissues, creating painful swelling and

show abstract

Paraileostomy Recontouring by Collagen Sealant Injection: A Novel Approach to One Aspect of Ileostomy Morbidity. Report of a Case

Cited by 6 publications

References 15 publications

Effect of crosslinking on the performance of a collagen‐derived biomaterial as an implant for soft tissue repair: A rodent model

Effect of crosslinking on the performance of a collagen‐derived biomaterial as an implant for soft tissue repair: A rodent model

Correction of Skin Contour Defects in Leaking Stomas by Filler Injection: A Novel Approach for a Difficult Clinical Problem

Biocompatible hydrogel ostomy adhesive

Contact Info

Product

Resources

About